DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and Pde11

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster

Alignment Length:	1563	Identity:	332/1563 - (21%)
Similarity:	522/1563 - (33%)	Gaps:	540/1563 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 RSSNNLQQQQQQQQQQQQHLQLQLQQADERLLRKIGYIASRVRCLSKYYGDFRLVNPYSARRQRR 213
            :||...||||||||||||..|.|.||....        :.:::..|:       :.|.:.....|
  Fly    20 KSSKQQQQQQQQQQQQQQQHQQQQQQTPSH--------SPQIQHHSE-------IIPATTGLHLR 69

  Fly   214 QLQEILLRHSIFDP-----------------GKEHQRAIVLAAATAAIAGPLAAIDCV------C 255
            .::|.......|.|                 ..||  ::::|...|.:..|||....:      .
  Fly    70 SIEEPATTPLQFQPTGRMNTEQGGTGYGGYGSSEH--SLLIATRHAGVPLPLAQHQPLPAHYQPL 132

  Fly   256 GSSSISLEAVSSRSRSS------ELEDDHHEQDQVQEE-QEQEQHQGDTEDNEEEQEHPSEKPER 313
            ..|..:..:.|:.|.||      .......:|.|||:. |.|.||....:.|..:...|.: ||.
  Fly   133 NHSGAAPPSSSNGSSSSGGGVQTSATPQQQQQYQVQQPYQYQYQHHYHHQANSPQHHRPYD-PEH 196

  Fly   314 TDIE-----------------------------------------EEPPPAIAVTTTT------T 331
            ..:|                                         ..|..|...|:::      |
  Fly   197 ARMEAWLDENQEFVQDYFIRKATRQTVDAWLVSHATSAGNDVVSSTSPTHANGQTSSSRGGSGAT 261

  Fly   332 ATVRRKSSSS-----------STISGTATV--------SGSVSVSASASQSFCSNNINLLEELLI 377
            ..||:.|:..           :||.||.|.        :|||..|       |||..|:...:..
  Fly   262 TPVRKISAHEFERGGLLKPIVNTIDGTPTFLSIGPPMDNGSVGGS-------CSNLQNVGGVVAG 319

  Fly   378 QF-YEEQDHRSNLTVIRHHHHQQHQQ--------------------------------------- 402
            |: |..|.|..|..   |.||.||..
  Fly   320 QYQYNHQQHHHNHA---HLHHSQHSHYQAGGAVGSSSLGSTGGASGAGGAPSLGGSGGAGNGHQY 381

  Fly   403 -----HQQQQRITNNNNN------------NNNCNS----------IQNNNNMSN---------- 430
                 ||:.||::.|...            .:.||.          :||.:.:.|
  Fly   382 PYYHCHQRPQRLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQ 446

  Fly   431 ---------------------PAATA----------AATATPSVEQPATSGTTNIHLQPTSLPDG 464
                                 |.:|.          .|..|......|.||      :|.::||.
  Fly   447 GRCNGPDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESG------EPVNIPDA 505

  Fly   465 SDNPR-----------RRRASDCSAVQAALQNQL---HCITLKNNNC-----GKAMPFHRGSCGA 510
            ..:.|           |.:|..|..::.:..:.:   ..|...|..|     .|....:...||.
  Fly   506 YQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGI 570

  Fly   511 AGEHL------------------LAANSIANRATI------ILSK-----SCSNVD--------- 537
            ...:.                  ||......::||      ||:.     .|..|.
  Fly   571 GLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADK 635

  Fly   538 -----------GDATATAATALSSTVGGGIG---GIGGSIKMRASATDIET----NALNGAR-DA 583
                       .|.:...||:.:|.......   ||.|.:     ||..||    ||....| ||
  Fly   636 GSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHV-----ATTGETVNVPNAYEDDRFDA 695

  Fly   584 IVASNNGNNGNN------GNNGNNEYSILQLNNTIIQCHF--NDDDF------------------ 622
            .|..|:.....:      .|:......::||.|...:..|  ||::|
  Fly   696 SVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMY 760

  Fly   623 -RALVKDLKRKVEYTERMNWLCLSKRPLGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRAALRL 686
             :|:|...|:.|. .|.:::           |..:::.:...::|                 ||:
  Fly   761 EKAIVAMAKQSVT-LEVLSY-----------HASATMDEAHRLRR-----------------LRV 796

