Protein Alignment Pde9 and Pde2a

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_001137319.1
• Gene: Pde2a / 81743
• RGDID: 620965
• Length: 935
• Species: Rattus norvegicus
• Alignment Length: 898
• Identity: 188/898 - (20%)
• Similarity: 323/898 - (35%)
• Gaps: 251/898 - (27%)

  Fly   144 AVLLQRSSNNLQQQQQQQQQQQQHLQLQLQQADERLLRKIGYIASRVRCLSKYYGDFRLVNPYSA 208
            ||:|.........::|..|..::|..:.||               ||:.|
  Rat   158 AVILVHCGQLSDSEEQSLQVVEKHALVALQ---------------RVQAL--------------- 192

  Fly   209 RRQRRQLQEILLRHSIFDPGKE---------HQRAIVLAAATAAIAGPLAAIDCVCGSSSISLEA 264
              |:|:.:.:  :::..||.::         |.|.|:      .:.|.|..:|    ::|:.|:.
  Rat   193 --QQRRPEAV--QNTSADPSEDQKDEKGYTAHDRKIL------QLCGELYDLD----ATSLQLKV 243

  Fly   265 VSSRSRSSELEDDHHEQDQVQEEQEQ-------EQHQGDTEDNEEEQEHPSEKPERTDIEEEPPP 322
            :  |....|.:..|.....|.|:..|       |:..|      ||...|........:.|:
  Rat   244 L--RYLQQETQATHCCLLLVSEDNLQLSCKVIGEKVLG------EEVSFPLTMGRLGQVVED--- 297

  Fly   323 AIAVTTTTTATVRRKSSSSSTISGTATVSG-------SVSVSASASQSF----CSNNINLLEELL 376
                    ...::.|..:|..:.....:.|       .|.|.:.|:...    |:.|     :|.
  Rat   298 --------KQCIQLKDLTSDDVQQLQNMLGCELRAMLCVPVISRATDQVVALACAFN-----KLG 349

  Fly   377 IQFYEEQDHRSNLTVIRHHHHQ---------QHQQHQQ--------------------------Q 406
            ..|:.::|.|:    |:|..|.         ..|:.|:                          |
  Rat   350 GDFFTDEDERA----IQHCFHYTGTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQ 410

  Fly   407 QRITNNNNNNNN--CN-SIQNNNNMSNPAATAAATATPSVE--QPATSGTTNIHLQPT----SLP 462
            :.||...|.:|.  |: .:.:.|.:.............|.|  .||..|... |:..|    ::|
  Rat   411 EIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAG-HVATTGQILNIP 474

  Fly   463 DGSDNPRRRRASDCSAVQAALQNQLHCITLKNNNCGKAMPFHRGSCGAAGEHLLAANSIANRATI 527
            |...:|...|..|.|.  ......:.|..:||.|                :.::....:.|:
  Rat   475 DAYAHPLFYRGVDDST--GFRTRNILCFPIKNEN----------------QEVIGVAELVNK--- 518

  Fly   528 ILSKSCSNVDGDATATAATALSSTVGGGIGGIGGSIKMRASATDIETNALNGARDAIVASNNGNN 592
            |.....|..|.|    .|||.|...|..|            |..:....:|.|
  Rat   519 INGPWFSKFDED----LATAFSIYCGISI------------AHSLLYKKVNEA------------ 555

  Fly   593 GNNGNNGNNEYSILQLNNTIIQCHF--NDDDFRALVKDLKRKVEYTERMNWLCLSKRPLGPPHRK 655
                     :|. ..|.|.::..|.  :||::..|:.|                ..:|:.
  Rat   556 ---------QYR-SHLANEMMMYHMKVSDDEYTKLLHD----------------GIQPVA----- 589

  Fly   656 SSLPKHQEVKRRFLEICDTTFSEEVRAALRLPAFDSYEWSDADVIHLMQTMFVELGFIEKFSIPV 720
                           ..|:.|:........||        :.|....:.:|..::.||..:.|..
  Rat   590 ---------------AIDSNFANFTYTPRSLP--------EDDTSMAILSMLQDMNFINNYKIDC 631

  Fly   721 DTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHP 785
            .||..:...|.|.|.:.|:||:.|.|.|:...|.:.:...|.:.|.|:|...|.:||:||||||.
  Rat   632 PTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELSNYLEDIEIFALFISCMCHDLDHR 696

  Fly   786 GYNNIYQINARTELALRY-NDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCIL 849
            |.||.:|:.:::.||..| ::.|.:|.||.:.|..:|....||||.:|||..:..:.:.:...||
  Rat   697 GTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIIL 761

  Fly   850 ATDMARHNEILTQFMEITPI-FDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFF 913
            |||:|.|..|.....::..: :|.:|:.|..||..:|:...|:|::.:.........:.:.:|||
  Rat   762 ATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFF 826

  Fly   914 AQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTEL 966
            :|...||:.|......||.:|...|..|:.|:..:.:|:::.|.:|.|:..||
  Rat   827 SQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAEL 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	74/230 (32%)
Pde2a	NP_001137319.1	GAF	235..382	CDD:214500	31/178 (17%)
		GAF	404..553	CDD:214500	36/186 (19%)
		PDEase_I	650..883	CDD:278654	74/230 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820