DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and PDE8B

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	NP_001336678.1	Gene:	PDE8B / 8622	HGNCID:	8794	Length:	906	Species:	Homo sapiens

Alignment Length:	1104	Identity:	219/1104 - (19%)
Similarity:	372/1104 - (33%)	Gaps:	326/1104 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QDSGCSSSSSRRGSSSAAAATSTAATAAETAAAAAATTTSSSDEETLETLTIITTTITDSDIHAT 67
            :||..|||..:..|.|...|........:|.||.|...:.:|...:               :...
Human    18 RDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASGPPS---------------VARV 67

  Fly    68 TTTTTVIASGTATTAAAAATTATLATLATLASNSDIEDSSPVESEDSEECEYIEIDCQTTAQEGT 132
            ....|.:.||::..:||.|.|.:........|:::.|..:                |.|:.:.|.
Human    68 RRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQT----------------CYTSVKIGA 116

  Fly   133 SPSGGSSSSGNAVLLQRSSNNLQQQQQQQQQQQQHLQLQLQQADERLLR---------------- 181
            |               ::|:||:.::......||....:::....||.:
Human   117 S---------------QTSSNLRVKKVDAYLHQQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQS 166

  Fly   182 --------KIGY---IA----SRVRC-LSKYYG----DFRLVNPYSARRQRRQL------QEILL 220
                    :.||   ||    |.:.| |.|::.    |.|....:.|....|.:      :..::
Human   167 DGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRATNPSEHTVI 231

  Fly   221 RHSIFDPGKEHQRAIVLAAATAAIAGPLAAIDCV--CGSSSISLEAVSSRSR------------- 270
            ...:.....:|:.|.||....|...........:  |.:..|.:|....||:
Human   232 LAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTAL 296

  Fly   271 -----SSELEDDHHEQDQVQE--EQEQEQHQGDTEDNEEEQEHPSEKPERTDIEEEPPPAIAVTT 328
                 :.|:..|.|....|..  |:....|:|:.. .:|..:.|.....|.|:         :.|
Human   297 DHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELL-GKELADLPKSDKNRADL---------LDT 351

  Fly   329 TTTAT-----------VRRKSSSS----STISGTATVSGSVSVSASASQSFCSNNINLLEELLIQ 378
            ..|..           .||||..|    ..|:......|.:....|..:..|:.:.|.      |
Human   352 INTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNK------Q 410

  Fly   379 FYEEQDHRSNLTVIRHHHHQQHQQHQQQQRITNNNNNNNNCNSIQNNNNMSNPAATAAATATPSV 443
            .::......:.:....|..:...:.::...:.:.::..::..|:||....|     .|...:.::
Human   411 IHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPS-----MARIHSMTI 470

  Fly   444 EQPATSGTTNIHLQPTSLPDGSDNPRRRRASDCSAVQAALQNQLHCITLKNNNCGKAMPFHRGSC 508
            |.|.|.....|:....:.|              ..|..||...|..:
Human   471 EAPITKVINIINAAQENSP--------------VTVAEALDRVLEIL------------------ 503

  Fly   509 GAAGEHLLAANSIANRATIILSKSCSNVDGDATATAATALSSTVGGGIGGIGGSIKMRASATDIE 573
                           |.|.:.|......|.|...      |..|||                 :.
Human   504 ---------------RTTELYSPQLGTKDEDPHT------SDLVGG-----------------LM 530

  Fly   574 TNALNGARDAIVASNNGNNGNNGNNGNNEYSILQLNNTIIQCHFNDDDFRALVKDLKRKVEYTER 638
            |:.|...        :||......|.:..:|.|.:..||       :|....:..|....|
Human   531 TDGLRRL--------SGNEYVFTKNVHQSHSHLAMPITI-------NDVPPCISQLLDNEE---- 576

  Fly   639 MNW--------LCLSKRPLGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRAALRLPAFDSYEWS 695
             :|        ....||||
Human   577 -SWDFNIFELEAITHKRPL---------------------------------------------- 594

  Fly   696 DADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEV-PFHNFRHCFCVAQMMYAITRQA 759
                ::|...:|...|..|..:....|||.|...:..:|:.. .:||..|...|.........:.
Human   595 ----VYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKE 655

  Fly   760 NLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRL-LEH 823
            .:...|..|:.:..|::...||:||||..|.:..||.:|||:.|||.:.||:||.::||:| ::.
Human   656 RVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKD 720

  Fly   824 PECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFM---------EITPIFDYSNRAHIN 879
            .:||||||..|:.:..:|:.||..:|||:|.:|.|.:.:|:         ||.......|.|..|
Human   721 TKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKN 785

  Fly   880 ------LLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVT-PFMDPDKVSK 937
                  |:..::||.||::|..||:|:...|..|:.:|:|||:..||.:||||. |..|.:..|.
Human   786 FPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSI 850

  Fly   938 PGSQVRFIGLVLLPLFEA------LGELVPELTELIIIPVRIALEYYRRLNDAQTKTRKSVADS 995
            |.||:.||...:..:|:|      |..|:..|.:        ..::::.|:|.:.|:.:..:||
Human   851 PKSQISFIDYFITDMFDAWDAFAHLPALMQHLAD--------NYKHWKTLDDLKCKSLRLPSDS 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	85/250 (34%)
PDE8B	NP_001336678.1	PDE8	1..47	CDD:285793	8/28 (29%)
		PAS_9	301..398	CDD:315989	20/106 (19%)
		PDEase_I	635..882	CDD:306695	84/246 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950