Protein Alignment Pde9 and Pde6b

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_001099494.1
• Gene: Pde6b / 289878
• RGDID: 1311039
• Length: 856
• Species: Rattus norvegicus
• Alignment Length: 360
• Identity: 102/360 - (28%)
• Similarity: 167/360 - (46%)
• Gaps: 55/360 - (15%)

  Fly   689 FDSYEWSDADV----IHLMQ---TMFVELGFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCF 746
            ||.||:..:|:    :.|::   .|:.|||.:.||.||.:.|..:|:.|.|.|..:.:||:||.|
  Rat   499 FDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKAYRRITYHNWRHGF 563

  Fly   747 CVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLEN 811
            .|||.|:.:.....|.|...|||...::.:.:|||:||.|.||:||:.::..|| :.:..|.||.
  Rat   564 NVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA-KLHGSSILER 627

  Fly   812 HHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITPIFDYS--- 873
            ||......||.....||::|.:|....::...:...|:|||:|.:.:..|.|.:|.   |.|
  Rat   628 HHLEFGKFLLAEESLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIV---DESKNY 689

  Fly   874 --NRAHINLLCM----------ILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKS--EGL 924
              .::.:..|.:          :::...|:|...:|.:|.......:..||:.|...|::  :..
  Rat   690 EDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQ 754

  Fly   925 PVTPFMDPDKVSK-PGSQVRFIGLV--------------LLPLFEALGELVPELTELIIIPVRIA 974
            |: |.||.:|.:: |..||.||..|              :||:|:.|.....|...|       |
  Rat   755 PI-PMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL-------A 811

  Fly   975 LEY---YRRLNDAQTKTRKSVADSNTSATSDSNSG 1006
            .||   .:.|.:.:.|....|| :..:.|...|.|
  Rat   812 DEYEAKVKALEEEKKKEEDRVA-AKKAGTEICNGG 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	72/259 (28%)
Pde6b	NP_001099494.1	GAF	71..230	CDD:214500
		GAF	252..439	CDD:214500
		PDEase_I	556..800	CDD:459723	70/248 (28%)