DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and Pde4c

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	NP_001263694.1	Gene:	Pde4c / 290646	RGDID:	727918	Length:	671	Species:	Rattus norvegicus

Alignment Length:	613	Identity:	159/613 - (25%)
Similarity:	248/613 - (40%)	Gaps:	126/613 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   436 AATATPSVEQPATSGTTNIHLQPTS-------LPDGSDNPRRRRASDCSAVQAALQNQLHCITLK 493
            |.:|.|.|....:.||...|....|       ||.|. .|  ..|...|::..|||..:|....:
  Rat    58 AESAAPVVFTIGSRGTERSHGSAQSSFDLENGLPSGR-GP--LDAQSGSSLGRALQPPVHHGQRR 119

  Fly   494 NNNCGKAMPFHRGSCGAAGEHLLAANSIANRATII-----LSKSCSNVDGDATATAATALSSTVG 553
            .:...::...|..|..|......||:.:.....|:     :..|...|..:..|.|..|.|:|..
  Rat   120 ESFLYRSDSDHEPSPKAVSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQ 184

  Fly   554 GGIGGIGGSIKMRASATDIETNALNGARDAI---------------------VASNNGNN----- 592
            ..:|....|.:..|.|   |.:.|..|::.:                     :|||....
  Rat   185 ALLGTPPQSSQQAAPA---EESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRE 246

  Fly   593 ----GNNGNNGN--NEYSILQLNNTIIQCHFNDDDFRALVKDLKRKVEYTERMNWLCLSKRPLGP 651
                .....:||  :||    ::.|.:              |.:.:||..             .|
  Rat   247 LTHLSETSRSGNQVSEY----ISQTFL--------------DQQAEVELP-------------AP 280

  Fly   652 PHRKSSLPKHQEVKRRFLEICDTTF------------SEEVRAALRLPAFDSYEWSDADVIHLMQ 704
            |......|..|....|  :.|.|:.            .:|.:.|..|.  |:.:|. .||..:.:
  Rat   281 PTEDHPWPMAQITGLR--KSCHTSLPTAAIPRFGVQTDQEEQLAKELE--DTNKWG-FDVFKVAE 340

  Fly   705 ------------TMFVELGFIEKFSIPVDTLREWLYEVYKHY-NEVPFHNFRHCFCVAQMMYAIT 756
                        ::..|...::.|.||.|||..:|..:..|| :.|.:||..|...|.|..:.:.
  Rat   341 LSGNRPLTAVIFSVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLL 405

  Fly   757 RQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLL 821
            ....|.:...|||.|..:.:|..||:||||.:|.:.||..:||||.|||.|.|||||.::.|:||
  Rat   406 GTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLL 470

  Fly   822 EHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQF-----------MEITPIFDYSNR 875
            :...|:||:|.|.....::|..:|..:|||||::|..:|...           :.:..:.:||:|
  Rat   471 QGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDR 535

  Fly   876 AHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGS 940
            ..:   ...|:..||:||.|:|:.:...|.:|::.|||.|...|:..||.::|..|....|...|
  Rat   536 IQV---LQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKS 597

  Fly   941 QVRFIGLVLLPLFEALGELV-PELTELI 967
            ||.||..:..||:|...:|| |:..||:
  Rat   598 QVGFIDYIAHPLWETWADLVHPDAQELL 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	84/239 (35%)
Pde4c	NP_001263694.1	PDEase_I	388..629	CDD:278654	85/241 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347757
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750