DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and phex

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_004911718.1	Gene:	phex / 100496470	XenbaseID:	XB-GENE-1012247	Length:	750	Species:	Xenopus tropicalis

Alignment Length:	743	Identity:	161/743 - (21%)
Similarity:	285/743 - (38%)	Gaps:	162/743 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LAAAQDCQQQLDNDTDAEVKPCENFHQYACGNWYSNTSQRILGAHDMRS----KWV-ANLKLQLI 81
            :.||...:.:::...|    ||::|.|||||.|......    ..||.:    .|: .|:.|:|.
Frog    61 IEAAASIRSKMNLSVD----PCDDFFQYACGGWIEENPI----PDDMSNYGIYPWLRTNVDLKLK 117

  Fly    82 RYLEE--SSSTDSFSANTSVTTSTAQLGTLYRCCL----LSGQSIRTYTDALSRSGANFPLLANH 140
            ..||:  |...||        .:..::.|.|..|:    :....|:.....|.:....:|:|.::
Frog   118 ALLEKPISKRRDS--------EAIQKVKTFYISCMNETQIEEDDIKPILKILKQPSLRWPVLESN 174

  Fly   141 TGGSFDW------VLANAA--LRTYGAQGLWRLLVKDNWQSADQRIFYMLPPKFDLLGRDDEL-N 196
            .|....|      .|...|  .|.|......|:.|..:.:.::..|..:......||..:|.| |
Frog   175 IGSDGKWSERKFSFLQTVADLRRLYSTSVFLRVYVAIDDKVSNNFILKLDQASLSLLSHEDYLDN 239

  Fly   197 EFLYQRYLKILL-------LELGLRVRRAALLAEKLVAFEKSLQKL-LPNDAEQTLVLRKPQSLK 253
            ..:.::|...||       :.||....||....:.|:..|..|.:: :|.:...:.::....::.
Frog   240 STIAKKYRDALLEFMVDVAVLLGANKTRAETDMKALIELETKLAQITVPQENRTSEMMYNKMNIS 304

  Fly   254 DLESQLPRLELKRYFETI--------LEGIDWDSKTLLLVADLDYLQGLQRLLAEHTSDPMVLST 310
            :|.:.:|:.:...|.:.|        |:.||.....::.|.  .:.:.|..::  .:.:...|:.
Frog   305 ELSAMIPQFDWLSYLKNIIDFNIYPELKNIDLSENVIVRVP--QHFKDLFNII--ESEEKRTLAN 365

  Fly   311 WLLLQLPAY---------FELR-------LHDDDKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLG 359
            :|:.:| .|         |:.|       |...:.|..:.:.|:..:...:|..:|:|.:.....
Frog   366 YLIWRL-VYSRIPNLSRRFQYRQLEFARILLGTNSLAGRWDRCVNYVENSIPYPVGKLFVDAHFQ 429

  Fly   360 ESYQDVYDTAIQQIAVLFRD-LKQQFELVLNETEVFNEDLVTRNLARDKLRAMRLLTPRLQDPIN 423
            |..:|:.:..:..|...|.| |:::.:.:..||::           :.|.:|:.::..
Frog   430 EDKKDMMEELVDGIRWAFIDMLEKENDWMDAETKI-----------KAKQKAVTVMAK------- 476

  Fly   424 GGPGTPQLGGNCDANLLQLSLSQAKLEYRQVFGEPV---------------TSVP-----ADPLS 468
              .|.|:...|  ...|...:...|......||..:               .:||     .:|.:
Frog   477 --VGYPEFLFN--DTYLNEDIKMLKFSESDYFGNVLQTLHFISQSDFYWLRRNVPKKEWFTNPTT 537

  Fly   469 VNAYYRLKLNRIELPLGLMATPL---IQQQCSKEADTRAKLSAG-LGYILAHEMVHAFDLDGLNY 529
            |||:|....|:|..|.|.:..|.   :|...|        ||.| :|.|:.||..|.||.:|..|
Frog   538 VNAFYSASTNQIRFPAGELQKPFFWGVQYPRS--------LSYGAIGVIVGHEFTHGFDNNGRKY 594

  Fly   530 DATGQLANGQWSARAIIRFGLRAGCYLGVRYSN-----------ATLTVNENIADTEGLRLALDT 583
            |..|.|.: .|::.:..||..:..|.: .:|:|           ...|::|||||..|:|.:...
Frog   595 DKEGNLFS-WWTSESEERFKNKTLCMV-EQYNNYYWKQAGLHVKGMKTLSENIADNGGIRESFRA 657

  Fly   584 YRH-----RSG----------ATNLRTFFVAFAQNWCGTVASTSGLSQ-----HAGHAERVNNVV 628
            ||.     |.|          ..|.:.||:::|...|.:....|...|     |:....||...:
Frog   658 YRKWIEDLRKGKEEMLLPGLDLNNNQLFFISYAHVRCNSFRIESARDQIMNGVHSPPQFRVIGAM 722

  Fly   629 GNMPEFGDTFECKATSQMN-PVNKCHIW 655
            .|..||...|.|...|:|| ..|.|.:|
Frog   723 SNFEEFHKAFSCPKDSKMNRGANSCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	158/728 (22%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	156/721 (22%)
phex	XP_004911718.1	M13	75..741	CDD:341056	154/718 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010