DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and Pde3b

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	NP_058925.2	Gene:	Pde3b / 29516	RGDID:	61943	Length:	1111	Species:	Rattus norvegicus

Alignment Length:	795	Identity:	178/795 - (22%)
Similarity:	285/795 - (35%)	Gaps:	213/795 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 PPPAIAVTTTTTATV---RRKSSSSSTISGTATVSGSVSVSASASQSFCSNNINLLEELLIQFYE 381
            |||..|.|......|   ||:||..|.....|...||..:....|....|.     |::::..::
  Rat   258 PPPRSASTADEKVPVIRPRRRSSCVSLGESAAGYYGSGKMFRRPSLPCISR-----EQMILWDWD 317

  Fly   382 EQDHRSNLTVIRHHHHQQHQQHQQQQRITNNNNNNNNCNSIQNN-NNM--------SNPAATAAA 437
            .:              |..:.|.|     |:...|....|:.|. .||        |.|....::
  Rat   318 LK--------------QWCKPHYQ-----NSGGGNGVDLSVLNEARNMVSDLLIDPSLPPQVISS 363

  Fly   438 --------------------TATP--------SVEQPATSGTTNIHLQPTSLPDGSDNPRRRRAS 474
                                :.||        .||.|...|...:|...:|.| .....:.||:|
  Rat   364 LRSISSLMGAFSGSCRPKINSFTPFPGFYPCSEVEDPVEKGDRKLHKGLSSKP-SFPTAQLRRSS 427

  Fly   475 DCSAVQAALQNQLHC-------------ITLKNNNCGKAMPF------------------HRGSC 508
            ..|.:   |.::.|.             :::.::.|....||                  |....
  Rat   428 GASGL---LTSEHHSRWDRSGGKRPYQELSVSSHGCHLNGPFSSNLMTIPKQRSSSVSLTHHAGL 489

  Fly   509 GAAGEHLLAANSIANRAT-IILSKSC----SNVDGDATATAATALSSTVGGGIGGIGGSIKMRAS 568
            ..||  .|.:.|:.|.:: :.:|..|    |.|....|:...|..|.|:...:|.:       :|
  Rat   490 RRAG--ALPSPSLLNSSSHVPVSAGCLTNRSPVGFLDTSDFLTKPSVTLHRSLGSV-------SS 545

  Fly   569 ATDIETNALNGARDAIVASNNGNN--------GNNGNNGNNEYSILQLNNTIIQCHFNDDDFRAL 625
            |.|......|.  |:.:.|:.|:.        ..:|.:.:||.|             .::|....
  Rat   546 AADFHQYLRNS--DSSLCSSCGHQILKYVSTCEPDGTDHHNEKS-------------GEEDSTVF 595

  Fly   626 VKDLKRKVEYTERMNWLCLSKRPL---GPPH--RKSSLPK-HQEVKRRFLEICDTTFSEEVRAAL 684
            .|:....|| |:....:....|.|   |..|  .::..|. .|||      :.|....|:..:.:
  Rat   596 SKERLNIVE-TQEEETVKEDCRELFLEGDDHLMEEAQQPNIDQEV------LLDPMLVEDYDSLI 653

  Fly   685 RLPA---FDSYEW-------SDADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEVPF 739
            ...:   |..:|.       |...:..:|.|:|.:.|.:|.|.||......:...:...|.::|:
  Rat   654 EKMSNWNFQIFELVEKMGEKSGRILSQVMYTLFQDTGLLETFKIPTQEFMNYFRALENGYRDIPY 718

  Fly   740 HNFRHCFCVAQMMYAITRQ--------------------------------------------AN 760
            ||..|...|...::.:|.:                                            ..
  Rat   719 HNRVHATDVLHAVWYLTTRPIPGLQQLHNNHETETKADSDARLSSGQIAYLSSKSCCIPDKSYGC 783

  Fly   761 LLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRL-LEHP 824
            |.|.:..||.:.|.|:...||.||||..|.:.:......|:.|||.|.|||||.:.|:.| |..|
  Rat   784 LSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRP 848

  Fly   825 ECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQF-MEITPI----FDYSNRAHINLLCMI 884
            |.|...|.....|...|..:|..|||||:.:|.|.|.:| .:...:    .::|:.....|:|.:
  Rat   849 EYNFLLNLDHMEFKRFRFLVIEAILATDLKKHFEFLAEFNAKANDVNSNGIEWSSENDRLLVCQV 913

  Fly   885 LIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVL 949
            .||:|||:..|:..|:...|.:.::.||:.|...|.:.|||::||||.........|..||..::
  Rat   914 CIKLADINGPAKDRDLHLRWTEGIVNEFYEQGDEEATLGLPISPFMDRSSPQLAKLQESFITHIV 978

  Fly   950 LPL---FEALGELVP 961
            .||   ::|.| |:|
  Rat   979 GPLCNSYDAAG-LLP 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	78/276 (28%)
Pde3b	NP_058925.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		Interaction with RAPGEF3. /evidence=ECO:0000250	1..32
		DUF3488	145..>264	CDD:403269	3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..448		9/46 (20%)
		Interaction with PIK3R6. /evidence=ECO:0000250	421..445		6/26 (23%)
		PDEase_I	718..992	CDD:395177	77/274 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010