DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and PDE11A

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	NP_058649.3	Gene:	PDE11A / 50940	HGNCID:	8773	Length:	933	Species:	Homo sapiens

Alignment Length:	977	Identity:	201/977 - (20%)
Similarity:	353/977 - (36%)	Gaps:	280/977 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 TTAQEGTSPSGGSSSSGNA-------------VLL-------QRSSNNLQQQQQQQQQQQQHLQL 170
            :|.:.|:|..||:..:|:|             |.|       .|...|||::..|::
Human    64 STCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE-------- 120

  Fly   171 QLQQADERLLRKIGYIASRVRCLSKYYGD---FRLVNPYSARRQRRQLQEILLRHSIFDPGKEHQ 232
                     ||| .:..|:...:::.|.:   .|...|.|:.|:|    .:|.:.|...|...|.
Human   121 ---------LRK-SFARSKAIHVNRTYDEQVTSRAQEPLSSVRRR----ALLRKASSLPPTTAHI 171

  Fly   233 RAIVLAAATAAIAGPLAAIDCVC-----GSSSISLEAVSSRSRSSEL---------------EDD 277
            .:.:|.:.......|..|||..|     ......||.|...|...:|               :.|
Human   172 LSALLESRVNLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDAD 236

  Fly   278 HHEQDQVQEEQEQEQ---------HQG-------DTEDNEEEQ------------EH------PS 308
            ......|:.....::         |.|       .||::.|.|            ||      |.
Human   237 RCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPD 301

  Fly   309 EKPERTDIEEEPPPAIAVTTTTTATVRRKSSSSSTISGTATVSGSVSVSASASQS---------- 363
            ...:|. ..:|........|.:...:..:||....| |.|.....:...|..::.
Human   302 AYQDRR-FNDEIDKLTGYKTKSLLCMPIRSSDGEII-GVAQAINKIPEGAPFTEDDEKVMQMYLP 364

  Fly   364 FCSNNINLLEELLIQFYEEQDHRSNLTVIRHHHHQQHQQHQQQQRITNNNNNNNNCN--SIQNNN 426
            ||...|:..:.......|.:..|:.|.|:.....:|....:..::|.:.......|.  |:....
Human   365 FCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLE 429

  Fly   427 NMSNP---------------AATAAATATPSVEQPATS------------GTTNIHLQPTSLPDG 464
            ::.:|               :|.|..:...|:|:.:.|            .:|.:   |.::.|.
Human   430 DIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGL---PVNISDA 491

  Fly   465 SDNPRRRRASDCSAVQAA---LQNQLHCITLKNNNCGKAMPFHRGSCGAAGEHLLAANSIANRAT 526
            ..:||    .|..|.|.:   :::.| |:.:.|:|                ..::....:.||
Human   492 YQDPR----FDAEADQISGFHIRSVL-CVPIWNSN----------------HQIIGVAQVLNR-- 533

  Fly   527 IILSKSCSNVDG----DATATAATALSSTVGGGIGGIGGSIKMRASATDIETNALNGARDAIVAS 587
                     :||    ||......|.....|.||
Human   534 ---------LDGKPFDDADQRLFEAFVIFCGLGI------------------------------- 558

  Fly   588 NNGNNGNNGNNGNNEYSILQLNNTIIQCHFNDDDFRALVKDLKRKVEYTERMNWLCLSKRPLGPP 652
                                 ||||:        :..:.|...::....:.:::.....:.....
Human   559 ---------------------NNTIM--------YDQVKKSWAKQSVALDVLSYHATCSKAEVDK 594

  Fly   653 HRKSSLPKHQEVKRRFLEICDTTFSE-------EVRAALRLPAFDSYEWSDADVIHLMQTMFVEL 710
            .:.:::|...|     |.|.|..|.:       .:.||||                    ||:||
Human   595 FKAANIPLVSE-----LAIDDIHFDDFSLDVDAMITAALR--------------------MFMEL 634

  Fly   711 GFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLV 775
            |.::||.|..:||..||..|.|:|..|.:||:||.|.|.|:|:|:...|.....|.::|.|.::|
Human   635 GMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIV 699

  Fly   776 SCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNI 840
            .|:||||||.|.||.:|..:.:.||..|...:.||:||.:.|..:|:....|||.|.|...::::
Human   700 GCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDL 764

  Fly   841 REGIIRCILATDMARHNEILTQFMEITP--IFDYSNRAHINLLCMILIKVADISNEARPMDVAEP 903
            .:.:.:.|||||:..:.|..|:|.|:..  .:|::.:.|.::...:|:...|:....:|.:::..
Human   765 MQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQ 829

  Fly   904 WLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSK---PGSQVRFIGLVLLPLFEALGELVPELTE 965
            ..:.:..|||.|...|:.| |.:||....|:..|   |..|:.:|..:.:||::||.::..:|..
Human   830 VAELVTSEFFEQGDRERLE-LKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP 893

  Fly   966 LI 967
            ::
Human   894 ML 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	72/232 (31%)
PDE11A	NP_058649.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..125		17/78 (22%)
		GAF	217..380	CDD:214500	24/164 (15%)
		GAF	402..568	CDD:214500	35/260 (13%)
		PDEase_I	663..898	CDD:278654	72/234 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154177
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750