Protein Alignment Pde9 and PDE1B

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_011536758.1
• Gene: PDE1B / 5153
• HGNCID: 8775
• Length: 537
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 128/507 - (25%)
• Similarity: 199/507 - (39%)
• Gaps: 115/507 - (22%)

  Fly   603 YSILQLNNTIIQCHFNDDDFRALVKDLKRKVEYT------------------------------- 636
            |.:.||.|..|.           :::||:.:|||
Human    42 YMVKQLENGEIN-----------IEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVP 95

  Fly   637 -ERMNWLC--LSKRPLGPPHRKSSLPKHQEVK-------------RRFLEICDTTFSEEVRAALR 685
             |..:||.  .:::......|....||.:.:.             ||.......|:|..|...|:
Human    96 SEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLK 160

  Fly   686 ---LPAFDSYEWSDADVIHLMQTMFVEL----GFIEKFSIPVDTLREWL------YEVYKHYNEV 737
               |..||.:..:.|...|.::|:..||    ..|.:|.||...|..:|      |..||:
Human   161 NLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKN---- 221

  Fly   738 PFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALR 802
            |:||..|...|.|.::....:..::..|.::|.|.::.:...||.:|.|..|.:.|..::|.|:.
Human   222 PYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIV 286

  Fly   803 YNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEIT 867
            |||.|.|||||.|..|||::..|.|||.|.::|.|..:|..:|..:|||||:.|   ..|...:.
Human   287 YNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCH---FQQVKTMK 348

  Fly   868 PIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDP 932
            .......|........:|:..||||:..:...|...|...|::|||.|...|...|||.:|..|.
Human   349 TALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDR 413

  Fly   933 DKVSKPGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEYYRRLNDAQTKTRKS------ 991
            .......||:.||..::.|.|..|    .::.|..:.|  :|.|      |:::|.:.|
Human   414 TSTLVAQSQIGFIDFIVEPTFSVL----TDVAEKSVQP--LADE------DSKSKNQPSFQWRQP 466

  Fly   992 -----VADSNTSATS---------DSNSGTIDSNAAMVSTPGGASDKLSLDK 1029
                 |.|.|....|         ..|.......||     .|.::::|:|:
Human   467 SLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAA-----SGITNQMSIDE 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	72/227 (32%)
PDE1B	XP_011536758.1	PDEase_I_N	82..138	CDD:285672	6/55 (11%)
		PDEase_I	223..450	CDD:278654	73/235 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920