DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde9 and pde4ba

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	XP_021332832.1	Gene:	pde4ba / 565706	ZFINID:	ZDB-GENE-030131-9570	Length:	734	Species:	Danio rerio

Alignment Length:	742	Identity:	161/742 - (21%)
Similarity:	274/742 - (36%)	Gaps:	244/742 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   530 SKSCSNVDGDATATAATALSSTVGGGIGGIGGSIKMR-----ASATDIETNALNGARDAIVASN- 588
            |.|||.:|..|:..:...|.:       ...|..:.|     .|.:|.:.:..:.:|::.|||.
Zfish   102 SASCSPLDPQASPGSGLVLHT-------NFPGHNQRRESFLYRSDSDYDLSPKSMSRNSSVASEL 159

  Fly   589 NGNN---------GNNGNNGNNEYSILQLNNTIIQCHFN-----------------DDDFRALVK 627
            :|::         ..:..:..|.:::|    |.:||..|                 |:.::.|.
Zfish   160 HGDDLIVTPFAQVLASLRSVRNNFTVL----TNVQCTSNKRSPVSNQPSITRVCLPDESYQKLA- 219

  Fly   628 DLKRKVEYTERMNWLCLSKRPLGPPHRK------------------------------------- 655
                 ||..|.::| ||.:......:|.
Zfish   220 -----VETMEELDW-CLDQLETIQTYRSVSDMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNT 278

  Fly   656 -----------SSLPKHQEVKRR---FLEI-------------C-----------DTTFSEEVRA 682
                       |..||.:|.|::   ..:|             |           :...|:|:..
Zfish   279 FLDKQNDVEIPSPTPKAREKKKKQQLMTQISGVKKVSHGPSLNCGIARFGVKTDKEDLLSKELED 343

  Fly   683 ALR--LPAFDSYEWS-DADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYN-EVPFHNFR 743
            ..|  |..|...|:| :..:..:|..:|.|...::.|.||.||...::..:..||: :|.:||..
Zfish   344 LNRWGLNIFTVSEYSNNRPLTCIMYAIFQERDLLKTFKIPTDTFVTYMMTLEDHYHQDVAYHNSL 408

  Fly   744 HCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISP 808
            |...|||..:.:.....|.:...|||.|..:.:...||:||||.:|.:.||..:||||.|||.|.
Zfish   409 HAADVAQSTHILLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 473

  Fly   809 LENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITP----- 868
            |||||.::.|:||:...|:||:|.::....::|..:|..:|||||::|..:|.....:..
Zfish   474 LENHHLAVGFKLLQEDNCDIFQNLTKKQRTSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVT 538

  Fly   869 ------IFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVT 927
                  :.:|::|..:   ...::..||:||..:.:::...|.||:::|||.|...|:..|:.::
Zfish   539 SSGVLLLDNYTDRIQV---LRNMVHCADLSNPTKSLELYRQWTDRIMEEFFHQGDRERERGMEIS 600

  Fly   928 PFMDPDKVSKPGSQVRFIGLVLLPLFEALGELV-PELTELIIIPVRIALEYYRRLNDAQTKTRKS 991
            |..|....|...|||.||..::.||:|...:|| |:..:::           ..|.|.:...:..
Zfish   601 PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQDIL-----------DTLEDNRNWYQSM 654

  Fly   992 VADSNTSATSDSNSGTIDSNAAMVSTPGGASDKLSLDKGQGNSQGSGGGGGGGGGGGAGGGTGSG 1056
            :..|                   .|.|....||          :|:||..|
Zfish   655 IPQS-------------------PSPPFYQPDK----------EGNGGSSG-------------- 676

  Fly  1057 CGSNAAGSVSPQMPRSGSGISVKSRRSIPSQKSASRTSVDEPGGMASELHDLPEGSE-----SGD 1116
                                        |.:.....|..:|..          ||:|     .||
Zfish   677 ----------------------------PDKFQFELTLEEEDS----------EGTEKDEQSQGD 703

  Fly  1117 SETATEVDVAEK---TSKFKVDTEGSS 1140
            .|...|.|..|:   |:..::.||.:|
Zfish   704 EEEEAEEDRGEEMESTTHIQIVTEDAS 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	78/239 (33%)
pde4ba	XP_021332832.1	PDEase_I	404..641	CDD:306695	78/239 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920