Protein Alignment Pde9 and Pde10a

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_038945075.1
• Gene: Pde10a / 63885
• RGDID: 68434
• Length: 1075
• Species: Rattus norvegicus
• Alignment Length: 294
• Identity: 86/294 - (29%)
• Similarity: 143/294 - (48%)
• Gaps: 15/294 - (5%)

  Fly   720 VDTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDH 784
            ::.|..::..|.|:|..||:||::|...||..||||.:..|.|  ..|||...||::|:||||||
  Rat   786 LEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNGL--FTDLERKGLLIACLCHDLDH 848

  Fly   785 PGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCIL 849
            .|::|.|.......||..|: .|.:|.||.|....:|:....|||...|...:..:.|.|.:.|:
  Rat   849 RGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAII 912

  Fly   850 ATDMARH--NEILTQFMEITPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEF 912
            |||:|.:  |....:.|..|...:..|::|.:.:..:::...|:.:..:...|.:...:.:..||
  Rat   913 ATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEF 977

  Fly   913 FAQSAAEKSEGLPVTPFMDPDKVSK-PGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALE 976
            :|:....|..|:...|.||.||..: |..|:.|...|.:|.:..|.:::|. ||.::...|..|.
  Rat   978 WAEGDEMKKLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTTLTQILPP-TEPLLKACRDNLN 1041

  Fly   977 YYRR-LNDAQT-------KTRKSVADSNTSATSD 1002
            .:.: :...:|       .|.||.::..|....|
  Rat  1042 QWEKVIRGEETAMWISGPATSKSTSEKPTRKVDD 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	72/230 (31%)
Pde10a	XP_038945075.1	GAF	<356..>540	CDD:441805
		GAF	558..713	CDD:214500
		PDEase_I	805..1036	CDD:459723	72/234 (31%)