Protein Alignment Pde9 and Pde1c

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Alignment Length: 1264
• Identity: 269/1264 - (21%)
• Similarity: 446/1264 - (35%)
• Gaps: 382/1264 - (30%)

  Fly     3 QDSGCSSSSSRRGSSSAAAATSTAATAAETAAAAAATTTSSSDEETLETLTIITTTITDSDIHAT 67
            :|.......|..|:|.||.::|::...|.:.||:.:...:|.
  Fly   165 RDEASGGPGSSGGTSGAATSSSSSGGGAASGAASGSVGPASG----------------------- 206

  Fly    68 TTTTTVIASGTA---TTAAAAATTATLATLATLASNSDIEDS-------SPVESEDSEECEYIEI 122
            |.|.|..|||.|   :|.|..|.:.|::.|:...||:.|...       :.:...:|.  .:.:.
  Fly   207 TATGTGSASGGAGGVSTPAQEAASPTVSELSGSGSNATINGQVARHGSLTIIRRTNSR--NFTQF 269

  Fly   123 DCQ-----TTAQEGTSP------------------------SGGSSSSGNAVLLQRSSNNLQQQQ 158
            |.|     :||...|:|                        |.||:|:|::    ||||    |.
  Fly   270 DGQLASPSSTACSSTAPGIGFAQTPLSEPLAERLSFRASGGSNGSASAGDS----RSSN----QG 326

  Fly   159 QQQQQQQQHLQLQLQQADERLLRKIGYIASRVRCLSKYYGDFRLVNPYSARRQRRQLQEILLRHS 223
            ...........:::|.:..   ....|:|..::..|               ....|.:.::.|.|
  Fly   327 PSNSGPAASAAVKMQPSSP---NATNYLADNIQISS---------------ANLSQTEMVVGRDS 373

  Fly   224 IFDPGKEHQRAIVLAAATAAIAGPLAAIDCVCGSSSISLEAVSSRSRSSELEDDHHEQDQVQEEQ 288
                          |..||     :.:|:...|:|.:
  Fly   374 --------------ADYTA-----MHSINVGVGNSFL---------------------------- 391

  Fly   289 EQEQHQGDTEDNEEEQEHPSEKPERTDI------EEEPPPAIAVTTTTTATVRRKS--------- 338
                 :||| |..:|..|..|.|.....      .|..||.........|..|.:|
  Fly   392 -----RGDT-DIPQESGHSFETPSNMSFTAGQWDTESLPPVDTPDALNKAAGRIRSLLRRMDHET 450

  Fly   339 ----SSSSTISGTATVSGSVSVSASASQSFCSNNINLLEELLIQFYEEQDHRSNLTVIRHHHHQQ 399
                .....:...|.|..:|.:  ..|:..|:.|.                 .||...||.|.:.
  Fly   451 VAYEDMQRNLHYAARVLEAVFI--DESREGCNGNC-----------------KNLNCSRHSHGRD 496

  Fly   400 HQQHQQQQRITNNNNNNNNCNSIQNNNNMSNPAATAAATATPSVE-----QPATSGTT---NIHL 456
            .||.       :|||:|.:| |:|.    ::|.. |.|..||..:     :..|.|.:   ..|.
  Fly   497 DQQQ-------DNNNSNRSC-SLQE----ASPGG-AGAGVTPGADNQDSIESRTKGVSQAPQTHS 548

  Fly   457 QPTSLPDGSDNPRRRRASDCSAVQAALQNQLHCITLKNNNCGKAMPFHRGSCGAAGEHLLAANSI 521
            .||..|  |:......|.....:|.||:      |::.:
  Fly   549 GPTGPP--SNTSSETIAQPAPKLQPALE------TVRES-------------------------- 579

  Fly   522 ANRATIILSKSCSNVDGD---------ATATAATALSSTVGGGIGGIGGSIKMRASATDIETNAL 577
                  ::.:|.|...||         :|.|:.|..||           |.....||...|:.|
  Fly   580 ------VMEESPSKDPGDKGPPPPASTSTLTSQTTTSS-----------SATAEPSAKAAESQA- 626

  Fly   578 NGARDAIVASNNGNNGNNGNNGN-------------NEYSILQLNNTIIQCHFNDDDFRALVKDL 629
                        |:.|::|:..|             .....:..|.|.:.   ::||   .:.::
  Fly   627 ------------GSAGSSGSCSNPAAVHRQRRLRTPTWARSMSTNKTRLA---DEDD---ELSEV 673

  Fly   630 KRKVEYTERMNWLCLS-KRPLGPPHRKS-SLPKHQEVK-------------RRFLEICDTTFSEE 679
            :......|...||..: .|.:....||| ..||.:.|.             ||......|.|..:
  Fly   674 QPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRRVSSSALTAFPPD 738

  Fly   680 VRAALRLP---AFDSYEWSDAD----VIHLMQTMFVELGFIEKFSIPVDTLREWLYEV---YKHY 734
            |...|:..   .||.:..::|.    |.::...:|...|.|.||.|....|..:|:.|   |..|
  Fly   739 VVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRY 803

  Fly   735 NEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTEL 799
            .. |:||..|...|.|.::.......|::.|.|||....|::.:.||.:|.|..|.:.:.:.:|.
  Fly   804 RN-PYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSET 867

  Fly   800 ALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFM 864
            ||.|||.:.|||||.|.:||||...|.||..:.||:.|..:|..:|..:|.|||..|.:.:....
  Fly   868 ALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMR 932

  Fly   865 EITPIFDYSNRAHIN---LLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPV 926
            ::..:    ..|.|:   :|.::| ...|||:.|:...|...|...||:|||.|...||..|||.
  Fly   933 QLLTL----QEATIDKQKVLSLVL-HCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPF 992

  Fly   927 TPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEYYRRLNDAQTKTRKS 991
            :|..|.:......||:.||..::.|   ::| ::.::.|||:.|:       ..:|.::..|
  Fly   993 SPLCDRNNTLVAESQICFIDFIVEP---SMG-VMSDMLELILAPI-------APMNKSKPAT--- 1043

  Fly   992 VADSNTSATSDSNSGTIDSNAAMVSTPGGASDKLSLDKGQGNSQGSGGGGGGGGGGGAGGGTGSG 1056
            :.:..|:|.|.:||..:..|:.:  ||       |:||.:.:..             ....|.:.
  Fly  1044 LVEHETTANSTTNSAIVIPNSGI--TP-------SMDKPRDHRT-------------EAKTTAAE 1086

  Fly  1057 C--GSNAAGSVSPQ--MPRSGSGISVKSRRSIPSQ------KSASRTSVDEPGGMASELHDLPEG 1111
            |  ..:..|:.:.:  :|:......|:::|....|      ..|..|:.:|....|:
  Fly  1087 CLARKSVTGTTASKFNIPKPWLTCLVENKRIWKEQAVKDAEARALATAAEEAAAAAA-------- 1143

  Fly  1112 SESGDSETATEVDVAEKTSKFKVDTEGSS 1140
            :|:.:|:..||....|::.......:|::
  Fly  1144 AEAEESKPETETADGEQSEPAAEPADGAA 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	75/230 (33%)
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	12/58 (21%)
		PDEase_I	807..1026	CDD:278654	74/227 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I1950
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46491
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020