DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and Pde4a

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	NP_037233.4	Gene:	Pde4a / 25638	RGDID:	3279	Length:	844	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	138/554 - (24%)
Similarity:	222/554 - (40%)	Gaps:	144/554 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   702 LMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYN-EVPFHNFRHCFCVAQMMYAITRQANLLSRL 765
            :|.|:|.|...::||.|||||:..::..:..||: :|.:||..|...|.|..:.:.....|.:..
  Rat   380 IMYTIFQERDLLKKFHIPVDTMMMYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVF 444

  Fly   766 GDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFK 830
            .|||.|..|.:...||:||||.:|.:.||..:||||.|||.|.|||||.::.|:||:...|:||:
  Rat   445 TDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEENCDIFQ 509

  Fly   831 NFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITP-----------IFDYSNRAHINLLCMI 884
            |.|:....::|:.:|..:|||||::|..:|.....:..           :.:||:|..:   ...
  Rat   510 NLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQV---LRN 571

  Fly   885 LIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVL 949
            ::..||:||..:|:::...|.||::.|||.|...|:..|:.::|..|....|...|||.||..::
  Rat   572 MVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIV 636

  Fly   950 LPLFEALGELV-PELTELIIIPVRIALEYYRRLNDAQTKTRKSVADSNTSATSDSNSGTIDSNAA 1013
            .||:|...:|| |:..:::                   .|.:...|...||...|.|..::..
  Rat   637 HPLWETWADLVHPDAQDIL-------------------DTLEDNRDWYHSAIRQSPSPPLEEE-- 680

  Fly  1014 MVSTPGGASDKLSLDKGQGNSQGSGGGGGGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISV 1078
                |||..                                           .|.:|.
  Rat   681 ----PGGLG-------------------------------------------HPSLPD------- 691

  Fly  1079 KSRRSIPSQKSASRTSVDEPGGMASELHDLPEGSES------------------GDSETATEVDV 1125
            |.:..:..::.....|::.||        ||...|:                  |.|.|.  |:|
  Rat   692 KFQFELTLEEEEEEDSLEVPG--------LPTTEETFLAAEDARAQAVDWSKVKGPSTTV--VEV 746

  Fly  1126 AEKTSKFKVDTEGSSNRSKSSHSTS------------RKSSREKRPSMIGELCSSGGGQRIRNSY 1178
            ||:..:......|:...|..:...|            ..||.|:.|.::| |.|:..
  Rat   747 AERLKQETASAYGAPQESMEAVGCSFSPGTPILPDVRTLSSSEEAPGLLG-LPSTAA-------- 802

  Fly  1179 GNIHGYHSNRCHFGNNRAVSLDQYSSAGNNRRLS 1212
                ...:.|.|....||.|....:|..|:..:|
  Rat   803 ----EVEAPRDHLAATRACSACSGTSGDNSAIIS 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	81/239 (34%)
Pde4a	NP_037233.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..124
		PDE4_UCR	173..288	CDD:407935
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..317
		PDEase_I	418..659	CDD:395177	82/262 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..690		7/70 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..844		4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820