Protein Alignment Pde9 and Pde11a

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_006499516.1
• Gene: Pde11a / 241489
• MGIID: 3036251
• Length: 1011
• Species: Mus musculus
• Alignment Length: 796
• Identity: 175/796 - (21%)
• Similarity: 302/796 - (37%)
• Gaps: 200/796 - (25%)

  Fly   419 CNSIQNNNNMSNPAATAAATATPSVEQPATSGTTNIHLQPTSLPDGSDNPRRRRASDCSAVQAAL 483
            |:|.:|:|.:..|......            |....|.:..::||...:  ||...:...:....
Mouse   269 CSSTENSNEVQVPWGKGII------------GYVGEHGETVNIPDAYQD--RRFNDEIDKLTGYK 319

  Fly   484 QNQLHCITLKN------------NNCGKAMPFHRGS----------CGAA--GEHLLAAN----- 519
            ...|.|:.::|            |...:..||....          ||.|  ...|.||:
Mouse   320 TKSLLCMPIRNSDGEIIGVAQAINKVPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYE 384

  Fly   520 ------------------------SIANRATIIL--------------------SKSCSNVDGDA 540
                                    .|.:||..:|                    :||...:....
Mouse   385 RSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKC 449

  Fly   541 TATAATALSSTVGGGIGG---IGGSIKMRASATDIETNALNGARD-AIVASNNGNNGNN------ 595
            :|.|..:...:|......   |..||....::|.:..|..:..:| ...|..:..:|.:
Mouse   450 SADAENSFKESVEKSSYSDWLINNSIAELVASTGLPVNVSDAYQDPRFDAEADQISGFHIRSVLC 514

  Fly   596 ---GNNGNNEYSILQLNNTIIQCHFNDDD---FRALV----KDLKRKVEYTE-RMNWLCLSKRPL 649
               .|:.:....:.|:.|.:....|:|.|   |.|.|    ..:...:.|.: :.:|   :|:.:
Mouse   515 VPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSW---AKQSV 576

  Fly   650 G----PPHRKSSLPKHQEVKRRFLEICDTTFSEEVRAALRLPAFDSYEWSDADVIHLMQTMFVEL 710
            .    ..|...|..:..:.|...:.:......:::.       ||.:......:|.....||:||
Mouse   577 ALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIH-------FDDFSLDVDAMITAALRMFMEL 634

  Fly   711 GFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLV 775
            |.::||.|..:||..||..|.|:|..|.:||:||.|.|.|:|:|:...|.....|.::|.|.::|
Mouse   635 GMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQEILTEVEILAVIV 699

  Fly   776 SCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNI 840
            .|:||||||.|.||.:|..:.:.||..|...:.||:||.:.|..:|:....|||.|.|...::::
Mouse   700 GCLCHDLDHRGTNNAFQAKSDSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDL 764

  Fly   841 REGIIRCILATDMARHNEILTQFMEIT--PIFDYSNRAHINLLCMILIKVADISNEARPMDVAEP 903
            .:.:.:.|||||:..:.|..|:|.|:.  ..:|:|..:|.::...:|:...|:....:|.:::..
Mouse   765 MQLLKQSILATDLTLYFERRTEFFELVRKGDYDWSITSHRDVFRSMLMTACDLGAVTKPWEISRQ 829

  Fly   904 WLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSK---PGSQVRFIGLVLLPLFEALG------EL 959
            ..:.:..|||.|...|:|| |.:||....|:..|   |..|:.:|..:.:||::::|      |.
Mouse   830 VAELVTSEFFEQGDRERSE-LKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQSIGSNIRGPEF 893

  Fly   960 VPELTELIIIPVRIALEYYRRLNDAQTKTRKSVADSNTSATSDSNSGTIDSNAAMVSTPGGASDK 1024
            :.|.||         |.::..||::.|                              |.|...|.
Mouse   894 LTESTE---------LAFFVYLNESLT------------------------------TGGWEGDS 919

  Fly  1025 L-----SLDKGQGNSQGSGGGGGGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISVKSRRSI 1084
            |     .|.:||..::.:.|              .|||.....|.|:   |:..:|:....|
Mouse   920 LLLFFAGLGEGQCKTETNAG--------------FSGCQPKEVGRVA---PKKTTGLGCLPR--- 964

  Fly  1085 PSQK--SASRTSVDEP 1098
            |.|.  ...|.:|:.|
Mouse   965 PCQSHGGRGRQTVNHP 980

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	76/238 (32%)
Pde11a	XP_006499516.1	GAF	217..380	CDD:214500	23/124 (19%)
		GAF	402..568	CDD:214500	27/165 (16%)
		PDEase_I	663..900	CDD:459723	76/246 (31%)