DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and pde3b

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	XP_691883.4	Gene:	pde3b / 563432	ZFINID:	ZDB-GENE-160728-20	Length:	1103	Species:	Danio rerio

Alignment Length:	742	Identity:	161/742 - (21%)
Similarity:	253/742 - (34%)	Gaps:	215/742 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 EQEHPSEKPERTDIEEEPPPAIAVTTTTTATVRRKSSSSSTISGTATVSG-----SVSVSASASQ 362
            |.:.|||:.||     :|...::...:......|:||:||::......|.     :...|.|...
Zfish   386 EMDDPSERGER-----KPVKGLSSRNSLPTPQLRRSSASSSLPPLDPASSRWERTNGKRSHSELS 445

  Fly   363 SFCSNNINLLEELLIQFYEEQDHRSNLTVIRHHHHQQHQQHQQQQRITNNNNNNNNCNSIQNNNN 427
            ||.||..|                |||..|         ..|:...:|           :...:.
Zfish   446 SFVSNGPN----------------SNLLTI---------PKQRSSSVT-----------LSYGHT 474

  Fly   428 MS-NPAATAAAT--ATPSVEQPATSGTTNIHLQPTSLPDGSDNPRRRRASDCSAVQAALQNQLHC 489
            :| .|.|:.:.:  .:||...||..|::.:...|...||.:|                      .
Zfish   475 LSRRPGASPSLSPVTSPSHSPPAGPGSSLVTRSPVEFPDTAD----------------------F 517

  Fly   490 ITLKNNNCGKAMPFHRGS---------------CGAAGEHLLAANSIANRATIILSKSCSNVDGD 539
            :|..:.|..|.:.:...|               |.:.|..:|..           ..|...|:|.
Zfish   518 LTKPSVNLHKPLGYTMSSPDFQQQYRTSASTPLCTSCGRQMLKG-----------VPSVEVVEGH 571

  Fly   540 ATATAATALSSTVGGGIGGIGGSIKMRASATDIETNALNGARDAIVASNNGNNGNNGNNGNNEYS 604
              .|.|..:..|........||...:|..:.:.|:.. ....|......|..........:.|.|
Zfish   572 --HTTANEMQRTRSADGAEYGGENLIREESLEAESQE-ERTSDTAGEKVNSQPEEEEQTSSTEQS 633

  Fly   605 ILQLNNTIIQCHFNDDDFRALVKDLKRKVEYTERMNWLCLSKRPLGPPHRKSSLPKHQEVKRR-- 667
            .|...        .|::||.   ||                           .|.:|:|:..:
Zfish   634 SLDPE--------GDEEFRL---DL---------------------------MLVEHEELMEKIN 660

  Fly   668 -----FLEICDTTFSEEVRAALRLPAFDSYEWSDADVIHLMQTMFVELGFIEKFSIPVDTLREWL 727
                 ..|:.|.|..:..|.                :.::..|:|.:.|..|.|.|||.....:.
Zfish   661 TWNFQIFELMDLTGGKTGRI----------------LSYVAYTLFQDTGLFEIFKIPVREFMTYF 709

  Fly   728 YEVYKHYNEVPFHNFRHCFCVAQMMYAITRQ--------------------------------AN 760
            ..:...|.::|:||..|...|...::.:|.|                                .:
Zfish   710 CALENGYRDIPYHNRVHATDVLHAVWYLTTQPIPGFQQIHNEHVTGSDTDSDSGISPGRVAYATS 774

  Fly   761 LLSRLGD------------LECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHH 813
            ..|...|            ||.:.|.|:...||.||||..|.:.:......|:.|||.|.|||||
Zfish   775 KSSSFQDDSYGCLAWNVPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHH 839

  Fly   814 CSIAFRL-LEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFME-----ITPIFDY 872
            .:.|:.| |..||.|...|.....|...|..:|..|||||:.:|.:.|.:|..     .:|..|:
Zfish   840 AASAWSLFLSRPEFNFLCNLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNSKVNDVNSPGIDW 904

  Fly   873 SNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSK 937
            :|.....|:|.:.||:|||:..|:...:...|.:.::.||:.|...|.:.|||::||||......
Zfish   905 TNENDRLLVCQVCIKLADINGPAKDRSLHLKWTEGIVNEFYEQGDEEGTLGLPISPFMDRSAPQL 969

  Fly   938 PGSQVRFIGLVLLPL---FEALGELVP 961
            ...|..||..::.||   ::|.| |:|
Zfish   970 AKLQESFITHIVGPLCNSYDAAG-LLP 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	79/276 (29%)
pde3b	XP_691883.4	PDEase_I	721..995	CDD:278654	78/274 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010