DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pde9 and pde5a

DIOPT Version :9

Sequence 1:NP_727644.3 Gene:Pde9 / 32233 FlyBaseID:FBgn0259171 Length:1623 Species:Drosophila melanogaster
Sequence 2:XP_012821480.2 Gene:pde5a / 780273 XenbaseID:XB-GENE-479676 Length:943 Species:Xenopus tropicalis


Alignment Length:945 Identity:197/945 - (20%)
Similarity:326/945 - (34%) Gaps:284/945 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   218 ILLRHSIFDP----------------GKE-HQRAIVLAAATAAIAGPLAAIDCVCGSSSISLEAV 265
            :|..||.:.|                ||. .|..:...|:.||:..||||               
 Frog    36 LLFIHSSYVPPPCALFFRRFPSPACLGKRMWQGNLYREASVAAVGFPLAA--------------- 85

  Fly   266 SSRSRSSELEDDHHEQDQVQEEQEQEQHQGDTEDN---------EE-------EQEH--PSEKPE 312
                 :.|:.|    ..:.|.|.....|......:         :|       |:.|  |:.|.:
 Frog    86 -----APEMGD----TPEPQVENWAATHSATVNSSCNAHACCTLQEMVNAWFAERVHTIPASKEQ 141

  Fly   313 RTDIEEEPPPAIAVTTTTTATVRRKSSSS------------STISGTATVSGS----------VS 355
            ..:..|..|.......||..|..||.|:|            .::.....:|.|          .|
 Frog   142 GKNNSESNPQVCYSENTTQGTPVRKISASEFDRPLRPIVVKDSVGTLKFLSDSEKKELMPLQPPS 206

  Fly   356 VSASASQSFCSNNINLLEELLIQFYEEQDHRSNLTVIRH----HHHQQHQQHQQQQRITNNNNNN 416
            :|.:..|  ||..:.|::::        ....::|.:.|    |.|:.....:....:...:::|
 Frog   207 LSRAGDQ--CSRLLELVKDI--------SSHLDVTTLCHKIFLHIHELIAADRYSLFLVCEDSSN 261

  Fly   417 ---------------------NNCNSIQNNNNMSNPAATAAATATPSVEQPATSGTTNIHLQPTS 460
                                 |||..::.|..:              |...|..|      ||.:
 Frog   262 KKFLVSRLFDVAEGTTVEQASNNCIRLEWNKGI--------------VGHVAEFG------QPLN 306

  Fly   461 LPDGSDNPRRRRASDCSAVQAALQNQLHCITLKNNN---CGKAMPFHRGS--------------- 507
            :.|...:.|..  ::...:.......:.|:.:||:.   .|.|...::.|               
 Frog   307 IKDAYQDSRFN--AEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGSNGTFTDQDEKDFA 369

  Fly   508 -----CGAA--GEHLLAANSIANR--------ATIILSKSCSNVDGDATATAATALSSTVGGGIG 557
                 ||..  ...|...:.:.||        ||:|..:. .:::......|||.||.       
 Frog   370 AYLAFCGIVLHNAQLYETSLLENRRNQVLLDLATLIFEEQ-QSLEVILKKIAATILSF------- 426

  Fly   558 GIGGSIKMRA-----------------SATDIETNALNGARDAI-----VASNN----------- 589
                   |:|                 |...:|::.|..:.||:     |:..|           
 Frog   427 -------MQAQRCTIFIVDEDSPDTFSSVFHMESDELEESADAVKREYDVSKMNYMYAQYVANTM 484

  Fly   590 ---------------GNNGNNGNNGNNEYSIL-------QLNNTIIQCHFND--DDFRALVKDL- 629
                           ..|||...|..:..|:|       :.|..|..|...:  |:....:|.. 
 Frog   485 EAINIPDICKDTRFPWTNGNEEKNFKHIQSLLCSPIKNAKKNKVIGVCQLVNKVDENSGKIKAFN 549

  Fly   630 KRKVEYTERMNWLCLSKRPLGPPHRKSSLPKHQEVKRRF------LEIC--------DTTFSEEV 680
            |...::.|.....|    .||..:.:    ..:.|:|..      |||.        :.|...:|
 Frog   550 KNDEQFLEAFAIFC----GLGIQNTQ----MFEVVERAMAKQMVTLEILSYHASAAEEETMELQV 606

  Fly   681 RAALRLPA----------FDSYEWSDADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYN 735
            .|...:|:          |..:|.||.:.......||.:|..::.|.:..:||..|:..|.|:|.
 Frog   607 TAGAIVPSAQSLKLTEFYFSDFELSDMETTLATSRMFTDLNLVQTFQMKYETLCRWILSVKKNYR 671

  Fly   736 E-VPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTEL 799
            : |.:||:||.|..||.|:|..|...:..:|.|||.|.|:::.:.|||||.|.||.:...:...|
 Frog   672 KNVAYHNWRHAFNTAQCMFAALRTGKIQGKLNDLEILALMIATLSHDLDHRGVNNSFIQRSEHPL 736

  Fly   800 ALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFM 864
            |..|.. |.:||||......:|......|....|...:..:.:.|.:.|||||:|.:.:..:.|.
 Frog   737 AQLYCH-SIMENHHFDQCLMILNSQGNQILSGLSVQDYKTVLKMIKQAILATDLALYIKRRSDFF 800

  Fly   865 EIT--PIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVT 927
            |:.  ..|.:.:.:...|...:|:...|:|...:|..|.:...:.:..||:.|...|:.| |.:.
 Frog   801 ELVNKKKFKWDDPSQKELFLAMLMTACDLSAITKPWPVQQRIAELVASEFYDQGDKERRE-LNIE 864

  Fly   928 P--FMDPDKVSK-PGSQVRFIGLVLLPLFEALGEL 959
            |  .|:.:|..| |..||.||..|.|.|:|||.::
 Frog   865 PIDLMNREKKDKIPSMQVGFIDAVCLELYEALTQI 899

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde9NP_727644.3 PDEase_I 739..967 CDD:278654 72/226 (32%)
pde5aXP_012821480.2 GAF 229..386 CDD:214500 25/178 (14%)
GAF 412..577 CDD:214500 30/186 (16%)
PDEase_I 676..911 CDD:395177 72/226 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D904682at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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