DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde9 and PDE6B

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	XP_011511775.1	Gene:	PDE6B / 5158	HGNCID:	8786	Length:	941	Species:	Homo sapiens

Alignment Length:	329	Identity:	93/329 - (28%)
Similarity:	156/329 - (47%)	Gaps:	52/329 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   672 CDTTFSEEVRAALR--LP---AFDSYEW-------SDADVIHLMQTMFVELGFIEKFSIPVDTLR 724
            ||   .:|:...|:  ||   .||.||:       ::.|::.....|:.|||.:.||.||.:.|.
Human   553 CD---EDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLV 614

  Fly   725 EWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNN 789
            .:|:.:.|.|..:.:||:||.|.|||.|:.:.....|.|...|||...::.:.:|||:||.|.||
Human   615 RFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNN 679

  Fly   790 IYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMA 854
            :||:.::..|| :.:..|.||.||......||.....||::|.:|....::...:...|:|||:|
Human   680 LYQMKSQNPLA-KLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLA 743

  Fly   855 RHNEILTQFMEITPIFDYS-----NRAHINLLCM----------ILIKVADISNEARPMDVAEPW 904
            .:.:....|.:|.   |.|     .::.:..|.:          :::...|:|...:|.:|....
Human   744 LYFKKRAMFQKIV---DESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKV 805

  Fly   905 LDRLLQEFFAQSAAEKS--EGLPVTPFMDPDKVSK-PGSQVRFIGLV--------------LLPL 952
            ...:..||:.|...|::  :..|: |.||.:|.:: |..||.||..|              :||:
Human   806 ALLVAAEFWEQGDLERTVLDQQPI-PMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPM 869

  Fly   953 FEAL 956
            |:.|
Human   870 FDRL 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	70/250 (28%)
PDE6B	XP_011511775.1	GAF	144..303	CDD:214500
		GAF	325..512	CDD:214500
		PDEase_I	629..874	CDD:278654	70/250 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820