Protein Alignment Pde9 and PDE3B

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_001350499.1
• Gene: PDE3B / 5140
• HGNCID: 8779
• Length: 1190
• Species: Homo sapiens
• Alignment Length: 819
• Identity: 162/819 - (19%)
• Similarity: 279/819 - (34%)
• Gaps: 257/819 - (31%)

  Fly   443 VEQPATSGTTNIH--LQPTSLPDGSDNPRRRRASDCSAVQAALQNQLHCITLKNNNCGK------ 499
            :|.||..|...::  |...|||    .|:.||:|..|.:....|:     :..:.|.||
Human   491 IEDPAEKGDRKLNKGLNRNSLP----TPQLRRSSGTSGLLPVEQS-----SRWDRNNGKRPHQEF 546

  Fly   500 ------------------AMPFHRGSCGAAGEHL---------------------LAANSIANRA 525
                              .:|..|.|..:...|:                     ::..|:.||
Human   547 GISSQGCYLNGPFNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNR- 610

  Fly   526 TIILSKSCSNVDGDATATAATALSSTVGGGIGGIGGSIKMRASATDIETNALNGARDAIV----- 585
                    |.::...||......|..:...:|....:........:.::|..|.....::
Human   611 --------SPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVST 667

  Fly   586 ASNNGNNGNNGNNGNNEYSILQLNNTIIQCHFNDDDFRALVKDLKRKVE-------YTERMNWLC 643
            :.::|.:..:|.:|..|..            |:.:.|:.:....:.:.|       :.|...||.
Human   668 SESDGTDCCSGKSGEEENI------------FSKESFKLMETQQEEETEKKDSRKLFQEGDKWLT 720

  Fly   644 LSKRPLGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRAALRLPAFDSY----EWSDADVIHLMQ 704
            ...:    ..:::::  .|||....:.:.:.....|..:....|.|:..    |.|...:..:|.
Human   721 EEAQ----SEQQTNI--EQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMY 779

  Fly   705 TMFVELGFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQ----------- 758
            |:|.:.|.:|.|.||......:...:...|.::|:||..|...|...::.:|.:
Human   780 TLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNG 844

  Fly   759 --------------------------AN-------LLSRLGDLECLILLVSCICHDLDHPGYNNI 790
                                      :|       |.|.:..||.:.|.|:...||.||||..|.
Human   845 CGTGNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNA 909

  Fly   791 YQINARTELALRYNDISPLENHHCSIAFRL-LEHPECNIFKNFSRDTFNNIREGIIRCILATDMA 854
            :.:......|:.|||.|.|||||.:.|:.| |..||.|...:.....|...|..:|..|||||:.
Human   910 FLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLK 974

  Fly   855 RHNEILTQF-MEITPI----FDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFA 914
            :|.:.|.:| .:...:    .::||.....|:|.:.||:|||:..|:..|:...|.:.::.||:.
Human   975 KHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYE 1039

  Fly   915 QSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPL---FEALGELVPELTELIIIPVRIALE 976
            |...|.:.|||::||||.........|..||..::.||   ::|.|.|..:..|
Human  1040 QGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLE----------- 1093

  Fly   977 YYRRLNDAQTKTRKSVADSNTSATSDSNSGTIDSNAAMVSTPGGASDKLSLDKGQGNSQGSGGGG 1041
                          :..|::|.:..|.:...:|:.                |:...|
Human  1094 --------------AEEDNDTESGDDEDGEELDTE----------------DEEMEN-------- 1120

  Fly  1042 GGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISVKSRRSIPSQKSASRTSVDEPGGMASELH 1106
                                  :::|:.||.      ||||.|..|.                :|
Human  1121 ----------------------NLNPKPPRR------KSRRRIFCQL----------------MH 1141

  Fly  1107 DLPEGSESGDSETATEVDVAEKTSKFKVD-----TEGSS 1140
            .|.|..:...       ::.|:..|.|.|     .|.||
Human  1142 HLTENHKIWK-------EIVEEEEKCKADGNKLQVENSS 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	78/280 (28%)
PDE3B	NP_001350499.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		Interaction with RAPGEF3. /evidence=ECO:0000269|PubMed:21393242	1..25
		COG5373	<102..>282	CDD:444140
		CynX	<190..263	CDD:442057
		PDEase_I	814..1088	CDD:459723	76/273 (28%)