DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pde9 and Pde6a

DIOPT Version :10

Sequence 1:NP_727644.3 Gene:Pde9 / 32233 FlyBaseID:FBgn0259171 Length:1623 Species:Drosophila melanogaster
Sequence 2:NP_001100856.1 Gene:Pde6a / 307401 RGDID:1306835 Length:860 Species:Rattus norvegicus


Alignment Length:468 Identity:118/468 - (25%)
Similarity:198/468 - (42%) Gaps:94/468 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   619 DDDFRALVKDLKRKVEYTERMNWLCLSKRPLGPPHRKSSLPKHQEVKRRFLEI------CDTTFS 677
            ||....|::.|      |:.:.|..|:      |....|:.|.:..|..|.:|      ||   :
  Rat   413 DDMDETLMESL------TQFLGWSVLN------PDTYESMNKLENRKDIFQDIVKYHVKCD---N 462

  Fly   678 EEVRAALR------------------------LPAFDSYE-----WSDADVIHLMQT-----MFV 708
            ||::..|:                        ||..:.||     :||..:..|...     |:.
  Rat   463 EEIQKILKTREVYGKEPWECEEEELAEILQEELPDAEKYEINKFHFSDLPLTELELVKCGIQMYY 527

  Fly   709 ELGFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLIL 773
            ||..::||.||.:.|..::|.:.|.|..:.:||:||.|.|.|.|:::.....|.....|||.|.:
  Rat   528 ELRVVDKFHIPQEALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLMTGKLKRYFTDLEALAM 592

  Fly   774 LVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFN 838
            :.:..|||:||.|.||:||:.::..|| :.:..|.||.||......||.....|||:|.:|....
  Rat   593 VTAAFCHDIDHRGTNNLYQMKSQNPLA-KLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHE 656

  Fly   839 NIREGIIRCILATDMARHNEILTQFMEITPIFDYS---------------NRAHINLLCMILIKV 888
            :....:...|:|||:|.:.:..|.|.:|.   |.|               .:....::..:::..
  Rat   657 HAIHMMDIAIIATDLALYFKKRTMFQKIV---DQSKTYESTQEWTQYMMLEQTRKEIVMAMMMTA 718

  Fly   889 ADISNEARPMDVAEPWLDRLLQEFFAQSAAEKS--EGLPVTPFMDPDKVSK-PGSQVRFIGLVLL 950
            .|:|...:|.:|.......:..||:.|...|::  :..|: |.||.:|..: |..||.||..|..
  Rat   719 CDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPI-PMMDRNKADELPKLQVGFIDFVCT 782

  Fly   951 PLFEALGELVPELTELI--IIPVR-----IALEYYRRLNDAQTKTRKSVADSNTSATSDSNSGTI 1008
            .:::.......|:|.::  |...|     :|.||..|:...:.:.:|..| :..:|:.:...|. 
  Rat   783 FVYKEFSRFHEEITPMLDGITNNRKEWKALADEYEARMKALEEEKQKQQA-AKQAASGNQPGGN- 845

  Fly  1009 DSNAAMVSTPGGA 1021
                   .:||||
  Rat   846 -------PSPGGA 851

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde9NP_727644.3 PDEase_I 739..967 CDD:459723 68/245 (28%)
Pde6aNP_001100856.1 GAF 80..232 CDD:214500
GAF 254..441 CDD:214500 9/39 (23%)
PDEase_I 558..802 CDD:459723 68/248 (27%)
Blue background indicates that the domain is not in the aligned region.

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