Protein Alignment Pde9 and PDE7B

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_061818.1
• Gene: PDE7B / 27115
• HGNCID: 8792
• Length: 450
• Species: Homo sapiens
• Alignment Length: 366
• Identity: 93/366 - (25%)
• Similarity: 153/366 - (41%)
• Gaps: 71/366 - (19%)

  Fly   699 VIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHY-NEVPFHNFRHCFCVAQMMYAITRQANLL 762
            ::.|:..:|...|.|..|.:.:.||..:|..|.:.| ::.|:||..|...|.|.|:...::..|.
Human   131 LVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLA 195

  Fly   763 SRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECN 827
            |.|..|:.::.|::...||:||||.|..:.|.....||..|.::|.|||||......:|.  |..
Human   196 SFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLR--ESR 258

  Fly   828 IFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITPIFDYSNRAHI-------------N 879
            :..:..::...:|.:.:...|||||:.|.||.||:.           :||:             :
Human   259 LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRL-----------KAHLHNKDLRLEDAQDRH 312

  Fly   880 LLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRF 944
            .:..|.:|.|||.|..|..::::.|.:|:.:||:.|...|:...|.::|..:..|.|.|..|:.|
Human   313 FMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGF 377

  Fly   945 IGLVLLPLFEALGELVPELTELIIIPVRIALEYYRRLNDAQTKTRKSVADSNTSATSDSNSGTID 1009
            :..::.|||                                   |:....:..|..|::..|.:.
Human   378 MSYIVEPLF-----------------------------------REWAHFTGNSTLSENMLGHLA 407

  Fly  1010 SNAAMVSTPGGASDKLSLDKGQGNSQGSGGGGGGGGGGGAG 1050
            .|.|...         ||...|..|:||.|.|......|.|
Human   408 HNKAQWK---------SLLPRQHRSRGSSGSGPDHDHAGQG 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	66/240 (28%)
PDE7B	NP_061818.1	PDEase_I	172..392	CDD:278654	67/267 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	418..450		8/22 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820