DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and ecel1

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_012818808.2	Gene:	ecel1 / 100496473	XenbaseID:	XB-GENE-989944	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	766	Identity:	189/766 - (24%)
Similarity:	296/766 - (38%)	Gaps:	189/766 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LVVILGVML-LK-LAAAQD------CQQQ---------LDNDTDAEVKPCENFHQYACGNW---- 54
            |.||||.|| || |:..||      ||::         :.|:.|..:.||.:|:.:|||.|
Frog    67 LCVILGCMLVLKYLSMEQDVQCLEGCQERKAFMRASKFITNNIDPTISPCTDFYSFACGGWLRRH 131

  Fly    55 --------YSNTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYR 111
                    |..    |....:...:.:.:|.||.:|...:.|             :..::...::
Frog   132 GIPEDKLIYGT----IAAIGEQNEEKLEHLLLQPVRRKHKGS-------------AERKVKEFFK 179

  Fly   112 CCLLSGQSIRTYTDALSRSGANFPLLANHTGGSFD--------WVLANAALRTYGAQG---LWRL 165
            .||    ::|.    :.|.||...|......|.:|        |.......:|.|...   .:.:
Frog   180 SCL----NMRD----IDRLGARPMLQVIEDCGGWDLPEDPRTQWDFNELLYKTQGVYSTAVFFSM 236

  Fly   166 LVKDNWQSADQRIFYM------LPPKFDLLGRDDELNEFL--YQRYLKILLLELGLRVRRAALLA 222
            .|..:.:::.:.|..:      ||.:...||:|:|..:.|  |:.:::.:|..||  |......|
Frog   237 TVSLDDKNSSRYIIRIDQDGLTLPERTLYLGQDEESIKVLEAYKVFMQTILSLLG--VENVQKKA 299

  Fly   223 EKLVAFEKSLQKLLPNDAEQTLVLRKPQS-------LKDLESQLPRLE----LKRYFETILEGID 276
            |:::..|:.|..:..::.:.   :|:..|       |..|:...|.|.    |.|.|.|   ...
Frog   300 EEILHLEQHLSNITISEFDD---MRRDISTMYNKVTLAQLQQITPHLNWKNLLNRIFHT---NFP 358

  Fly   277 WDSKTLLLVADLDYLQGLQRL--------------------LAEHTSDPMVLSTWLLLQLPAYFE 321
            .|.:.::|..  ||:|.:..:                    |:||.|.|.         ..|..|
Frog   359 EDEEVVVLAT--DYMQKVSEMIRSTPASVLHNYMLWRIVVVLSEHLSTPF---------RDAIHE 412

  Fly   322 L--RLHDDDKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLFRDLKQQF 384
            |  .:...:|.......||.|..|.....||.|.::    |.:.......:||   |..::|...
Frog   413 LSKEMEGSEKQAELTKVCLTQANKHFGMALGALFVE----EYFSSSSKAKVQQ---LVENIKHIL 470

  Fly   385 ELVLNETEVFNEDLVTRNLARDKLRAMR--------LLTPRLQD-----PINGGPGTPQLGGNCD 436
            :..|.|.:..  |..|:..||:||:.|.        ||.|...|     .:|.......:
Frog   471 DYRLEELDWM--DTETKQAAREKLKHMMVMIGYPDVLLQPESMDKEYEFEVNEKTYFKNI----- 528

  Fly   437 ANLLQLSLSQAKLEYRQVFGEPVTSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEAD 501
            .|.::.|:..|....||...:....:|  |.::||||....|::..|.|::...|.      :.|
Frog   529 LNSIRYSIKMAVRRIRQEVDKSAWLLP--PQALNAYYLPNKNQMVFPAGILQPTLY------DPD 585

  Fly   502 TRAKLS-AGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYLGVRYSNATL 565
            ....|: .|:|.|:.||:.|.:|..|..|||.|.... .|:..:..:|..:|.|.:.: |.|.|:
Frog   586 FPQSLNYGGIGTIIGHELTHGYDDWGGQYDANGNPIQ-WWTEDSYSKFLKKAECIVDL-YENFTV 648

  Fly   566 ---------TVNENIADTEGLRLALDTYRH------------RSGATNLRTFFVAFAQNWCGTVA 609
                     |:.|||||..||:||...|:.            |...|:.:.||:|||||||....
Frog   649 YNQRVNGRTTLGENIADLGGLKLAYYAYQKWVRDNGPERPLPRLKYTHDQLFFIAFAQNWCIKRR 713

  Fly   610 STSGLSQ-----HAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            |.|...|     ||....||...|....|||..|.|...|.||||:||.:|
Frog   714 SQSIYLQVLTDKHAPEHYRVMGSVSQFEEFGRVFHCPRNSPMNPVHKCSVW 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	173/723 (24%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	171/716 (24%)
ecel1	XP_012818808.2	M13	113..762	CDD:341056	171/716 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020