Protein Alignment Pde9 and PDE7A

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_001229247.1
• Gene: PDE7A / 5150
• HGNCID: 8791
• Length: 482
• Species: Homo sapiens
• Alignment Length: 350
• Identity: 97/350 - (27%)
• Similarity: 160/350 - (45%)
• Gaps: 23/350 - (6%)

  Fly   669 LEICDTTFSEEVRAALRLPA---FDSYEW----SDADVIHLMQTMFVELGFIEKFSIPVDTLREW 726
            |.|.|..::.:.:..|....   ||.:.:    :...::.|...:|...|.||.|.:.:..||.:
Human   133 LNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRF 197

  Fly   727 LYEVYKHY-NEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNI 790
            |..:.:.| ::.|:||..|...|.|.|:...::..|.:.:...:.|:.|::...|||||||.|..
Human   198 LVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQP 262

  Fly   791 YQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMAR 855
            :.|.....||..|.:.|.|||||...|..||.  |..:|.:...::...:...|...|||||::|
Human   263 FLIKTNHYLATLYKNTSVLENHHWRSAVGLLR--ESGLFSHLPLESRQQMETQIGALILATDISR 325

  Fly   856 HNEILTQFMEITPIFD--YSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAA 918
            .||.|:.|.......|  ..:..|.:|:..:.:|.|||.|..|..::::.|.:::.:|||.|...
Human   326 QNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDI 390

  Fly   919 EKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELV-PELTELIIIPVRIALEYYRRLN 982
            ||...|.|:|..|....|....|:.|:..::.|||....... ..|::.::..|        .||
Human   391 EKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHV--------GLN 447

  Fly   983 DAQTK--TRKSVADSNTSATSDSNS 1005
            .|..|  .|:..:..:|.|..:.||
Human   448 KASWKGLQREQSSSEDTDAAFELNS 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	70/230 (30%)
PDE7A	NP_001229247.1	PDEase_I	211..444	CDD:395177	70/234 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820