Protein Alignment Pde9 and PDE4A

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_001104777.1
• Gene: PDE4A / 5141
• HGNCID: 8780
• Length: 886
• Species: Homo sapiens
• Alignment Length: 279
• Identity: 95/279 - (34%)
• Similarity: 154/279 - (55%)
• Gaps: 16/279 - (5%)

  Fly   702 LMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYN-EVPFHNFRHCFCVAQMMYAITRQANLLSRL 765
            :|..:|.|...::||.|||||:..::..:..||: :|.:||..|...|.|..:.:.....|.:..
Human   394 IMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVF 458

  Fly   766 GDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFK 830
            .|||.|..|.:...||:||||.:|.:.||..:||||.|||.|.|||||.::.|:||:...|:||:
Human   459 TDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQ 523

  Fly   831 NFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITP-----------IFDYSNRAHINLLCMI 884
            |.|:....::|:.:|..:|||||::|..:|.....:..           :.:||:|..:   ...
Human   524 NLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQV---LRN 585

  Fly   885 LIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVL 949
            ::..||:||..:|:::...|.||::.|||.|...|:..|:.::|..|....|...|||.||..::
Human   586 MVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIV 650

  Fly   950 LPLFEALGELV-PELTELI 967
            .||:|...:|| |:..|::
Human   651 HPLWETWADLVHPDAQEIL 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	82/239 (34%)
PDE4A	NP_001104777.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..128
		PDE4_UCR	178..293	CDD:465648
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..331
		PDEase_I	432..672	CDD:459723	82/241 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..705
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	866..886