Protein Alignment Pde9 and PDE2A

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_002590.1
• Gene: PDE2A / 5138
• HGNCID: 8777
• Length: 941
• Species: Homo sapiens
• Alignment Length: 645
• Identity: 151/645 - (23%)
• Similarity: 250/645 - (38%)
• Gaps: 159/645 - (24%)

  Fly   370 NLLEELLIQFYEEQDHRSNLTVIRHHHHQ---------QHQQHQQ-------------------- 405
            |.||..|  |.:|.:|     ||:|..|.         ..|:.|:
Human   351 NKLEGDL--FTDEDEH-----VIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLD 408

  Fly   406 ------QQRITNNNNNNNN--CN-SIQNNNNMSNPAATAAATATPSVE--QPATSGTTNIHLQPT 459
                  |:.||...|.:|.  |: .:.:.|.:.............|.|  .||..|... |:..|
Human   409 DVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAG-HVATT 472

  Fly   460 ----SLPDGSDNPRRRRASDCSAVQAALQNQLHCITLKNNNCGKAMPFHRGSCGAAGEHLLAANS 520
                ::||...:|...|..|.|.  ......:.|..:||.|                :.::....
Human   473 GQILNIPDAYAHPLFYRGVDDST--GFRTRNILCFPIKNEN----------------QEVIGVAE 519

  Fly   521 IANRATIILSKSCSNVDGDATATAATALSSTVGGGIGGIGGSIKMRASATDIETNALNGARDAIV 585
            :.|:   |.....|..|.|    .|||.|...|..|            |..:....:|.|
Human   520 LVNK---INGPWFSKFDED----LATAFSIYCGISI------------AHSLLYKKVNEA----- 560

  Fly   586 ASNNGNNGNNGNNGNNEYSILQLNNTIIQCHF--NDDDFRALVKDLKRKVEYTERMNWLCLSKRP 648
                            :|. ..|.|.::..|.  :||::..|:.|..:.|...: .|:...:..|
Human   561 ----------------QYR-SHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAID-SNFASFTYTP 607

  Fly   649 LGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRAALRLPAFDSYEWSDADVIHLMQTMFVELGFI 713
                   .|||:.           ||:.:                     ::.::|    ::.||
Human   608 -------RSLPED-----------DTSMA---------------------ILSMLQ----DMNFI 629

  Fly   714 EKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCI 778
            ..:.|...||..:...|.|.|.:.|:||:.|.|.|:...|.:.:...|.:.|.|:|...|.:||:
Human   630 NNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCM 694

  Fly   779 CHDLDHPGYNNIYQINARTELALRY-NDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIRE 842
            ||||||.|.||.:|:.:::.||..| ::.|.:|.||.:.|..:|....||||.:|||..:..:.:
Human   695 CHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLD 759

  Fly   843 GIIRCILATDMARHNEILTQFMEITPI-FDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLD 906
            .:...|||||:|.|..|.....::..: :|.:|:.|..||..:|:...|:|::.:.........:
Human   760 LMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE 824

  Fly   907 RLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTEL 966
            .:.:|||:|...||:.|......||.:|...|..|:.|:..:.:|:::.|.:|.|:..||
Human   825 LIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAEL 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	74/230 (32%)
PDE2A	NP_002590.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..42
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..221
		GAF	241..387	CDD:214500	12/42 (29%)
		GAF	409..558	CDD:214500	36/186 (19%)
		PDEase_I	655..885	CDD:306695	74/230 (32%)
		Substrate binding	656..660		2/3 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820