DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and Pde3a

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	NP_061249.1	Gene:	Pde3a / 54611	MGIID:	1860764	Length:	1141	Species:	Mus musculus

Alignment Length:	866	Identity:	178/866 - (20%)
Similarity:	302/866 - (34%)	Gaps:	278/866 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 QEILLRHSIFDPGKEHQRA--------------IVLAAATAAIAGPLAAIDC---VCGSSSISLE 263
            :|.|:.||.:|    |:|.              .|:..|...|...||....   ||    .||.
Mouse   316 REQLMGHSEWD----HKRGPRGSQSGTSITVDIAVMGEAHGLITDLLADPSLPPNVC----TSLR 372

  Fly   264 AVSSRSRSSELEDDHHEQDQVQEEQEQEQHQ--GDTEDNEEEQEHPSEKPERTDIEEEPPPAI-- 324
            |||: ..|::|......:.:|.......::.  .|:|:..|:.:....|..|..:    ||.:
Mouse   373 AVSN-LLSTQLTFQAIHKPRVNPTVTFSENYTCSDSEEGLEKDKQAISKRLRRSL----PPGLLR 432

  Fly   325 ----AVTTTTTAT---------VRRKSSSS----------------------STISGTATVSGSV 354
                ..||||:||         |||..|:|                      :|::.:.:.:.|.
Mouse   433 RVSSTWTTTTSATGLPTLEPAPVRRDRSASIKPHEAPSPSAVNPDSWNAPGLTTLTKSRSFTSSY 497

  Fly   355 SVSASASQSFCSNNINLLEELLIQFYEEQDHRSNLTVIRHHHHQQHQQHQQQQRITNNNNNNNNC 419
            :|||:                                       .|.:.::|.|
Mouse   498 AVSAA---------------------------------------NHVKAKKQNR----------- 512

  Fly   420 NSIQNNNNMSNPAATAAATATPSVEQPATSGTTNIHLQPTSLPDGSD-----NPRRRRASDCSAV 479
                 ...::..:...:.:::|....||:|..:|...|  ..|:..:     .|...||...:..
Mouse   513 -----PGGLAKISPVPSPSSSPPQGSPASSPVSNSASQ--QFPESPEVTIKRGPGSHRALTYTQS 570

  Fly   480 QAALQNQLHCITLKNNNCGKAMPFHRGSCGAAGEHLLAANSIANRATIILSKSCSNVDGDATATA 544
            ...|..|:...::..::||:  |:.:|                           :..||.:..:
Mouse   571 APDLSPQIPPPSVICSSCGR--PYSQG---------------------------NPADGPSERS- 605

  Fly   545 ATALSSTVGGGIGGIGGSIKMRASATDIETNALNGARDAIVASNNGNNGNNGNNGNNEYSILQLN 609
                            |...::.:.|| :|:.:....:.             ||.::...||| |
Mouse   606 ----------------GPAMLKPNRTD-DTSQVTSDYET-------------NNNSDSSDILQ-N 639

  Fly   610 NTIIQCHFNDDDFRALVKDLKRKVE----YTERMNWLCLSKRPLGPPHRKSSLPKHQEVKRRFLE 670
            ....:|.          ::.:||..    ||.: ..:.|.|..|.|.      |...:.....::
Mouse   640 EEEAECQ----------REPQRKASACGTYTSQ-TMIFLDKPILAPE------PLVMDNLDSIMD 687

  Fly   671 ICDTTFSEEVRAALRLPAFDSYEWSDADVIHLMQ----TMFVELGFIEKFSIPVDTLREWLYEVY 731
            ..:|         ...|.||..|........::.    .:|.::|..|.|.|||.....:.:.:.
Mouse   688 QLNT---------WNFPIFDLMENIGRKCGRILSQVSYRLFEDMGLFEAFKIPVREFMNYFHALE 743

  Fly   732 KHYNEVPFHNFRHCFCVAQMMYAITRQ--ANLLSRLGD--------------------------- 767
            ..|.::|:||..|...|...::.:|.|  ..|.|.:||
Mouse   744 IGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLPSVIGDHGSASDSDSDSGFTHGHMGYVFSKMYH 808

  Fly   768 ---------------LECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIA 817
                           ||.:.|.|:...||.||||..|.:.:......|:.|||.|.|||||.:.|
Mouse   809 VPDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAA 873

  Fly   818 FRL-LEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQF---MEITPIFDYSNRAHI 878
            :.| :..||.|...|.....|.:.|..:|..|||||:.:|.:.:.:|   :......|::|....
Mouse   874 WNLFMSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDDVGIDWTNENDR 938

  Fly   879 NLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVR 943
            .|:|.:.||:|||:..|:..::...|.:.:..||:.|...|.|.|||::||||.........|..
Mouse   939 LLVCQMCIKLADINGPAKCKELHLRWTEGIASEFYEQGDEEASLGLPISPFMDRSAPQLANLQES 1003

  Fly   944 FIGLVLLPL---FEALGELVP 961
            ||..::.||   :::.| |:|
Mouse  1004 FISHIVGPLCHSYDSAG-LMP 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	78/274 (28%)
Pde3a	NP_061249.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..483		11/49 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..654		33/237 (14%)
		PDEase_I	751..1012	CDD:278654	73/260 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1060		178/866 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1120..1141
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010