DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and Pde6

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster

Alignment Length:	1315	Identity:	275/1315 - (20%)
Similarity:	450/1315 - (34%)	Gaps:	365/1315 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SSAAAATSTAATAAETAAAAAATTTSSSDEETLETLTIITTTITDSDIHATTTTTTVIASGTATT 81
            ||.|...::....:.|::::||||::||.:           .:|:.            |:.||.:
  Fly     5 SSPAGGAASPVEMSTTSSSSAATTSASSSK-----------PLTNG------------ANKTAIS 46

  Fly    82 AAAAATTATLATLATLASNSDIEDSSPVESEDSEECEYIEIDCQTTAQEGTSPSGG------SSS 140
            .||...|                                         .|..|..|      |||
  Fly    47 TAAGGVT-----------------------------------------PGAVPGPGSGAIPASSS 70

  Fly   141 SGNAVLLQ---RSSNN--------------------LQQQQQQQQQQQQHLQLQLQQADERLLRK 182
            |||.|.|:   |.|||                    .....|...|.|..:|.|..|.|.  |.|
  Fly    71 SGNQVKLEHHHRQSNNNRPAVTNRSSETKLMTPTGSSSSPSQSPSQTQASIQTQTSQQDR--LAK 133

  Fly   183 IGYIASR--VRCLSKYYGDFRLVNPYSARR--QRRQLQEILLR-HSIFDPGKEHQRAIVLAAATA 242
            ....||:  |..:::.:.:    .|.:..:  ..|...|.|.| ....:..|.|:|..|   .:.
  Fly   134 ASTTASQQDVDEVARLFEE----KPEAFEKWLTERAPPEALSRLQEFIENRKPHKRPSV---TSD 191

  Fly   243 AIAGPLAAIDCVCGSSSISLEAVSSRSRSSELEDDHHEQDQVQEEQEQEQHQGDTEDNEEEQEHP 307
            .....:||...|...|..||    |.|.:|.|             .|..:|..|.::.|...|..
  Fly   192 LFQQWMAASPTVQQKSPRSL----SNSSASSL-------------PECRRHLMDLDEGELFMELI 239

  Fly   308 SEKPERTDIE----------------EEPPPAIAVTTTTTA-------TVRRKSSSSSTISGTAT 349
            .:.....||:                :.....:|..|.|..       .|.:|::....::..:.
  Fly   240 RDVANELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDAVTRASA 304

  Fly   350 ----VSGSVSVSASASQSFCSNNINLLEELLIQFYEEQDHRSNLTVIRHHHHQQHQQHQQQQRIT 410
                :...:.::...:|:  ...||:.|..       :|.|.|..:               ...|
  Fly   305 EEIIIPFGIGIAGMVAQT--KQMINIKEAY-------KDARFNCEI---------------DLKT 345

  Fly   411 NNNNNNNNCNSIQNNN----------NMSNPAATAAATATPSVEQPATSGTTNIHLQPTSLPDGS 465
            ....|...|..|.|..          |.:|..............:..|  ...|.:|...|.:.|
  Fly   346 GYKTNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLT--FCGIGIQNAQLFEMS 408

  Fly   466 DNPRRRRASDCSAVQAAL--QNQLHCIT----------LKNNNCGKAMPFHRGSCGA-------- 510
            ....||.....:..::..  ||.|.|:.          ||...|...: .....|.|
  Fly   409 VQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFL-VDLDCCEASHLEKIIE 472

  Fly   511 -----AGEHLLAANS-----IANRATIIL----SKSCSNVDGDATATAATALSSTVGGGIGGIGG 561
                 |...:.:|:|     :.||.|::.    ....:||...:.:..:::..:.:...:...|.
  Fly   473 KPNQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQ 537

  Fly   562 SI-------------KMRASATDIETNA------LNGARDAIVASNNGNNGNNGNNGNNEYSI-- 605
            ::             ::||......|.|      :|..:..|..:...|..|.....:::.||
  Fly   538 TVNICDVIEWVRDHNQIRAEDEIDSTQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFE 602

  Fly   606 -------LQLNNTIIQCHFNDDDFRALVKDLKRKVEYTERMNWLCLSKRPLGPPHRKSSLPKHQE 663
                   |.::||  |.:.|.....|     |:||...      |||........:...|.:...
  Fly   603 AFAIFCGLGIHNT--QMYENACKLMA-----KQKVALE------CLSYHATASQDQTEKLTQDVI 654

  Fly   664 VKRRFLEICDTTFSEEVRAALRLPAFDSYEWSDADVIHLMQTMFVELGFIEKFSIPVDTLREWLY 728
            .:.....:...||::             :|..|.|....:..||::...:.:|.||.|.|..|:.
  Fly   655 AEAESYNLYSFTFTD-------------FELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVL 706

  Fly   729 EVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQI 793
            .|.|:|..|.:||:||...|||.|:|:.:...:...:.|||.|.|||:|:||||||.|.||.:|.
  Fly   707 SVRKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQT 771

  Fly   794 NARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNE 858
            ...:.||:.|. .|.:|:||......:|.....|||:..|.:.:.::.:.:...||:||:|.:.:
  Fly   772 KTESPLAILYT-TSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFK 835

  Fly   859 ILTQFMEITP--IFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKS 921
            ....|:|:..  .||:......:|||.:::...|:|..|:|.:|.......:..|||.|...||.
  Fly   836 KRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKL 900

  Fly   922 EGLPVTPFMDPDKVSK---PGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEYYRRLND 983
            : |...|....|:..|   |..||.||.::.|||:..|.:..|.:|.|    ....||..|...|
  Fly   901 Q-LNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPL----YEGTLENRRNWQD 960

  Fly   984 AQTKTRKSVA--DSNT--------SATSDSNSGTIDSNAAMVSTPGGASDKLSLDKGQGNSQGSG 1038
            ...|....:.  |.:|        :|.:|.....|:....            :|:..|.:..||
  Fly   961 LAEKVEMGLTWIDHDTIDKPVEEFAACADEEIKDIEFTVT------------TLNCNQQSQHGS- 1012

  Fly  1039 GGGGGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISVKSRRSIPSQKSASRTSVDEPGGMAS 1103
                                   ..|.:|:..||||.:|:|...::   ..|.|:.      ::.
  Fly  1013 -----------------------EDSHTPEHQRSGSRLSMKKTGAL---GKAVRSK------LSK 1045

  Fly  1104 ELHDLPEGSESG------DSETATEVDVAEKTSKFKVDTEGSSNRSKSSHSTSRKSSREKRPSMI 1162
            .|::..:||:..      :|..:.::|....||..:....||..|..:|.||
  Fly  1046 TLYNSMDGSKPKTSLKLLESHVSEDMDDKSPTSPSQPQASGSMGRMSASSST------------- 1097

  Fly  1163 GELCSSGGGQRIRNS 1177
                ||.|||.:..|
  Fly  1098 ----SSAGGQMVDKS 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	77/232 (33%)
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	25/184 (14%)
		GAF	431..619	CDD:214500	30/190 (16%)
		PDEase_I	717..950	CDD:278654	78/238 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I1950
eggNOG	1	0.900	-	-		E1_KOG3689
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46491
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.920