Protein Alignment Pde9 and pde1a

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_073769263.1
• Gene: pde1a / 564465
• ZFINID: ZDB-GENE-090831-2
• Length: 672
• Species: Danio rerio
• Alignment Length: 626
• Identity: 155/626 - (24%)
• Similarity: 249/626 - (39%)
• Gaps: 167/626 - (26%)

  Fly   623 RALVK----------DLKRKVEY------------TERM--------------------NWLC-- 643
            |.|||          ||::.:||            |.|:                    :||.
Zfish   105 RCLVKQLDKGEVNVVDLRKNIEYAASVLEAVYIDETRRLLDTEDELSDIQADSVPMEVRDWLAST 169

  Fly   644 -------LSKRPLGPPHRKSSLPKHQ------EVKRRFLEICDTTFSEEVRAALR---LPAFDSY 692
                   :.:||...|..:|.:...|      .:.||...:...|:...|..||:   ..:||.:
Zfish   170 FTRKMGVVRRRPEEKPRFRSIVHAVQAGIFVERMYRRTSNMAGLTYPPSVITALKDVDKWSFDVF 234

  Fly   693 EWSDADVIHLMQTMFVEL----GFIEKFSIPVDTLREWLYEV----YKHYNEVPFHNFRHCFCVA 749
            :..:|...|.::.:..||    ..|.:|.|||.:|..::..:    .||.|  |:||..|...|.
Zfish   235 KLQEASSDHALKFLVYELLTRYDLISRFRIPVSSLVSFVEALEIGYSKHRN--PYHNLIHAADVT 297

  Fly   750 QMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHC 814
            |..:.:.....::..|.:||.|.::.:...||.:|.|..|.:.|..|:|:|:.|||.|.|||||.
Zfish   298 QTAHYLMLHTGVMHWLTELEILAMVFAAAIHDFEHTGTTNNFHIQTRSEVAILYNDRSVLENHHV 362

  Fly   815 SIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARH-NEILTQFMEITPIFDYSNRAHI 878
            |.|:||::..|.||..|.|:|.:..:|..:|..:::|||:.| .:|.|....:...........:
Zfish   363 SAAYRLMQEDEMNILVNLSKDDWRELRTLVIEMVMSTDMSCHFQQIKTMRNSLQQPEGIDKAKAL 427

  Fly   879 NLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVR 943
            :|    ::..||||:.|:...:...|...|::|||.|...|...|||.:|..|........||:.
Zfish   428 SL----MLHAADISHPAKGWKLHYRWTQALMEEFFRQGDKEAELGLPFSPLCDRKATMIAQSQIG 488

  Fly   944 FIGLVLLPLFEALGELVPELTELIIIPVRIALEYYRRLNDAQTKTRKSVADSNTSATSDSNSGTI 1008
            ||..::.|.|..|    .:.||.||.|:                ..::|.......:|.:..|
Zfish   489 FIDFIVEPTFSVL----VDTTEKIISPL----------------IEEAVKSGGVRRSSLTGRG-- 531

  Fly  1009 DSNAAMVSTPGGASDKLSLDKGQGNSQGSGGGGGGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSG 1073
              :||:|.:....||:                           |:...||.:...|:
Zfish   532 --SAAVVESVQRHSDR---------------------------GSNDECGGSTDYSL-------- 559

  Fly  1074 SGISVKSRRSIPS---QKSASR---TSVDEPGGMASELH----DLPE----------GSESGDSE 1118
            .||..|..|.:.|   |.:..|   .||.|   :|::.|    ||.|          ..|:.|||
Zfish   560 CGIDQKHVRHLLSEIIQNNKERWKELSVQE---LANKQHERMSDLQEEPMRSTQLTLSQENHDSE 621

  Fly  1119 TAT--EVDVAEKT--SKFKVD------TEGSSNRSKSSHST 1149
            :.:  |::..:.|  |:..:|      |||:.:.|...||:
Zfish   622 SKSLNELNNTDSTHSSQDSLDQSSQSPTEGAGDASPEEHSS 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	72/228 (32%)
pde1a	XP_073769263.1	None