DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and Pde8a

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	NP_942062.1	Gene:	Pde8a / 308776	RGDID:	735125	Length:	823	Species:	Rattus norvegicus

Alignment Length:	749	Identity:	177/749 - (23%)
Similarity:	289/749 - (38%)	Gaps:	189/749 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 QDHRSNLTVIRHHHHQQHQQHQQQQRITNNNNNNNNCNSIQNNNNMSNPAAT------------- 434
            ||...::.:|.|.:.:|......             |.||:::....|....
  Rat   115 QDKLHDIIIIDHRNPRQMDAEAM-------------CRSIRSSKLSENTVIVGVVRRVDKEEVSL 166

  Fly   435 ----AAATATPSVEQPATSGTTNIHLQPTSLPDGSDNPR-RRRASDCSAVQAALQNQLHC--ITL 492
                ||......:|.|......|..||   |..|....: :.||  |::|..||:.....  ||.
  Rat   167 MPFLAAGFTRRYIENPNVMACYNELLQ---LAFGEVRSQLKLRA--CNSVFTALEKSQEAIEITS 226

  Fly   493 KNNNCGKAMPFHRGSCG-AAGEHL---LAANSIANRATIILS--KSCSNVDGDATATAATALSST 551
            :::....|.|....:.| .:||.:   ||...|..:...:|.  .||..:|.:......|...:
  Rat   227 EDHIIQYANPAFETTMGYQSGELIGKELAQVPINEKKGDLLDAINSCVTIDKEWQGVYHTQKKN- 290

  Fly   552 VGGGIG---------GIGGSIKMRAS------------------ATDIETNALNG--------AR 581
             |..|.         |.||.|:...|                  .||.:|::..|        :.
  Rat   291 -GDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGSNKVETTTECVQTDSQTDSQAGKHKDRRKHSM 354

  Fly   582 DAIVASNNGNNGNN---------------------------GNNGNNEYSILQLNNTIIQC---- 615
            |....|:..:..:|                           ....|:..|:.:..|.::..
  Rat   355 DVKAVSSRTSEVSNQRRHSSLARIHSMMIEAPITKVINILSAAQENSPVSVTEALNHVLDILRTT 419

  Fly   616 -----HFN-DDDFRA------LVKDLKRKV---EYTERMNWLCLSKRPLGPPHRKSSLP-KHQEV 664
                 .|| :||..|      |:.|..|:.   |||       |:.:.|.|...:.::| ...::
  Rat   420 ELYSPQFNTEDDPHATDLVGGLMSDGLRRFSGNEYT-------LATKSLRPSSSQLAVPISLHDI 477

  Fly   665 KRRFLEICDTTFSEEVRAALRLPAFDSYEWSDA----DVIHLMQTMFVELGFIEKFSIPVDTLRE 725
            ..|..::.:.....:         ||.:|...|    .:|:|....|......|.......||:.
  Rat   478 PPRIAQVIENEEQWD---------FDIFELEAATQNRPLIYLGLKTFARFEICEFLQCSEATLKS 533

  Fly   726 WLYEVYKHYNEV-PFHNFRHCFCVAQMMYAITRQANLLSR------LGDLECLILLVSCICHDLD 783
            |...:..:|:.. |:||..|   .|.:::|   .|..|||      |..|:.:..|::...||:|
  Rat   534 WFQIIESNYHSSNPYHNSTH---AADVLHA---TAYFLSRNKLKDTLDRLDEVAALIAATIHDVD 592

  Fly   784 HPGYNNIYQINARTELALRYNDISPLENHHCSIAFRL-LEHPECNIFKNFSRDTFNNIREGIIRC 847
            |||..|.:..||..|||:.|||.:.||:||.::||:| ||:.:||||||..|:.:..:|:.||..
  Rat   593 HPGRTNSFLCNAGKELAVLYNDTAVLESHHAALAFQLTLENDKCNIFKNTDRNDYRTLRQSIIDM 657

  Fly   848 ILATDMARHNEILTQFMEI--TPIFDYSN------------RAHI------NLLCMILIKVADIS 892
            :|||:|.:|.|.:.:|:..  .|:....|            ||.:      .|:..::||.||:|
  Rat   658 VLATEMTKHFEHVNKFINSINKPLKAQKNEVQETGRSLEDIRAMVRTPESRTLIKRMMIKCADVS 722

  Fly   893 NEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVT-PFMDPDKVSKPGSQVRFIGLVLLPLFEAL 956
            |..||::....|..|:.:|:|:|:..||...|||. |..|.:..|.|.||:.||...:..:|:|.
  Rat   723 NPCRPLEHCIEWAARISEEYFSQTDEEKQLDLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAW 787

  Fly   957 GELV--PELTELIIIPVRIALEYYRRLNDAQTKT 988
            ...|  |.|..    .:....:|::.|::.:..|
  Rat   788 DAFVYLPNLMR----HLEDNFKYWKGLDEKELCT 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	89/257 (35%)
Pde8a	NP_942062.1	PDE8	1..44	CDD:285793
		PAS_9	220..318	CDD:290162	22/99 (22%)
		PAS	224..318	CDD:238075	22/95 (23%)
		PDEase_I	548..801	CDD:278654	89/262 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920