Protein Alignment Pde9 and Pde4d

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_001106799.1
• Gene: Pde4d / 24627
• RGDID: 3281
• Length: 803
• Species: Rattus norvegicus
• Alignment Length: 781
• Identity: 178/781 - (22%)
• Similarity: 286/781 - (36%)
• Gaps: 206/781 - (26%)

  Fly   393 RHHHHQQHQQHQQQQRITNNNNNNNNCNSIQNNNNMSNPAATAAATATPSVEQPATSGTTNIHLQ 457
            ||..|.|:...|.|.|:            :..::::..|        .|...||        .||
  Rat    34 RHEQHHQYPLRQPQFRL------------LHPHHHLPPP--------PPPSPQP--------QLQ 70

  Fly   458 PTSLP------------------DGSDNPRRRRASD------CSAVQ------------------ 480
            |...|                  .|:...|.|..||      |.|:.
  Rat    71 PPPPPPLPPPPPPPGATRGRYASSGASRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSR 135

  Fly   481 ----AALQNQLHCITLKNNNCGKAMPFHRGSCGAAGEHLLAANSI-ANRATIILSKSCSNVDGDA 540
                ::.|. |....:.|.......|....:...:| .:|.||.: :.|....|.:|.|:.|
  Rat   136 MSWPSSFQG-LRRFDVDNGTSAGRSPLDPMTSPGSG-LILQANFVHSQRRESFLYRSDSDYD--- 195

  Fly   541 TATAATALSSTVGGGIGG----IGGSIKMRASATDIETN--ALNGARDAIVASN----NGNNGNN 595
            .:..:.:.:|::...|.|    :....::.||...:..|  ||...:|...:..    |..:.|.
  Rat   196 LSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINK 260

  Fly   596 GNNGNNEY------------------SILQLNNTIIQCHFNDDDFRALVKDLKRKVEYTERMNWL 642
            .......|                  ..||..:::.:...|... |.|.::|....|.:...|.:
  Rat   261 ATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFK-RMLNRELTHLSEMSRSGNQV 324

  Fly   643 C--LSKRPLGPPHR---KSSLPKHQEVKRR----------------FLEICDTTF--SEEVRAAL 684
            .  :|...|...|.   .|...|.:|.|:|                ....|...|  ..|....|
  Rat   325 SEYISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSCIPRFGVKTEQEDVL 389

  Fly   685 RLPAFDSYEWSDADVIH---------------LMQTMFVELGFIEKFSIPVDTLREWLYEVYKHY 734
            .....|..:|.    :|               :|.|:|.|...::.|.||||||..:|..:..||
  Rat   390 AKELEDVNKWG----LHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHY 450

  Fly   735 N-EVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTE 798
            : :|.:||..|...|.|..:.:.....|.:...|||.|..:.:...||:||||.:|.:.||..:|
  Rat   451 HADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSE 515

  Fly   799 LALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQF 863
            |||.|||.|.|||||.::.|:||:...|:||:|.::....::|:..|..:|||||::|..:|...
  Rat   516 LALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMAIDIVLATDMSKHMNLLADL 580

  Fly   864 MEITP-----------IFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSA 917
            ..:..           :.:||:|..:   ...::..||:||..:|:.:...|.||:::|||.|..
  Rat   581 KTMVETKKVTSSGVLLLDNYSDRIQV---LQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGD 642

  Fly   918 AEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEYYRRL- 981
            .|:..|:.::|..|....|...|||.||..::.||:|...:||....:.|:..:....|:|:..
  Rat   643 RERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTI 707

  Fly   982 -----------------------------NDAQTKTRK----------SVADSNTSATSDSNSGT 1007
                                         .|.::.|.|          |.:||.|..|.||.|..
  Rat   708 PQSPSPAPDDQEDGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTE 772

  Fly  1008 I 1008
            |
  Rat   773 I 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	78/238 (33%)
Pde4d	NP_001106799.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103		17/96 (18%)
		PDE4_UCR	218..334	CDD:465648	18/116 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..358		5/19 (26%)
		PDEase_I	456..696	CDD:459723	79/242 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	705..724		0/18 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..803		12/42 (29%)