DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and PDE3B

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	NP_001350499.1	Gene:	PDE3B / 5140	HGNCID:	8779	Length:	1190	Species:	Homo sapiens

Alignment Length:	819	Identity:	162/819 - (19%)
Similarity:	279/819 - (34%)	Gaps:	257/819 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 VEQPATSGTTNIH--LQPTSLPDGSDNPRRRRASDCSAVQAALQNQLHCITLKNNNCGK------ 499
            :|.||..|...::  |...|||    .|:.||:|..|.:....|:     :..:.|.||
Human   491 IEDPAEKGDRKLNKGLNRNSLP----TPQLRRSSGTSGLLPVEQS-----SRWDRNNGKRPHQEF 546

  Fly   500 ------------------AMPFHRGSCGAAGEHL---------------------LAANSIANRA 525
                              .:|..|.|..:...|:                     ::..|:.||
Human   547 GISSQGCYLNGPFNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNR- 610

  Fly   526 TIILSKSCSNVDGDATATAATALSSTVGGGIGGIGGSIKMRASATDIETNALNGARDAIV----- 585
                    |.::...||......|..:...:|....:........:.::|..|.....::
Human   611 --------SPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVST 667

  Fly   586 ASNNGNNGNNGNNGNNEYSILQLNNTIIQCHFNDDDFRALVKDLKRKVE-------YTERMNWLC 643
            :.::|.:..:|.:|..|..            |:.:.|:.:....:.:.|       :.|...||.
Human   668 SESDGTDCCSGKSGEEENI------------FSKESFKLMETQQEEETEKKDSRKLFQEGDKWLT 720

  Fly   644 LSKRPLGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRAALRLPAFDSY----EWSDADVIHLMQ 704
            ...:    ..:::::  .|||....:.:.:.....|..:....|.|:..    |.|...:..:|.
Human   721 EEAQ----SEQQTNI--EQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMY 779

  Fly   705 TMFVELGFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQ----------- 758
            |:|.:.|.:|.|.||......:...:...|.::|:||..|...|...::.:|.:
Human   780 TLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNG 844

  Fly   759 --------------------------AN-------LLSRLGDLECLILLVSCICHDLDHPGYNNI 790
                                      :|       |.|.:..||.:.|.|:...||.||||..|.
Human   845 CGTGNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNA 909

  Fly   791 YQINARTELALRYNDISPLENHHCSIAFRL-LEHPECNIFKNFSRDTFNNIREGIIRCILATDMA 854
            :.:......|:.|||.|.|||||.:.|:.| |..||.|...:.....|...|..:|..|||||:.
Human   910 FLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLK 974

  Fly   855 RHNEILTQF-MEITPI----FDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFA 914
            :|.:.|.:| .:...:    .::||.....|:|.:.||:|||:..|:..|:...|.:.::.||:.
Human   975 KHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYE 1039

  Fly   915 QSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPL---FEALGELVPELTELIIIPVRIALE 976
            |...|.:.|||::||||.........|..||..::.||   ::|.|.|..:..|
Human  1040 QGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLE----------- 1093

  Fly   977 YYRRLNDAQTKTRKSVADSNTSATSDSNSGTIDSNAAMVSTPGGASDKLSLDKGQGNSQGSGGGG 1041
                          :..|::|.:..|.:...:|:.                |:...|
Human  1094 --------------AEEDNDTESGDDEDGEELDTE----------------DEEMEN-------- 1120

  Fly  1042 GGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISVKSRRSIPSQKSASRTSVDEPGGMASELH 1106
                                  :::|:.||.      ||||.|..|.                :|
Human  1121 ----------------------NLNPKPPRR------KSRRRIFCQL----------------MH 1141

  Fly  1107 DLPEGSESGDSETATEVDVAEKTSKFKVD-----TEGSS 1140
            .|.|..:...       ::.|:..|.|.|     .|.||
Human  1142 HLTENHKIWK-------EIVEEEEKCKADGNKLQVENSS 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	78/280 (28%)
PDE3B	NP_001350499.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Interaction with RAPGEF3. /evidence=ECO:0000269\|PubMed:21393242	1..25
		DUF1109	136..>282	CDD:310850
		PDEase_I	814..1088	CDD:306695	76/273 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920