Protein Alignment Pde9 and pde4a

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_009298019.1
• Gene: pde4a / 572061
• ZFINID: ZDB-GENE-131125-7
• Length: 777
• Species: Danio rerio
• Alignment Length: 685
• Identity: 156/685 - (22%)
• Similarity: 255/685 - (37%)
• Gaps: 190/685 - (27%)

  Fly   385 HRSNLTVIRHHHHQQHQQHQQQQRITNNNNNNNNCNSIQNNNNM---SNPAATAAATATPSVEQP 446
            ||......||||.|                       |:.:|.|   ..|....:..:.||
Zfish    44 HRGYSDTDRHHHRQ-----------------------IERSNAMDTSDRPGLKKSRMSWPS---- 81

  Fly   447 ATSGTTNIHLQ---PTSLPDGSDNPRRRRASDCSAVQAAL-------QNQLHCITLKNNNCGKAM 501
            :..|||:..:.   .....||.:.|...|:...|.....|       |:|
Zfish    82 SFHGTTSASMSNCAGNKRYDGENGPSPGRSPMDSQASPGLVLHPSFPQSQ--------------- 131

  Fly   502 PFHRGSCGAAGEHLLAANSIANRATIILSKSCS-NVDGDATATAATALSSTVGGGIGGIGGSIKM 565
              .|.|      .|..::|..:.:...:|::.| |.:|.|.....|..:..: ..:..:..:..:
Zfish   132 --RRES------FLYRSDSDYDMSPKTMSRNSSINSEGHAEDLIVTPFAQVL-ASLRTVRSNFTI 187

  Fly   566 RASATDIETNALNGARDAIVASNNGNNGNNGNNGNNEYSILQLNNTIIQCHFNDDDFRALVKDLK 630
            .|:.|...|.    .|..:.:                      ..|:.....:|:.::.|.:
Zfish   188 LANVTTPTTT----MRSPVTS----------------------QPTVPPATLSDETYQQLAR--- 223

  Fly   631 RKVEYTERMNWLCLSKRPLGPPHRKSSLPKHQEVKR-----------------RFLEICDTTF-- 676
               |..|.::| ||.:......||..|.....:.||                 :..|...|||
Zfish   224 ---ETLEELDW-CLDQLETIQTHRSVSEMASNKFKRMLNRELSHLSEMSRSGNQVSEYISTTFLD 284

  Fly   677 -SEEVR----------------------------AALRLPAF---------------DSYEWSDA 697
             ..||.                            .:..||.|               |..:|. .
Zfish   285 KQNEVEIPSPTLREREKPMSHISGVKKLTHSSSLTSAALPRFGVKTEQEDALARELNDLNKWG-L 348

  Fly   698 DVIH------------LMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYN-EVPFHNFRHCFCVA 749
            ::.|            :|..:|.|...::.|.|||||...::..:..||: .|.:||..|...|.
Zfish   349 NIFHVAEFSNNRPLSCIMFAIFQERDLLKTFRIPVDTFITYVMTLEDHYHANVAYHNSLHAADVT 413

  Fly   750 QMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHC 814
            |..:.:.....|.:...|||.|..|.:...||:||||.:|.:.||..:||||.|||.|.|||||.
Zfish   414 QSTHVLLSTPALDAVFSDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL 478

  Fly   815 SIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFME-----------ITP 868
            ::.|:||....|:||:|.::....::|:.:|..:|||||::|..:|.....           :..
Zfish   479 AVGFKLLHEENCDIFQNLTKRQRQSLRKLVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLM 543

  Fly   869 IFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPD 933
            :..|::|..:   ...::..||:||..:|:.|...|.:|:::|||.|...|:..|:.::|..|..
Zfish   544 LDHYNDRIQV---LRNMVHCADLSNPTKPLAVYRQWTERIMEEFFQQGDKERERGMEISPMCDKH 605

  Fly   934 KVSKPGSQVRFIGLVLLPLFEALGELV-PELTELI 967
            ..|...|||.||..::.||:|..|:|| |:..|::
Zfish   606 TASVEKSQVGFIDYIVHPLWETWGDLVHPDAQEIL 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	81/239 (34%)
pde4a	XP_009298019.1	PDE4_UCR	168..284	CDD:465648	22/149 (15%)
		PDEase_I	403..643	CDD:459723	81/241 (34%)