Protein Alignment Pde9 and PDE2

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_015005.1
• Gene: PDE2 / 854542
• SGDID: S000005887
• Length: 526
• Species: Saccharomyces cerevisiae
• Alignment Length: 439
• Identity: 114/439 - (25%)
• Similarity: 173/439 - (39%)
• Gaps: 100/439 - (22%)

  Fly   592 NGNNGN-----NGN---------NEYSILQLNNTIIQCHFNDDDFRALVK-DLKRKVEYTERMNW 641
            :|.|.|     |||         |.|::|        .|.||...:.|.| .:.|.:...|.|::
Yeast   133 DGINKNSYGTVNGNSVPTQACEANIYTLL--------LHLNDSKAQHLRKASVPRLIRNIEFMSF 189

  Fly   642 LCLSKRPLGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRAALRLPAFDSYEWSDADVIHLMQTM 706
            |            ...:.|..:....:..|..|.            .|.:...|..::|....|:
Yeast   190 L------------SDPIEKISQEGSHYWNILSTW------------DFCALSLSTQELIWCGFTL 230

  Fly   707 FVELGFIEKFSIPVDTLREWLYEVYKHYNEV-PFHNFRHCFCVAQMMYAITRQANLLSRLGDLEC 770
            ..:|....|..|..:.|...|:.:...|::| .||||||..   .:|.|..|....|.:...::.
Yeast   231 IKKLSKDAKVLIADNKLLLLLFTLESSYHQVNKFHNFRHAI---DVMQATWRLCTYLLKDNPVQT 292

  Fly   771 LILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLL-EH-PECNIFKNFS 833
            |:|.::.|.||:.|||.||....|..:|:|..:.::|.|||.|..:..:|| || |:   ..:.|
Yeast   293 LLLCMAAIGHDVGHPGTNNQLLCNCESEVAQNFKNVSILENFHRELFQQLLSEHWPQ---LLSIS 354

  Fly   834 RDTFNNIREGIIRCILATDMARHNEILTQFMEITPIFDYSNRAHINLLCMILIKVADISNEARPM 898
            :..|:.|.|    .|||||||.|::...:.|...|:      ..|.|:.:| ||.|||||..|.:
Yeast   355 KKKFDFISE----AILATDMALHSQYEDRLMHENPM------KQITLISLI-IKAADISNVTRTL 408

  Fly   899 DVAEPWL--------DRLLQEFF-----------------AQSAAEKSEGLP--VTPFMDPDKVS 936
            .::..|.        |..|.|.|                 ..|..|..|.:.  :....|||.:.
Yeast   409 SISARWAYLITLEFNDCALLETFHKAHRPEQDCFGDSYKNVDSPKEDLESIQNILVNVTDPDDII 473

  Fly   937 K-----PGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEYYRR 980
            |     |..|:.||.......|.||.:....| :.:...|:|..||:.:
Yeast   474 KDHPHIPNGQIFFINTFAEVFFNALSQKFSGL-KFLSDNVKINKEYWMK 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	78/261 (30%)
PDE2	NP_015005.1	PDEase_I	264..512	CDD:459723	78/265 (29%)