Protein Alignment Pde9 and pde10a

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_017214212.1
• Gene: pde10a / 394077
• ZFINID: ZDB-GENE-040426-1115
• Length: 852
• Species: Danio rerio
• Alignment Length: 923
• Identity: 195/923 - (21%)
• Similarity: 329/923 - (35%)
• Gaps: 234/923 - (25%)

  Fly   247 PLAAIDC------VCGSSSISLEAVSSRSRSSELEDDH----HEQDQVQEEQEQEQHQG------ 295
            |.....|      :|.|..:|:...:|..||....:.|    |.:..:.::::.....|
Zfish     5 PCEGFSCQHPASFMCLSRQLSVYRYNSNIRSEPRTNRHQRTRHYRPAMSKKRKTPDDGGGGGELA 69

  Fly   296 DTED-------NEEEQEHPSEKPERTDIEEEPPPAIAVTTTTTATV----RRKSSSSSTISGTAT 349
            ||||       :|:.:.:.|..|:..|       ...:.:.::.||    :||||         |
Zfish    70 DTEDSLQQGLTDEKVKAYLSLHPQMLD-------EFVLESVSSETVDRWLKRKSS---------T 118

  Fly   350 VSGSVSVSASASQSFCSNNINLLEELLIQFYEEQDHRSNLTVIRHHHHQQHQQHQQQQRITNNNN 414
            .....|.:...|:.:...|:..:      .||...:                   .:||:....:
Zfish   119 QPADDSSAKEVSRQYQDTNMQSV------VYELNSY-------------------MEQRLDTGGD 158

  Fly   415 NN----NNCNSIQN---------------NNNMSNPAATAAATATPSV--EQPATSGTT-NIHLQ 457
            |.    ..||.|:.               ||::.....|.|....|.:  ..|.|.||| ..|:.
Zfish   159 NKLLLYELCNIIKTATKADGFALYFLGECNNSLCLFTPTGAKEGLPGLIPSGPITFGTTIAAHVA 223

  Fly   458 PT-------------SLPDGS--DNPRRRRASDCSAVQAALQNQLHCITLKNNNCGKAMPFHRGS 507
            .|             ..|.|:  |:..|..:..|..:..|:.:.:..:.| :.:.|:. ||:...
Zfish   224 KTRKTLLVEDIMGDERFPHGTGQDSGIRVHSVLCLPILTAIGDLIAILEL-HRHLGRE-PFNLSH 286

  Fly   508 CGAAGEHLLAANSIANRATII--LSKSCSNVDGDATATAATALSSTVGGGIGGIGGSIKMRASAT 570
            ...|..:|..|:...::..:.  |:|. :.::......:.|...:.|  .|..:...|.:.|.
Zfish   287 QEVATANLAWASVAIHQVQVCRGLAKQ-TELNDFLLDVSKTYFDNIV--AIDSLLEHIMIYAK-- 346

  Fly   571 DIETNALNGARDAIVASNNGNNG--------NNGNNGNNEY----------------------SI 605
                |.:|..|.|:...::.|..        ...|.|...:                      .:
Zfish   347 ----NLVNADRCALFQVDHNNKELYSDLFDIGEENEGKPVFRKTKEIRFSIEKGIAGQVARTGEV 407

  Fly   606 LQLNNTIIQCHFNDDDFRALVKDLKRKVE----YTERMNWLCLSKRPL----------------- 649
            |.:.:......||            |:|:    ||.| |.||:   |:
Zfish   408 LNIPDAYADPRFN------------REVDLYTGYTTR-NILCM---PIVSRGTVIGVVQMVNKLG 456

  Fly   650 GPPHRKSS----------------------LPKHQEV-------KRRFLEICDTTFSEEVRAALR 685
            |....|:.                      ..:|.|.       |..:..||.   |||.:...:
Zfish   457 GSAFTKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICT---SEEWKTLTQ 518

  Fly   686 LPAFDSYEWSDADVIHLMQTMFVELG---FI-------EKFSIPVDTLREWLYEVYKHYNEVPFH 740
            | ...|..:.:.::.|.....|.||.   |:       .|.|..::.|..:...|.|:|..||:|
Zfish   519 L-TLPSAIYKEIELFHFDIAPFEELWPAIFVYMVHNSCGKTSFELEKLCRFTMSVRKNYRRVPYH 582

  Fly   741 NFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYND 805
            |::|...||..||||.::...:  ..:||...||::|:||||||.||:|.|.......||..|:
Zfish   583 NWKHAVTVAHCMYAILQKTTGI--FTELERKGLLIACLCHDLDHRGYSNSYLQKFDHPLAALYS- 644

  Fly   806 ISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEI--TP 868
            .|.:|.||.|....:|:....|||.|.:...:..:.|.|.:.|:|||:|.:.....|..|:  |.
Zfish   645 TSTMEQHHFSQTVSILQLEGHNIFSNLTSGEYEQVLEIIRKAIIATDLALYFGNRKQLAELLSTG 709

  Fly   869 IFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPD 933
            ..|.:||||.:.:..:::...|:.:..:...|.....:.:..||:|:....|..|:.....||.|
Zfish   710 ALDLNNRAHRDRVIGLMMTACDLCSVTKLWPVTRLTANDIYAEFWAEGDEMKKIGMQPISMMDRD 774

  Fly   934 KVSK-PGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEYYRRLNDAQTKTRKSVADSNT 997
            |..: |..||.|...|.:|.:..|.||.|....|:........::.|.:.........|..::..
Zfish   775 KKDEVPQGQVGFYNAVAIPCYTTLSELFPPSVPLLEACRENLSQWERIVQGEDVSAWSSTEEAEV 839

  Fly   998 SATSDSNSGTIDS 1010
            |.||||....:|:
Zfish   840 SETSDSGPVKVDN 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	73/230 (32%)
pde10a	XP_017214212.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920