DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pde9 and PDE4B

DIOPT Version :10

Sequence 1:NP_727644.3 Gene:Pde9 / 32233 FlyBaseID:FBgn0259171 Length:1623 Species:Drosophila melanogaster
Sequence 2:NP_002591.2 Gene:PDE4B / 5142 HGNCID:8781 Length:736 Species:Homo sapiens


Alignment Length:448 Identity:117/448 - (26%)
Similarity:196/448 - (43%) Gaps:91/448 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   702 LMQTMFVELGFIEKFSIPVDTLREWLYEVYKHY-NEVPFHNFRHCFCVAQMMYAITRQANLLSRL 765
            :|..:|.|...::.|.|..||...::..:..|| ::|.:||..|...|||..:.:.....|.:..
Human   367 IMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVF 431

  Fly   766 GDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFK 830
            .|||.|..:.:...||:||||.:|.:.||..:||||.|||.|.|||||.::.|:||:...|:||.
Human   432 TDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFM 496

  Fly   831 NFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITP-----------IFDYSNRAHINLLCMI 884
            |.::.....:|:.:|..:|||||::|..:|.....:..           :.:|::|..:   ...
Human   497 NLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQV---LRN 558

  Fly   885 LIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVL 949
            ::..||:||..:.:::...|.||:::|||.|...|:..|:.::|..|....|...|||.||..::
Human   559 MVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIV 623

  Fly   950 LPLFEALGELV-PELTELIIIPVRIALEYYRRLNDAQTKTRKSVADSNTSATSDSNSGTIDSNAA 1013
            .||:|...:|| |:..:::           ..|.|.:...:..:..|.:....:.|.   |....
Human   624 HPLWETWADLVQPDAQDIL-----------DTLEDNRNWYQSMIPQSPSPPLDEQNR---DCQGL 674

  Fly  1014 MVSTPGGASDKLSLDKGQGNSQGSGGGGGGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISV 1078
            |..    ...:|:||  :.:|:|                              |:  :.|.|.|.
Human   675 MEK----FQFELTLD--EEDSEG------------------------------PE--KEGEGHSY 701

  Fly  1079 KSRRSIPSQKSASRTSVDEPGGMASELHDLPEGSESGDSETATEVDVAEKTSKFKVDT 1136
            .|        |.....|.:|              |:.||...|::|:|.: .|..|||
Human   702 FS--------STKTLCVIDP--------------ENRDSLGETDIDIATE-DKSPVDT 736

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde9NP_727644.3 PDEase_I 739..967 CDD:459723 78/239 (33%)
PDE4BNP_002591.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..78
PDE4_UCR 166..281 CDD:465648
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 189..209
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..301
PDEase_I 405..645 CDD:459723 78/253 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 685..736 19/107 (18%)
Blue background indicates that the domain is not in the aligned region.

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