DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and ece1

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_031762312.1	Gene:	ece1 / 100485607	XenbaseID:	XB-GENE-1014218	Length:	782	Species:	Xenopus tropicalis

Alignment Length:	776	Identity:	176/776 - (22%)
Similarity:	301/776 - (38%)	Gaps:	209/776 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LVVILGVMLL--------------KLAAAQDC-------QQQLDNDTDAEVKPCENFHQYACGNW 54
            |||:|.:.|.              ::..::.|       .:.||...|    ||::|:||:||.|
Frog    85 LVVLLSLGLFMCLLALSLQYRNSHRVCLSESCISVTSSILRSLDRSAD----PCQDFYQYSCGGW 145

  Fly    55 YSNTSQRILGAHDMRSKWVANLKL-----QLIRYLEESSSTDSFSANTSVTTSTAQ--LGTLYRC 112
            .....     ..|..|:|....:|     ..:::|.|:|:.:        |.|||:  ....::.
Frog   146 IKGNP-----VPDGHSRWGTFNELWEHNQATMKHLLENSTIE--------TNSTAERKAQRYFQA 197

  Fly   113 CLLSGQSIRTYTDALSRSGANFPL--LANHTGGSFDWVLANAALRTYGAQGLWRLLVKDNWQSAD 175
            |:...:        :...||. ||  |....||   |.:.          |.|.   :||:|...
Frog   198 CMNETK--------IEELGAK-PLQDLIQKLGG---WAIT----------GPWD---RDNFQETL 237

  Fly   176 QRI--FYMLPPKFDLLGRDDELN------------------EFLYQRYL------KILLLELGLR 214
            |.:  .|...|.|.:....|..|                  ||    ||      |:|...|...
Frog   238 QLVTAHYRTSPFFSVFVSADSKNSNSNVIQIDQSGLGLPSREF----YLNKTENEKVLTGYLNFM 298

  Fly   215 VRRAALLA----------EKLVAFEKSLQKL-LP----NDAEQTLVLRKPQSLKDLESQLPRLEL 264
            ::...||.          ::::.||.:|..: :|    .|.||.........||||   :|.::.
Frog   299 IQLGVLLGGAENSTREQMQEILDFETTLANITIPQEKRRDEEQIYHKMAAGELKDL---VPAVDW 360

  Fly   265 KRYFETILEGIDWDSKTLLLVADLDYLQGLQRLLAEHTSDPMVLSTWLLLQL----PAYFELRLH 325
            ..:.:|:...:..:....::|...:||..:..|:  :::|..:|:.:::..|    .::.:.|..
Frog   361 MPFLQTVFYPVAINESEPVVVYAKEYLVAVSGLI--NSTDKRILNNYMMWNLVRKASSFLDQRFQ 423

  Fly   326 D-DDKL-----GNQR------NHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLFR 378
            | ::||     |.::      ..|:......:...||.:.::....|      ::.:|.:.:: :
Frog   424 DAEEKLMEVMYGTKKTCLPRWKFCISDTDNNLGFALGAMFVKATFAE------NSKLQALKMI-K 481

  Fly   379 DLKQQFELVLNETEVFNEDLVTRNLARDKLRAMR--------LLTPRLQDPINGGPGTPQLGGNC 435
            ::|..||..|:.....:::  ||..||:|..|:.        ::.|:..|.:..
Frog   482 EIKAAFEENLSTLTWMDDE--TRRAAREKAEAIYDMIGYPNFIMDPKELDKVFN----------- 533

  Fly   436 DANLLQLSLSQAKLEY----RQVFGEPVTSVPA------DPLSVNAYYRLKLNRIELPLGLMATP 490
            |.|:......:..:.:    .:|..:.:...|:      .|.:|||||....|.|..|.|::..|
Frog   534 DYNVTSDFYFENGMRFYNFSARVTADQLRKAPSKDQWSMTPPTVNAYYSPTKNEIVFPAGILQAP 598

  Fly   491 LIQQQCSKEADTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCY 555
            ..     ..:...|....|:|.::.||:.||||..|..||..|.| ...|...::..|..:..|
Frog   599 FY-----TSSSPTALNFGGIGVVMGHELTHAFDDQGREYDKDGNL-RPWWKNASVEAFKKQTEC- 656

  Fly   556 LGVRYSNATL---------TVNENIADTEGLRLALDTYRH---RSGA---------TNLRTFFVA 599
            :..:|.|.|:         |:.|||||..||:.|...|::   ::||         :|.:.|||.
Frog   657 ITEQYGNYTVNGEPVNGRQTLGENIADNGGLKAAYRAYKNWVRKNGAEQLLPSLGLSNDQLFFVG 721

  Fly   600 FAQNWCGTVASTS---GL--SQHAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            |||.||....|.|   ||  ..|:....||...|.|..||.:.|.|...|.|||.|||.:|
Frog   722 FAQVWCSVRTSESSHEGLITDPHSPSRFRVIGSVSNSQEFAEHFRCPPGSPMNPRNKCEVW 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	167/729 (23%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	165/722 (23%)
ece1	XP_031762312.1	M13	131..780	CDD:341056	166/726 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010