  Fly   687 PA----------FDSYEWSDADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEVPFHN 741
            |:          ||...:.|.|.:.....||::|.|:|:|.|..:.|..||..|.|:|..|.:||
  Fly   797 PSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHN 861

  Fly   742 FRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDI 806
            :||.|.|||||:||..........|::|||.|::.|:||||||.|.||.:||.|.:.||..|: .
  Fly   862 WRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-T 925

  Fly   807 SPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFME-ITPIF 870
            |.:|:||......:|..|...|..|.|.|.:..:...:...||:||:|.:.:....|:| ::...
  Fly   926 STMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPT 990

  Fly   871 DY----SNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTP--F 929
            .|    ..||   ||..:.:.|.|:|...:|.::.:...|.:..|||.|...||.| |.:||  .
  Fly   991 SYWVAEEPRA---LLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDI 1051

  Fly   930 MDPDKVSK-PGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEYYRRLND-AQTKTRKS- 991
            |:.:|..: |..||.||..:.||::||...|..:| |.::..||....::..|.| .:|||.:.
  Fly  1052 MNREKEDELPMMQVNFIDSICLPIYEAFATLSDKL-EPLVEGVRDNRGHWIDLADVVKTKTSQDQ 1115

  Fly   992 -----------VADSNTSATSDSNSGTIDSNAAMVSTPGGASDKLSLDKGQGNSQGSGGGGGGGG 1045
                       :::.:..|.||.:....::..| |.:|   |:|.|::
  Fly  1116 EPEEEQQQQNVISNGDCKAMSDDDVAASEAEVA-VDSP---SEKASVN----------------- 1159

  Fly  1046 GGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISVKSRRSIPSQKSASRTSVDEPGGMASELHDLPE 1110
                        |||.|.:.|          :...:.::.|..::::.|.|:        :|:..
  Fly  1160 ------------GSNVANNSS----------NTNKKIAVASHPTSTQPSDDD--------NDVDA 1194

  Fly  1111 GSESGDSETATEVDVAEKTSKFKVDTEGSSNRSKSSHSTSRKSSREKRPSMIGELCSSG------ 1169
            .::..|.:.|.|       :....:.:.:|.||.|:.|:|..||....|...||..|:.
  Fly  1195 DADDVDEQAAEE-------NGHDAEVDEASCRSNSTCSSSTASSCLSTPPPTGEDDSTPVSPLKT 1252

  Fly  1170 -GGQRIRNSYGNIHGYHSNRCHFGNNRAVSLDQYSSAGNNRRLSD--GLPQVISDSNVFYGRHNR 1231
             ..:.:..:...:....||:......|..|.|...|....|:.|.  |..::..||....|.|..
  Fly  1253 LQAKLVAANLNALQRQTSNQAQTQKQRCKSCDHSRSGLQVRKTSSLRGAQELDLDSKTRNGTHAA 1317

  Fly  1232 SSTETTVAVGNPQDTN-------------------ANTNHPVGCQLKELLARTEADSDGEGDGNG 1277
            ....|.|...:....|                   .::.|.:|.        ..|...|.|
  Fly  1318 LCKSTPVINNHSHHHNHSHSHNHNHHHHHHHHSHHNHSQHGIGI--------GSASIGGSG---- 1370

  Fly  1278 REDKKIPLVIPSMPQLATSSN---------GNISPTLVVTEQILP-SNGSTRSSASSGRGGSGVP 1332
                   |:..:.|.||..|:         ||:..        || :||     ....:.|.|:|
  Fly  1371 -------LISLTTPLLAMDSDRIPKIVGKIGNLDG--------LPFANG-----IGGPQNGHGLP 1415

  Fly  1333 GGS 1335
            .||
  Fly  1416 FGS 1418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	84/235 (36%)
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	23/167 (14%)
		GAF	611..762	CDD:214500	30/155 (19%)
		PDEase_I	859..1094	CDD:278654	84/240 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45459133
Domainoid	1	1.000	82	1.000	Domainoid score	I1950
eggNOG	1	0.900	-	-		E1_KOG3689
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46491
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850