Protein Alignment Pde9 and pde3a

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_009298269.1
• Gene: pde3a / 567051
• ZFINID: ZDB-GENE-041210-23
• Length: 1124
• Species: Danio rerio
• Alignment Length: 959
• Identity: 194/959 - (20%)
• Similarity: 313/959 - (32%)
• Gaps: 293/959 - (30%)

  Fly   295 GDTEDNEEEQEHPSEK---PERTDIEEEPPPAI------AVTTTTTAT---------VRRKSS-- 339
            |.|..:.||.....|:   |:|  :.....|.:      ..||||:||         |||..|
Zfish   346 GHTCSDSEEAPEKGERLAIPKR--LRRSLHPGLLRRISSTWTTTTSATGLPTLEPGPVRRDRSAS 408

  Fly   340 --------SSSTI-------SGTATVSGSVSVSASASQSFCSNNINLLEELLIQFYEEQDHRSNL 389
                    |||.:       |...::|.|.|:|||.:.|  ||..|       ..|.:.....:.
Zfish   409 IKAPHDGPSSSLVNSDSWNNSNMLSISKSRSMSASYAAS--SNTTN-------HIYSKSRRGCSS 464

  Fly   390 TVIRHHHHQQHQQHQQQQRITNNNNNNNNCNSIQNNNNMSNPAATAAATATPSVEQPATSGTTNI 454
            :.|.......|....|...:|:..|.                        |||||.|
Zfish   465 STISPLASPCHSPPVQSSPLTSPTNK------------------------TPSVELP-------- 497

  Fly   455 HLQPTSLPDGSDNPRRRRASDCSAVQAALQNQLHCITLKNNNCGKAMPFHRGSCGAAGEHLLAAN 519
              .|...|..|.:.....:....:..|||...   .|...::||:.....|.|.|        :.
Zfish   498 --DPELPPPRSPHKALTHSQSAPSSSAALWPP---PTPLCSSCGRPYSKQRHSDG--------ST 549

  Fly   520 SIANRATIILSKSCSNVDGDATATAATALSSTVGGGIGGIGGSIKMRASATDIETNALNGARDAI 584
            ..|.|..          ..|..|..::...||                    .|||
Zfish   550 EPAERTQ----------QSDEPAMMSSDYDST--------------------YETN--------- 575

  Fly   585 VASNNGNNGNNGNNGNNEYSILQLNNTIIQCHFNDDDFRALVKDLKRKVEYTERMNWLCLSKRPL 649
                                           |.:..||....:|  |:...|       |:...|
Zfish   576 -------------------------------HSDSSDFAQTDED--REARRT-------LTLATL 600

  Fly   650 GPPHRKSSLPKH----QEVKRRFLEICDTTFSEEVRAALRLPAFDSYEWSDAD----VIHLMQTM 706
            .|...|..|...    :.::....:|.:..|          |.|...|.::..    :..:...:
Zfish   601 IPAEEKPILAPEPLLMEGLEPLLCQINNWNF----------PIFSLVEKTNGRCGCILSQMSYRL 655

  Fly   707 FVELGFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAIT--------------- 756
            ||:.|..|.|.|||.....:.:.:...|.::|:||..|...|...::.:|
Zfish   656 FVDTGLFETFKIPVREFMNYFHALENGYRDIPYHNRIHATDVLHAVWYLTTQPVPGLPTLRTLGS 720

  Fly   757 ----------RQANLLSR---------------LGDLECLILLVSCICHDLDHPGYNNIYQINAR 796
                      |...|:||               :..||.:.|.|:...||.||||..|.:.:...
Zfish   721 SDSDSGLAHGRMKYLMSRTNAVEEEGYGCLSGLIPALELMALYVAAAMHDYDHPGRTNAFLVATS 785

  Fly   797 TELALRYNDISPLENHHCSIAFRL-LEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEIL 860
            ...|:.|||.|.|||||.:.|:.| :..||.|...:.....|...|..:|..|||||:.:|.:.|
Zfish   786 APQAVLYNDRSVLENHHAASAWNLFMSRPEYNFLASLDHMEFKRFRFLVIEAILATDLKKHFDFL 850

  Fly   861 TQFM-----EITPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEK 920
            .:|.     :.....|::|.....|:|.:.||:|||:...:..|:...|.:.::.||:.|...|.
Zfish   851 AEFNAKVGDDGCSGIDWTNENDRLLVCQMCIKLADINGPLKCKDLHLQWTEGIVNEFYEQGDEES 915

  Fly   921 SEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEYYRRLNDAQ 985
            |.|||::||||.........|..||..:       :|.|........::|.|......:..::.:
Zfish   916 SLGLPISPFMDRSAPQLAKLQESFITHI-------VGPLCSSYDSAALMPGRWVHPLPKDGDEVE 973

  Fly   986 TKTRKSVADSNTSATSDSNSGTIDSNAAMVSTPGGAS-----------------DKLSLDKGQGN 1033
            .::.:.  |.:|:...:.::.| .|..:....|....                 .|:..::.|..
Zfish   974 DESEEE--DEDTAEEEEEDAST-SSELSQKPAPKKRRKVFCQISHHLLENHEMWKKVIAEESQSQ 1035

  Fly  1034 SQGSGGGGGGGGGGGAGGGTGSGCGSNAAG---SVSPQMPRSGSGISVKSRRSIPSQKSASRTSV 1095
            ::|.                .|.|.|....   ::..:....||       :..|:......::.
Zfish  1036 TEGE----------------ESTCLSTTPEPILAIDEEEEEPGS-------KEEPTDDQGEGSTE 1077

  Fly  1096 DEPGGMASELHDLPEGSESGDSETATEVDVAEKTSKFKVDTEGSSNRSK 1144
            :|.|.:..:.|:    ::..|.||..|.|  ||.::...|.||..:..:
Zfish  1078 EEEGPVPEDTHE----TQEPDGETVEEAD--EKNTETVEDIEGKQDEDQ 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	74/273 (27%)
pde3a	XP_009298269.1	PDEase_I	688..947	CDD:459723	73/265 (28%)