Protein Alignment Pde9 and pde4bb

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_009296519.1
• Gene: pde4bb / 555599
• ZFINID: ZDB-GENE-070912-454
• Length: 707
• Species: Danio rerio
• Alignment Length: 644
• Identity: 159/644 - (24%)
• Similarity: 270/644 - (41%)
• Gaps: 169/644 - (26%)

  Fly   426 NNMSNPAATAAAT-----ATP------SVEQPATSGTTNIHLQ--PTS----LPDGSDNPRRRRA 473
            :|:|.|.:....|     .||      .||...:.|.:.:.||  |.|    .|..:.:.:||.:
Zfish    63 DNVSRPTSLGFITPPRIDITPVPPDSLEVENGPSIGCSPLDLQVSPASGLILHPSMASHSQRRES 127

  Fly   474 ------SD-------CSAVQAALQNQLHCITLKNNNCGKAM---PFHRGSCGAAGEHLLAANSIA 522
                  ||       .|...:.:..|||         |:.:   ||        .:.|.:..::.
Zfish   128 FLYRSDSDYDLSPKSTSRNSSLVGEQLH---------GEDLIVTPF--------AQVLASLRTVR 175

  Fly   523 NRATIILSKSC----------------SNVDGDATATAATALSSTVGGGIGGIGGSIKMRASATD 571
            |..:|:.:.||                :|:..::....|......:...:..: .:|:...|.:|
Zfish   176 NNFSILTNVSCPSSKRSPISSHGPVTKANLSDESYQKLALETMEELDWCLDQL-ETIQTYRSVSD 239

  Fly   572 IETN----ALNGARDAIVASNNGNNGNNGNNGNNEYSILQLNNTIIQCHFNDDDFRALVKDLKRK 632
            :.:|    .||  |:....|....:||.    .:|:    ::||.:              |.:.:
Zfish   240 MASNKFKRMLN--RELTHLSEMSRSGNQ----VSEF----ISNTFL--------------DKQNE 280

  Fly   633 VEYTERMNWLCLSKRPLGPPHRKSSLPKHQEVKRRFLEI-------------------CDT---- 674
            :|.            ||       |.||.:|.|:|..::                   |.|
Zfish   281 LEI------------PL-------STPKSRERKKRQQQLMTQISGVRKVTHGSGPSSSCSTTRFG 326

  Fly   675 --TFSEEVRAALRLPAFDSYEW-----SDADVIH------LMQTMFVELGFIEKFSIPVDTLREW 726
              |.||::   |.....|..:|     ..|:..|      :|..:|.|...::.|.|||||...:
Zfish   327 VKTDSEDM---LSKDLEDINKWGLNIFKVAEHSHHRPLACIMYAIFQERDLMKTFKIPVDTFVTY 388

  Fly   727 LYEVYKHYN-EVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNI 790
            :..:..||: :|.:||..|...|||..:.:.....|.:...|||.|..|.:...||:||||.:|.
Zfish   389 MMTLEDHYHADVAYHNSLHAADVAQSTHILLSTPALDAVFTDLEILAALFAAAIHDVDHPGVSNQ 453

  Fly   791 YQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMAR 855
            :.||..:||||.|||.|.|||||.::.|:||:...|::|:|.|:.....:|:.:|..:|||||::
Zfish   454 FLINTNSELALMYNDESVLENHHLAVGFKLLQGENCDLFQNLSKKERQTLRKMVIHMVLATDMSK 518

  Fly   856 HNEILTQFMEITP-----------IFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLL 909
            |..:|.....:..           :.:|::|..:   ...::..||:||..:|:|:.:.|.||::
Zfish   519 HMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQV---LRNMVHCADLSNPTKPLDLYKQWTDRIM 580

  Fly   910 QEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELV-PELTELI 967
            ||||.|...|:..|:.::|..|....|...|||.||..::.||:|...:|| |:..:::
Zfish   581 QEFFHQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQDIL 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	82/239 (34%)
pde4bb	XP_009296519.1	PDEase_I	402..643	CDD:278654	82/241 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820