Protein Alignment Pde9 and PDE2

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_015005.1
• Gene: PDE2 / 854542
• SGDID: S000005887
• Length: 526
• Species: Saccharomyces cerevisiae
• Alignment Length: 439
• Identity: 114/439 - (25%)
• Similarity: 173/439 - (39%)
• Gaps: 100/439 - (22%)

  Fly   592 NGNNGN-----NGN---------NEYSILQLNNTIIQCHFNDDDFRALVK-DLKRKVEYTERMNW 641
            :|.|.|     |||         |.|::|        .|.||...:.|.| .:.|.:...|.|::
Yeast   133 DGINKNSYGTVNGNSVPTQACEANIYTLL--------LHLNDSKAQHLRKASVPRLIRNIEFMSF 189

  Fly   642 LCLSKRPLGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRAALRLPAFDSYEWSDADVIHLMQTM 706
            |            ...:.|..:....:..|..|.            .|.:...|..::|....|:
Yeast   190 L------------SDPIEKISQEGSHYWNILSTW------------DFCALSLSTQELIWCGFTL 230

  Fly   707 FVELGFIEKFSIPVDTLREWLYEVYKHYNEV-PFHNFRHCFCVAQMMYAITRQANLLSRLGDLEC 770
            ..:|....|..|..:.|...|:.:...|::| .||||||..   .:|.|..|....|.:...::.
Yeast   231 IKKLSKDAKVLIADNKLLLLLFTLESSYHQVNKFHNFRHAI---DVMQATWRLCTYLLKDNPVQT 292

  Fly   771 LILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLL-EH-PECNIFKNFS 833
            |:|.::.|.||:.|||.||....|..:|:|..:.::|.|||.|..:..:|| || |:   ..:.|
Yeast   293 LLLCMAAIGHDVGHPGTNNQLLCNCESEVAQNFKNVSILENFHRELFQQLLSEHWPQ---LLSIS 354

  Fly   834 RDTFNNIREGIIRCILATDMARHNEILTQFMEITPIFDYSNRAHINLLCMILIKVADISNEARPM 898
            :..|:.|.|    .|||||||.|::...:.|...|:      ..|.|:.:| ||.|||||..|.:
Yeast   355 KKKFDFISE----AILATDMALHSQYEDRLMHENPM------KQITLISLI-IKAADISNVTRTL 408

  Fly   899 DVAEPWL--------DRLLQEFF-----------------AQSAAEKSEGLP--VTPFMDPDKVS 936
            .::..|.        |..|.|.|                 ..|..|..|.:.  :....|||.:.
Yeast   409 SISARWAYLITLEFNDCALLETFHKAHRPEQDCFGDSYKNVDSPKEDLESIQNILVNVTDPDDII 473

  Fly   937 K-----PGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEYYRR 980
            |     |..|:.||.......|.||.:....| :.:...|:|..||:.:
Yeast   474 KDHPHIPNGQIFFINTFAEVFFNALSQKFSGL-KFLSDNVKINKEYWMK 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	78/261 (30%)
PDE2	NP_015005.1	PDEase_I	264..513	CDD:395177	78/266 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I1950
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46491
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930