Protein Alignment Pde9 and Pde1a

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_063140682.1
• Gene: Pde1a / 81529
• RGDID: 68329
• Length: 565
• Species: Rattus norvegicus
• Alignment Length: 543
• Identity: 142/543 - (26%)
• Similarity: 223/543 - (41%)
• Gaps: 137/543 - (25%)

  Fly   534 SNVDGDATATAATALSSTVGGGIGGIGGSIKMRASATDIETNALNGARDAIVASNNGNNGNNGNN 598
            :::||.       .||.|..|.:    |:|.|.::.|||| ...|.....::
  Rat     4 ASLDGH-------TLSITTCGAL----GNIIMGSTDTDIE-ELENATYKYLI------------- 43

  Fly   599 GNNEYSILQLNNTIIQCHFNDDDFRALVK----------DLKRKVEY------------TERM-- 639
            |.....:.|....|::|         |||          |||:.:||            |.|:
  Rat    44 GEQTEKMWQRLKGILRC---------LVKQLEKGDVNVVDLKKNIEYAASVLEAVYIDETRRLLD 99

  Fly   640 ------------------NWLCLS-KRPLGPPHRK-SSLPKHQEV-------------KRRFLEI 671
                              :||..: .|.:|...:| ...||.:.:             .|:...:
  Rat   100 TEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKNYHM 164

  Fly   672 CDTTFSEEVRAALRLP---AFDSYEWSDADVIHLMQTMFVEL----GFIEKFSIPVDTL---REW 726
            ...|:...|...|:..   :||.:..::|...|.::.|..||    ..|.:|.|||..|   .|.
  Rat   165 VGLTYPAAVIVTLKEVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIAFAEA 229

  Fly   727 LYEVY-KHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNI 790
            |...| ||.|  |:||..|...|.|.::.|.....::..|.:||.|.::.:...||.:|.|..|.
  Rat   230 LEVGYSKHKN--PYHNLVHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAVHDYEHTGTTNN 292

  Fly   791 YQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMAR 855
            :.|..|:::|:.|||.|.|||||.|.|:||::..|.||..|.|:|.:.::|..:|..:|||||:.
  Rat   293 FHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILVNLSKDDWRDLRNLVIEMVLATDMSG 357

  Fly   856 HNEILTQFMEITPIFDYSNRAHIN--------LLCMILIKVADISNEARPMDVAEPWLDRLLQEF 912
            |      |.:|..|     |:.:.        ....:::..||||:.|:...:...|...|::||
  Rat   358 H------FQQIKNI-----RSSLQQPEGIDRAKTMSLILHAADISHPAKTWKLHYRWTMALMEEF 411

  Fly   913 FAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEY 977
            |.|...|...|||.:|..|........||:.||..::.|.|    .|:.:.||.|:||
  Rat   412 FLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTF----SLLTDSTEKIVIP------- 465

  Fly   978 YRRLNDAQTKTRKSVADSNTSAT 1000
               |.:..:|...|...:::|:|
  Rat   466 ---LIEEASKPESSNYGASSSST 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	75/235 (32%)
Pde1a	XP_063140682.1	None