Protein Alignment Pde9 and Pde8b

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_008758892.1
• Gene: Pde8b / 309962
• RGDID: 735041
• Length: 885
• Species: Rattus norvegicus
• Alignment Length: 918
• Identity: 190/918 - (20%)
• Similarity: 327/918 - (35%)
• Gaps: 271/918 - (29%)

  Fly   296 DTEDNEEEQEHPSEKPE--------RTDIEEEPPPAIAVTTTTTATVRRK-----SSSSSTISGT 347
            |..::..:....|:.|.        :||..:..||:.|........|||.     |.||:..||.
  Rat    21 DESNSPRQTSSVSQGPTAPLHGLFVQTDAADAMPPSRAAGPPGAVRVRRSRAELGSGSSTGSSGP 85

  Fly   348 A--TVSG-----SVSVSASASQSFCS-NNINLLE-------------ELLIQFYEEQD------- 384
            |  |..|     ..|..|....|:.| ..::..|             ::|:.|.:|..
  Rat    86 AATTCRGRRRHCCSSAEAETQTSYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWW 150

  Fly   385 ------HRSNLT---------VIRHHHHQQHQQHQQQQRITNNNNNNNNCNSIQNNNNMSNPAAT 434
                  :|.|:.         .:..||......|:|    |.|.:....|.||:..|...:....
  Rat   151 ACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQ----TRNFDAEAVCRSIRATNPSEHTVIL 211

  Fly   435 AAATATPSVEQPAT------SGTTNIHLQPTSL---------PDGSDNPRRRRASDCSAVQAALQ 484
            |..:......:.|:      :|.....::.:|:         .:..:...:.:...|::|..||.
  Rat   212 AVVSQASDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALD 276

  Fly   485 NQLHC------------ITLKNNNCGKAMPFHRGSCGAAGEHLL-AANSIANRATII-------- 528
               ||            |...|....:.|.:|:|.  ..|:.|. ...|..|||.::
  Rat   277 ---HCHEAIEITSDDHVIQYVNPAFERMMGYHKGE--LLGKELADLPKSDKNRADLLDTINTCIK 336

  Fly   529 ----------------------------------------LSKSCSNVD------------GDAT 541
                                                    |.|.|...|            ||.:
  Rat   337 KGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDSSKQIHRIHRDSGDNS 401

  Fly   542 ATAATALS--------------STVGGGIGGIGG----------SIKMRASATDIETNALNGARD 582
            .|...:..              |:.|.....:..          |:.:.|..|.: .|.:|.|::
  Rat   402 QTEPHSFRHKSRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKV-INIINAAQE 465

  Fly   583 AIVASNNGNNGNNGNNGNNEYSILQLNNTII-----------QCHFNDDD------FRALVKDLK 630
                             |:..::.:..:.::           |....|:|      ...|:.|..
  Rat   466 -----------------NSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGL 513

  Fly   631 RKV---EYTERMNWLCLSKRPLGPPHRKSSLP-KHQEVKRRFLEICDTTFSEEVRAALRLPAFDS 691
            |::   ||....|        :...|...|:| ...:|.....::.|...|.:         |:.
  Rat   514 RRLSGNEYVFTKN--------VHHSHSHLSMPITINDVPPSIAQLLDNEESWD---------FNI 561

  Fly   692 YEWS----DADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEV-PFHNFRHCFCVAQM 751
            :|..    ...:::|...:|...|..|..:....|||.||..:..:|:.. .:||..|...|...
  Rat   562 FELEAITHKRPLVYLGLKVFSRFGVCEFLNCTETTLRAWLQVIEANYHSSNAYHNSTHAADVLHA 626

  Fly   752 MYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSI 816
            ......:..:...|..|:.:..|::...||:||||..|.:..||.:|||:.|||.:.||:||.::
  Rat   627 TAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTAL 691

  Fly   817 AFRL-LEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFM---------------- 864
            ||:| ::..:||||||..|:.:..:|:.||..:|||:|.:|.|.:.:|:
  Rat   692 AFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPLAAESEGSDC 756

  Fly   865 EITPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVT-P 928
            |..|.........| |:..::||.||::|..||:|:...|..|:.:|:|||:..||.:||||. |
  Rat   757 ECNPTGKNFPENQI-LIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMP 820

  Fly   929 FMDPDKVSKPGSQVRFIGLVLLPLFEA------LGELVPELTELIIIPVRIALEYYRRLNDAQTK 987
            ..|.:..|.|.||:.||...:..:|:|      |..|:..|.:        ..::::.|:|.:.|
  Rat   821 VFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLAD--------NYKHWKTLDDLKCK 877

  Fly   988 TRKSVADS 995
            :.:..::|
  Rat   878 SLRLPSNS 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	83/251 (33%)
Pde8b	XP_008758892.1	PDE8	1..47	CDD:285793	3/25 (12%)
		PAS_9	279..377	CDD:290162	11/99 (11%)
		PAS	284..376	CDD:238075	11/93 (12%)
		PDEase_I	614..861	CDD:278654	82/247 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920