DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde9 and Pde6a

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	NP_001100856.1	Gene:	Pde6a / 307401	RGDID:	1306835	Length:	860	Species:	Rattus norvegicus

Alignment Length:	468	Identity:	118/468 - (25%)
Similarity:	198/468 - (42%)	Gaps:	94/468 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   619 DDDFRALVKDLKRKVEYTERMNWLCLSKRPLGPPHRKSSLPKHQEVKRRFLEI------CDTTFS 677
            ||....|::.|      |:.:.|..|:      |....|:.|.:..|..|.:|      ||   :
  Rat   413 DDMDETLMESL------TQFLGWSVLN------PDTYESMNKLENRKDIFQDIVKYHVKCD---N 462

  Fly   678 EEVRAALR------------------------LPAFDSYE-----WSDADVIHLMQT-----MFV 708
            ||::..|:                        ||..:.||     :||..:..|...     |:.
  Rat   463 EEIQKILKTREVYGKEPWECEEEELAEILQEELPDAEKYEINKFHFSDLPLTELELVKCGIQMYY 527

  Fly   709 ELGFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLIL 773
            ||..::||.||.:.|..::|.:.|.|..:.:||:||.|.|.|.|:::.....|.....|||.|.:
  Rat   528 ELRVVDKFHIPQEALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLMTGKLKRYFTDLEALAM 592

  Fly   774 LVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFN 838
            :.:..|||:||.|.||:||:.::..|| :.:..|.||.||......||.....|||:|.:|....
  Rat   593 VTAAFCHDIDHRGTNNLYQMKSQNPLA-KLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHE 656

  Fly   839 NIREGIIRCILATDMARHNEILTQFMEITPIFDYS---------------NRAHINLLCMILIKV 888
            :....:...|:|||:|.:.:..|.|.:|.   |.|               .:....::..:::..
  Rat   657 HAIHMMDIAIIATDLALYFKKRTMFQKIV---DQSKTYESTQEWTQYMMLEQTRKEIVMAMMMTA 718

  Fly   889 ADISNEARPMDVAEPWLDRLLQEFFAQSAAEKS--EGLPVTPFMDPDKVSK-PGSQVRFIGLVLL 950
            .|:|...:|.:|.......:..||:.|...|::  :..|: |.||.:|..: |..||.||..|..
  Rat   719 CDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPI-PMMDRNKADELPKLQVGFIDFVCT 782

  Fly   951 PLFEALGELVPELTELI--IIPVR-----IALEYYRRLNDAQTKTRKSVADSNTSATSDSNSGTI 1008
            .:::.......|:|.::  |...|     :|.||..|:...:.:.:|..| :..:|:.:...|.
  Rat   783 FVYKEFSRFHEEITPMLDGITNNRKEWKALADEYEARMKALEEEKQKQQA-AKQAASGNQPGGN- 845

  Fly  1009 DSNAAMVSTPGGA 1021
                   .:||||
  Rat   846 -------PSPGGA 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	68/245 (28%)
Pde6a	NP_001100856.1	GAF	80..232	CDD:214500
		GAF	254..441	CDD:214500	9/39 (23%)
		PDEase_I	558..802	CDD:278654	68/248 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820