DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde9 and PDE9A

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	NP_002597.1	Gene:	PDE9A / 5152	HGNCID:	8795	Length:	593	Species:	Homo sapiens

Alignment Length:	394	Identity:	187/394 - (47%)
Similarity:	245/394 - (62%)	Gaps:	25/394 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   628 DLKRKVE----YTERMNWLCL-----SKRPLGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRAA 683
            |:|:..|    .:.|.|..|.     :.:.|.|.....:.||:             ..|.|...|
Human   204 DIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKY-------------LLSPETIEA 255

  Fly   684 LRLPAFDSYEWSDADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCV 748
            ||.|.||.:.|...:::..::.|:.:||.:..|||...|||.||:.|:.:|...|||||||||||
Human   256 LRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 320

  Fly   749 AQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHH 813
            |||||::....:|..:....:.|||:.:.||||||||||||.||||||||||:||||||||||||
Human   321 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHH 385

  Fly   814 CSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITPIFDYSNRAHI 878
            |::||::|..||||||.|...|.|..||:|:|..|||||||||.||:..|.|....|||||..|:
Human   386 CAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHM 450

  Fly   879 NLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVR 943
            .||.|||||..|||||.|||:|||||:|.||:|:|.||..||||||||.||||.|||:|..:|:.
Human   451 TLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 515

  Fly   944 FIGLVLLPLFEALGELVPELTELIIIPV---RIALEYYRRLNDAQTKTRKSVADSNTSATSDSNS 1005
            ||..||:|:||.:.:|.|.:.|:::.|:   |...|..:|::||..:.:|......:.||..|..
Human   516 FIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRE 580

  Fly  1006 GTID 1009
            .:.|
Human   581 RSRD 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	143/227 (63%)
PDE9A	NP_002597.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..141
		PDEase_I	311..539	CDD:278654	143/227 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..593		5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	302	1.000	Domainoid score	I1408
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0004612
OrthoInspector	1	1.000	-	-		oto89712
orthoMCL	1	0.900	-	-		OOG6_103870
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	1	1.000	-	-		X3819
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.750