DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and pde5ab

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	XP_005166620.1	Gene:	pde5ab / 553270	ZFINID:	ZDB-GENE-060824-4	Length:	868	Species:	Danio rerio

Alignment Length:	316	Identity:	101/316 - (31%)
Similarity:	156/316 - (49%)	Gaps:	23/316 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   662 QEVKRRFLEICDTTFSEEVRA-------------ALRLP--AFDSYEWSDADVIHLMQTMFVELG 711
            |||....|....:...||.||             :|||.  :|..::.:||:.......|||:|.
Zfish   517 QEVTLEVLSYHASAAEEETRALQVTAAATIPSAQSLRLMDYSFSDFDLTDAETTQATIRMFVDLK 581

  Fly   712 FIEKFSIPVDTLREWLYEVYKHYNE-VPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLV 775
            .::.|.|...:|.:|:..|.|:|.: |.:||:||.|..:|.|:|:.:...:.:.|.|||.|.|::
Zfish   582 LVQNFQIKYKSLCQWILSVKKNYRKNVVYHNWRHAFNTSQCMFAVLKSGRVQNNLSDLETLALMI 646

  Fly   776 SCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNI 840
            :.:.|||||.|.||.|...:...||..|.. |.:|:||......:|..|...|....|.|.:...
Zfish   647 ATLSHDLDHRGVNNSYIKRSDHPLAQLYCH-STMEHHHFDQCLMILNSPGNQILSGLSLDEYKAT 710

  Fly   841 REGIIRCILATDMARHNEILTQFMEI--TPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEP 903
            .:.|.:.|||||:|.:.:..|:|.|:  ...|::.:..|.:||..:|:...|||...:|..|.:.
Zfish   711 LKMIEKAILATDLAVYMKKRTEFFELAKNSQFEWEDDCHRDLLRSMLMTACDISAITKPWPVQKK 775

  Fly   904 WLDRLLQEFFAQSAAEKSEGLPVTP--FMDPDKVSK-PGSQVRFIGLVLLPLFEAL 956
            ..:.:..|||.|...|:.| |.:.|  .|:.:|..| |..||.||..:...|:|||
Zfish   776 IAELVATEFFEQGDKERRE-LNIEPIDLMNREKQDKIPSMQVSFIDAICTQLYEAL 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	75/223 (34%)
pde5ab	XP_005166620.1	GAF	163..323	CDD:214500
		GAF	346..511	CDD:214500
		PDEase_I	610..845	CDD:278654	75/223 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920