Protein Alignment Pde9 and Pde1c

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_112340.1
• Gene: Pde1c / 81742
• RGDID: 68332
• Length: 768
• Species: Rattus norvegicus
• Alignment Length: 833
• Identity: 191/833 - (22%)
• Similarity: 315/833 - (37%)
• Gaps: 230/833 - (27%)

  Fly   534 SNVDGDATATAATALSSTVGGG------IGGIGGSIKMRASATDIETNALNGARDAIVASNNGNN 592
            :|..||..|......|.:....      |.|:.|::|.:...|.::...   ..:.|:|
  Rat    30 ANEAGDKNARPLARFSRSKSQNCLWNSLIDGLTGNVKEKPRPTIVQDTR---PPEEILA------ 85

  Fly   593 GNNGNNGNNEYSILQLNNTIIQCHFNDDDFRALVK----------DLKRKVEY------------ 635
                    :|...|.....:::..|.   .|:|||          |||:.:||
  Rat    86 --------DELPQLDSPEALVKTSFR---LRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDE 139

  Fly   636 TERM--------------------NWLCLS-KRPLGPPHRKS-SLPKHQEV-------------K 665
            |.|:                    :||..: .|.:|...|:| ..|:.:.:             .
  Rat   140 TRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMY 204

  Fly   666 RRFLEICDTTFSEEVRAALR---LPAFDSYEWSDADVIHLMQTMFVEL----GFIEKFSIPVDTL 723
            ||...:...::...|..||:   ..:||.:..::|...|.::.:|.||    ..|.:|.||:..|
  Rat   205 RRTSNMVGLSYPPAVIDALKDVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISAL 269

  Fly   724 REWL--YEV--YKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDH 784
            ..::  .||  .||.|  |:||..|...|.|.::.:..:..:.:.|.:||...::.|...||.:|
  Rat   270 VSFVEALEVGYSKHKN--PYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEH 332

  Fly   785 PGYNNIYQINARTELALRYNDISPLENHHCSIAFRLL-EHPECNIFKNFSRDTFNNIREGIIRCI 848
            .|..|.:.|..|::.|:.|||.|.|||||.|.|:||| |..|.||..|.|:|.:...|..:|..:
  Rat   333 TGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMV 397

  Fly   849 LATDMARHNEILTQFMEITPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFF 913
            :||||:.|   ..|...:.................:::..||||:.|:..|:...|...||:|||
  Rat   398 MATDMSCH---FQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFF 459

  Fly   914 AQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEYY 978
            .|...|...|||.:|..|........|||.||..::.|.|..|    .::||.|:.|:
  Rat   460 RQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVL----TDMTEKIVSPL------- 513

  Fly   979 RRLNDAQTKTRKSVADSNTSATSD--SNSGTIDSNAAMVSTPGGASDKLSLDKGQGNSQGSGGGG 1041
              :::.          |.|..|..  |:..:|:|:.|..|
  Rat   514 --IDET----------SQTGGTGQRRSSLNSINSSDAKRS------------------------- 541

  Fly  1042 GGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISVKS----------------RRSIPSQKSA 1090
                |..:.|..||...:|   ||.|        :..||                |..:|.::.|
  Rat   542 ----GVKSSGSEGSAPINN---SVIP--------VDYKSFKATWTEVVQINRERWRAKVPKEEKA 591

  Fly  1091 SRTSVDEPGGMASELHDLPEGSESGDSETATEVDVAEKTSKFKVDTEGSSNRSKSSHSTSRKSSR 1155
            .: ..:|...:|:|             |...|::...:..      :|::::::      :|:|.
  Rat   592 KK-EAEEKARLAAE-------------EKQKEMEAKSQAE------QGTTSKAE------KKTSG 630

  Fly  1156 EKRPSMIGELCSSGGGQRIRNSYGNIHG--YHSNRCHFGNNRAVSLDQYSSAGNNRRLSDG---- 1214
            |.:..:.|...|.|...|.:||.|:..|  ..:.....|.|:|...| :|:.||..:.:||
  Rat   631 ETKGQVNGTRTSKGDNPRGKNSKGDKAGEKQQNGDLKDGKNKADKKD-HSNTGNESKKADGTKKR 694

  Fly  1215 -----LPQVISDSNVFYG------RHNR--SSTETTVAVGNPQDTNANTNHPV 1254
                 .|...|.|.:...      ||.:  :...::.|...|:.|:   :|||
  Rat   695 SHGSPAPSTSSTSRLTLPVIKPPLRHFKRPAYASSSYAPSVPKKTD---DHPV 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	75/228 (33%)
Pde1c	NP_112340.1	PDEase_I_N	146..202	CDD:285672	7/55 (13%)
		PDEase_I	287..515	CDD:278654	77/243 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	513..557		13/94 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	584..719		31/161 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920