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Protein Alignment Pde9 and pde8b

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	XP_009293455.1	Gene:	pde8b / 571011	ZFINID:	ZDB-GENE-091117-3	Length:	874	Species:	Danio rerio

Alignment Length:	865	Identity:	199/865 - (23%)
Similarity:	331/865 - (38%)	Gaps:	232/865 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 RTDIEEEPPPAIAVTTTTTAT----VRRKSSSSSTISGTATVSGSVSVSASASQSFCSNNINLLE 373
            :||..:..|..||..|..|.|    .||::|.....:...|.:...||..|.::... ..:.|..
Zfish    46 KTDAADTIPSVIAYQTRHTRTNSHRERRENSGGQMCTEAETQTSCTSVKVSGAEDRL-GPMRLSH 109

  Fly   374 E---LLIQFYEEQDH---------------------RSNLTVIRHHHHQ------QHQQHQQQQR 408
            |   :|:.|.:|...                     .|.|......||:      :|.::.:.:.
Zfish   110 EPIQVLLVFAKEDSQSDAFWWACERAAFRCNIARTPESALECFLDKHHEIVIIDGRHPRYFEAEA 174

  Fly   409 ITNNNNNNNNCNSIQNNNNMSNPAATAAATATPS-VEQPA-----TSGTTNIHLQPTS------- 460
            |         |..|:......:....|....||| .|:|:     ::|.:..:|:.:|
Zfish   175 I---------CRMIRATKLSEHTVILAVMPQTPSDQEEPSVLPLLSAGFSRRYLENSSVSACYNE 230

  Fly   461 ---LPDGSDNPR-RRRASDCSAVQAALQ---------NQLHCITLKNNNCGKAMPFHRGSCGAAG 512
               |..|....: :.||  |:||..||:         ::.|.|...|....|.|.:|||.  ..|
Zfish   231 LIQLEHGEVRAQFKLRA--CNAVFTALEQCQEAVEISSEDHVIQYVNPAFEKMMGYHRGE--LIG 291

  Fly   513 EHLL-AANSIANRATII-LSKSC-------------SNVDGDATATAATALSSTVGGGIGGIGGS 562
            :.|. ...|..|.|.:: ...:|             ....|| :......::..||.| |.|...
Zfish   292 KELTELPRSDKNSADLLDTINTCIKKGKEWQGIYFSRRKSGD-SIQQYVKITPVVGQG-GKIRHF 354

  Fly   563 IKMRASATD--------------------IETNAL---NGARDAI-VASNNGNNGNNGNNGNNEY 603
            :.::...:|                    .|.|:|   :..:::: |.|.:.::.:..:..|..|
Zfish   355 VSIKRPYSDNHRQVHKLSKEEKCCGEHSQSECNSLRHKDRRKESVDVRSISSHSSDAPSLQNRRY 419

  Fly   604 S--------------------------------------ILQLNNTI----IQCHFNDDD----- 621
            |                                      :|::..|.    .|....:||
Zfish   420 SSMARIHSMTIEAPITKVINIINAAQESSPVTVAEALDRVLEILRTTELYSPQLASKEDDPHTND 484

  Fly   622 -FRALVKDLKRKV---EYTERMNWL-CLSKRPLG--------PPHRKSSLPKHQEVKRRFLEICD 673
             ...|:.|..|::   ||....:.| .:|:..||        ||.....|.:.::.:...||:..
Zfish   485 LVGGLMSDGLRRLSGNEYIFSKSALQNMSQSQLGVPVPLNDIPPSIAELLNEEEQWEFNILELEA 549

  Fly   674 TTFSEEVRAALRLPAFDSYEWSDADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEV- 737
            .|....:          ||         |...:|...|..|..:....|||.||..:..:|:..
Zfish   550 ATHKRPL----------SY---------LGLKIFSAFGVCEFLNCSESTLRLWLQVIETNYHSSN 595

  Fly   738 PFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALR 802
            .:||..|...|........|:..:.:.|..|:.:..|::...||:||||..|.:..||.:|||:.
Zfish   596 SYHNSTHAADVLHATAYFLRKERVKASLDQLDEVAALLAATVHDVDHPGRTNSFLCNAGSELAIL 660

  Fly   803 YNDISPLENHHCSIAFRL-LEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFME- 865
            |||.:.||:||.::||:| :...:||||||..|..|..:|:.||..:|||:|.||.|.:.:|:.
Zfish   661 YNDTAVLESHHAALAFQLTVRDSKCNIFKNMERTQFRTLRQAIIDMVLATEMTRHFEHVNKFVNS 725

  Fly   866 ----ITPI---------FDYSNRAHIN-------LLCMILIKVADISNEARPMDVAEPWLDRLLQ 910
                ::.|         .|...:|.|.       |:..:|||.||::|..||:::...|..|:.:
Zfish   726 INKPMSAIEETSSNSEGSDCEGQASIRNSPENRLLIKRMLIKCADVANPCRPLELCIEWAGRISE 790

  Fly   911 EFFAQSAAEKSEGLPVT-PFMDPDKVSKPGSQVRFIGLVLLPLFEA------LGELVPELTELII 968
            |:|||:..||.:||||. |..|.:..|.|.||:.||...:..:|:|      |..|:..|.|
Zfish   791 EYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFASLPGLMEHLAE--- 852

  Fly   969 IPVRIALEYYRRLNDAQTKT 988
                 ..:|::.|::.:.|:
Zfish   853 -----NYKYWKNLDEMKCKS 867

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.