Protein Alignment Pde9 and PDE8A

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_002596.1
• Gene: PDE8A / 5151
• HGNCID: 8793
• Length: 829
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 143/558 - (25%)
• Similarity: 230/558 - (41%)
• Gaps: 141/558 - (25%)

  Fly   467 NPRRRRASDCSAVQAALQNQLHCITLKNNNCGKAMPFHRGSCGAAGEHLLAANSIANRATIILSK 531
            |.:..:.|:|      :|:..|    .:|..||.....:||        |...::|:|||.:.|:
Human   329 NNKAEKISEC------VQSDTH----TDNQTGKHKDRRKGS--------LDVKAVASRATEVSSQ 375

  Fly   532 SCSNVDGDATATAATALSSTVGGGIGGIGGSIKMRASATDIE-TNALN----------------G 579
            .       ..::.|...|.|:...|..:...|.....::.:. |.||:                |
Human   376 R-------RHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEILRTTELYSPQFG 433

  Fly   580 ARDAIVASNN--GNNGNNG--NNGNNEYSILQLNNTIIQCH----FNDDDFRALVKDLKRKVEYT 636
            |:|....:|:  |...::|  ....|||.:...|..::..:    .:.||....:.......||.
Human   434 AKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYW 498

  Fly   637 ERMNWLCLSKRPLGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRAALRLPAFDSYEWSDA---- 697
            :                                                   ||.:|...|
Human   499 D---------------------------------------------------FDIFELEAATHNR 512

  Fly   698 DVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEV-PFHNFRHCFCVAQMMYAITRQANL 761
            .:|:|...||...|..|.......|||.||..:..:|:.. |:||..|.   |.:::|   .|..
Human   513 PLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHS---ADVLHA---TAYF 571

  Fly   762 LSR------LGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRL 820
            ||:      |..::.:..|::...||:||||..|.:..||.:|||:.|||.:.||:||.::||:|
Human   572 LSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQL 636

  Fly   821 LE-HPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEI--TPIFDY-------SNR 875
            .. ..:||||||..|:.:..:|:|||..:|||:|.:|.|.:.:|:..  .|:...       .|:
Human   637 TTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQ 701

  Fly   876 AHIN----------LLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVT-PF 929
            ..||          |:..:|||.||:||..||:.....|..|:.:|:|:|:..||.:||||. |.
Human   702 EVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPV 766

  Fly   930 MDPDKVSKPGSQVRFIGLVLLPLFEALGELV--PELTE 965
            .|.:..|.|.||:.||...:..:|:|....|  |:|.:
Human   767 FDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPDLMQ 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	88/256 (34%)
PDE8A	NP_002596.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..46
		OmpR	82..>159	CDD:223816
		REC	83..>170	CDD:302758
		PAS_9	226..324	CDD:290162
		PAS	230..324	CDD:238075
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..360		6/30 (20%)
		Involved in RAF1-binding. /evidence=ECO:0000269|PubMed:23509299	454..461		1/6 (17%)
		PDEase_I	555..807	CDD:278654	88/256 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950