Protein Alignment Pde9 and PDE6A

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_000431.2
• Gene: PDE6A / 5145
• HGNCID: 8785
• Length: 860
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 118/456 - (25%)
• Similarity: 193/456 - (42%)
• Gaps: 88/456 - (19%)

  Fly   636 TERMNWLCLSKRPLGPPHRKSSLPKHQEVKRRFLEI------CDTTFSEEVRAALR--------- 685
            |:.:.|..|:      |....|:.|.:..|..|.:|      ||   :||::..|:
Human   424 TQFLGWSVLN------PDTYESMNKLENRKDIFQDIVKYHVKCD---NEEIQKILKTREVYGKEP 479

  Fly   686 ---------------LPAFDSYE-----WSDADVIHLMQT-----MFVELGFIEKFSIPVDTLRE 725
                           ||..|.||     :||..:..|...     |:.||..::||.||.:.|..
Human   480 WECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVR 544

  Fly   726 WLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNI 790
            ::|.:.|.|.::.:||:||.|.|.|.|:::.....|.....|||.|.::.:..|||:||.|.||:
Human   545 FMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNL 609

  Fly   791 YQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMAR 855
            ||:.::..|| :.:..|.||.||......||.....|||:|.:|....:....:...|:|||:|.
Human   610 YQMKSQNPLA-KLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLAL 673

  Fly   856 HNEILTQFMEITPIFDYS---------------NRAHINLLCMILIKVADISNEARPMDVAEPWL 905
            :.:..|.|.:|.   |.|               .:....::..:::...|:|...:|.:|.....
Human   674 YFKKRTMFQKIV---DQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVA 735

  Fly   906 DRLLQEFFAQSAAEKS--EGLPVTPFMDPDKVSK-PGSQVRFIGLVLLPLFEALGELVPELTELI 967
            ..:..||:.|...|::  :..|: |.||.:|..: |..||.||..|...:::.......|:|.::
Human   736 LLVAAEFWEQGDLERTVLQQNPI-PMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPML 799

  Fly   968 --IIPVR-----IALEYYRRLNDAQTKTRKSVADSNTSATSDSNSGTIDSNAAMVSTPGGASDKL 1025
              |...|     :|.||     ||:.|.::.......||.|.:.......|    .:||||:...
Human   800 DGITNNRKEWKALADEY-----DAKMKVQEEKKQKQQSAKSAAAGNQPGGN----PSPGGATTSK 855

  Fly  1026 S 1026
            |
Human   856 S 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	68/245 (28%)
PDE6A	NP_000431.2	GAF	75..232	CDD:214500
		GAF	254..441	CDD:214500	5/22 (23%)
		PDEase_I	558..802	CDD:365964	68/248 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	821..860		10/40 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820