DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and PDE5A

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	NP_001074.2	Gene:	PDE5A / 8654	HGNCID:	8784	Length:	875	Species:	Homo sapiens

Alignment Length:	999	Identity:	202/999 - (20%)
Similarity:	347/999 - (34%)	Gaps:	258/999 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 LQRSSNNLQQQQQQQQQQQQHLQLQLQQADERLLRKIGYIASRVRCLSKYYGDFRLVNPYSARRQ 211
            ::|:..:..||:||||.|||..|.:.|.:.|..|..              :.||..  .|..|:.
Human     1 MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDD--------------HWDFTF--SYFVRKA 49

  Fly   212 RRQLQEILLRHSIFDPGKEHQRAIVLAAATAAIAGPLAAIDCVCGSS---SISLEAVSSRSRSSE 273
            .|::......          :|...:......|.|...:..|....|   ..|.....:|..|:.
Human    50 TREMVNAWFA----------ERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISAS 104

  Fly   274 LEDDHHEQDQVQEEQEQEQHQGDT---EDNEEEQEHPSEKPERTDIEEEPPPAIAVTTTTTATVR 335
             |.|...:..|.::.|     |..   .|:|::::.|. .|.|.|.:|        ....:..:.
Human   105 -EFDRPLRPIVVKDSE-----GTVSFLSDSEKKEQMPL-TPPRFDHDE--------GDQCSRLLE 154

  Fly   336 RKSSSSSTISGTAT-------VSGSVSVSASASQSFCSNNINLLEELLIQFYEEQDHRSNLTVIR 393
            .....||.:..||.       :.|.:|....:....|.::.|  ::.||....:....|.|..:
Human   155 LVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSN--DKFLISRLFDVAEGSTLEEV- 216

  Fly   394 HHHHQQHQQHQQQQRITNNNNNNNNCNSIQNNNNMSNPAATAAATATPSVEQPATSGTTNIHLQP 458
                                  :|||..::.|..:....|...                    :|
Human   217 ----------------------SNNCIRLEWNKGIVGHVAALG--------------------EP 239

  Fly   459 TSLPDGSDNPRRRRASDCSAVQAALQNQLHCITLKNNN---CGKAMPFHRGS------------- 507
            .::.|..::||..  ::...:.......:.|:.:||:.   .|.|...::.|
Human   240 LNIKDAYEDPRFN--AEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKD 302

  Fly   508 -------CGAA--GEHLLAANSIANRATIILSKSCSNVDGDATA-------TAATALSSTVGGGI 556
                   ||..  ...|...:.:.|:...:|....|.:..:..:       .|||.:|
Human   303 FAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS------- 360

  Fly   557 GGIGGSIKMR---------------ASATDIETNALNGARDAIVASNNGNNGN------------ 594
                 .::::               :|...:|...|..:.|.:...::.|..|
Human   361 -----FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME 420

  Fly   595 ----------------NGNNGN-NEYSILQL----------NNTIIQCHFND--DDFRALVKDLK 630
                            ..|.|| |:..|..|          |..|..|...:  ::....||...
Human   421 PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFN 485

  Fly   631 RKVE-YTERMNWLCLSKRPLGPPHRKSSLPKHQEVKRRF------LEICD---TTFSEEVR---- 681
            |..| :.|.....|    .||..:.:    .::.|:|..      ||:..   :...||.|
Human   486 RNDEQFLEAFVIFC----GLGIQNTQ----MYEAVERAMAKQMVTLEVLSYHASAAEEETRELQS 542

  Fly   682 -AALRLP----------AFDSYEWSDADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYN 735
             ||..:|          :|..:|.||.:.......||.:|..::.|.:..:.|..|:..|.|:|.
Human   543 LAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYR 607

  Fly   736 E-VPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTEL 799
            : |.:||:||.|..||.|:|..:...:.::|.|||.|.||::.:.|||||.|.||.|...:...|
Human   608 KNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPL 672

  Fly   800 ALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFM 864
            |..|.. |.:|:||......:|..|...|....|.:.:....:.|.:.|||||:|.:.:...:|.
Human   673 AQLYCH-SIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFF 736

  Fly   865 EI--TPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSE-GLPV 926
            |:  ...|:..:.....|...:|:...|:|...:|..:.:...:.:..|||.|...|:.| .:..
Human   737 ELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEP 801

  Fly   927 TPFMDPDKVSK-PGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEYYRRLNDAQTKTR- 989
            |..|:.:|.:| |..||.||..:.|.|:|||..:..:...|:               |...|.|
Human   802 TDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLL---------------DGCRKNRQ 851

  Fly   990 --KSVADSNTSATSDSNSGTIDSN 1011
              :::|:.......:..||....|
Human   852 KWQALAEQQEKMLINGESGQAKRN 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	71/231 (31%)
PDE5A	NP_001074.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		12/27 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..102		4/23 (17%)
		GAF	164..321	CDD:214500	28/203 (14%)
		GAF	347..513	CDD:214500	27/185 (15%)
		PDEase_I	612..847	CDD:278654	73/250 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820