DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde9 and pde4b

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	XP_031756141.1	Gene:	pde4b / 780324	XenbaseID:	XB-GENE-963512	Length:	733	Species:	Xenopus tropicalis

Alignment Length:	279	Identity:	89/279 - (31%)
Similarity:	151/279 - (54%)	Gaps:	16/279 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   702 LMQTMFVELGFIEKFSIPVDTLREWLYEVYKHY-NEVPFHNFRHCFCVAQMMYAITRQANLLSRL 765
            :|..:|.|...::.|.||.|||..:...:..|| ::|.:||..|...|.|..:.:.....|.:..
Frog   365 IMYAIFQERDLLKTFKIPADTLITYTMTLEDHYHSDVAYHNSLHAADVTQSTHVLLSTPALDAVF 429

  Fly   766 GDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFK 830
            .|||.|..:.:...||:||||.:|.:.||..:||||.|||.|.|||||.::.|:||:...|:||:
Frog   430 TDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQ 494

  Fly   831 NFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITP-----------IFDYSNRAHINLLCMI 884
            |.::....::|:.:|..:|||||::|..:|.....:..           :.:|::|..:   ...
Frog   495 NLTKKQRQSLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQV---LRN 556

  Fly   885 LIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVL 949
            ::..||:||..:.:::...|.||:::|||.|...|:..|:.::|..|....|...|||.||..::
Frog   557 MVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIV 621

  Fly   950 LPLFEALGELV-PELTELI 967
            .||:|...:|| |:..:::
Frog   622 HPLWETWADLVQPDAQDIL 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	77/239 (32%)
pde4b	XP_031756141.1	PDE4_UCR	164..279	CDD:407935
pde4b	XP_031756141.1	PDEase_I	403..644	CDD:395177	77/241 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920