Protein Alignment Pde9 and Pde8b

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_001360932.1
• Gene: Pde8b / 218461
• MGIID: 2443999
• Length: 885
• Species: Mus musculus
• Alignment Length: 919
• Identity: 196/919 - (21%)
• Similarity: 326/919 - (35%)
• Gaps: 273/919 - (29%)

  Fly   296 DTEDNEEEQEHPSEKPE--------RTDIEEEPPPAIAVTTTTTATVRRK-----SSSSSTISGT 347
            |..::..:....|:.|.        :||..:..||:.|........|||.     |.||:..||.
Mouse    21 DESNSPRQTSSVSQGPTAPLHGLFVQTDAADAMPPSRAAGPPGAVRVRRSRAELGSGSSTGSSGP 85

  Fly   348 ATVS-------GSVSVSASASQSFCS-NNINLLE-------------ELLIQFYEEQD------- 384
            ||.:       ...|..|....|:.| ..::..|             ::|:.|.:|..
Mouse    86 ATTTCRGRRRHCCSSAEAETQTSYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWW 150

  Fly   385 ------HRSNLT---------VIRHHHHQQHQQHQQQQRITNNNNNNNNCNSIQNNNNMSNPAAT 434
                  :|.|:.         .:..||......|:|    :.|.:....|.||:..|...:....
Mouse   151 ACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQ----SRNFDAEAVCRSIRATNPSEHTVIL 211

  Fly   435 AAATATPSVEQPAT------SGTTNIHLQPTSL---------PDGSDNPRRRRASDCSAVQAALQ 484
            |..:......:.|:      :|.....::.:|:         .:..:...:.:...|::|..||.
Mouse   212 AVVSQASDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALD 276

  Fly   485 NQLHC------------ITLKNNNCGKAMPFHRGSCGAAGEHLLAANSIANRATIILSKSCSNVD 537
               ||            |...|....:.|.:|:|.        |....:|:     |.||..| .
Mouse   277 ---HCHEAIEITSDDHVIQYVNPAFERMMGYHKGE--------LLGKELAD-----LPKSDKN-R 324

  Fly   538 GDATATAATALSSTVGGGIGGI-------GGSIKMRASATDIETNALNGARDAIVASNNGNNGNN 595
            .|...|..|.:..  |....|:       |.||:.....|.:                      .
Mouse   325 ADLLDTINTCIKK--GKEWQGVYYARRKSGDSIQQHVKITPV----------------------I 365

  Fly   596 GNNGNNEY--SILQL------NNTIIQCHFND-DDFRALVKDLKRKVEYTERMNWLCLSKRPLGP 651
            |..|...:  |:.:|      |..|.:.|.:. |:.:......:.|....|.::...:|.|....
Mouse   366 GQGGKIRHFVSLKKLCCTTDSNKQIHRIHRDSGDNSQTEPHSFRHKSRRKESIDVKSISSRGSDA 430

  Fly   652 P----HRKSSLPK-HQ--------------------------EVKRRFLEICDTT---------- 675
            |    .|..|:.: |.                          |...|.|||..||
Mouse   431 PSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTK 495

  Fly   676 ---------------------------FSEEV---RAALRLP------------AFDSYEWSDAD 698
                                       |::.|   .:.|.:|            ..|:.|..|.:
Mouse   496 DEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHHSHSHLSMPITINDVPPSIAQLLDNEESWDFN 560

  Fly   699 V------------IHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEV-PFHNFRHCFCVAQ 750
            :            ::|...:|...|..|..:....|||.||..:..:|:.. .:||..|...|..
Mouse   561 IFELEAVTHKRPLVYLGLKVFSRFGVCEFLNCTETTLRAWLQVIEANYHSSNAYHNSTHAADVLH 625

  Fly   751 MMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCS 815
            .......:..:...|..|:.:..|::...||:||||..|.:..||.:|||:.|||.:.||:||.:
Mouse   626 ATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTA 690

  Fly   816 IAFRL-LEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFM--------------- 864
            :||:| ::..:||||||..|:.:..:|:.||..:|||:|.:|.|.:.:|:
Mouse   691 LAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPLAAESEGSD 755

  Fly   865 -EITPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVT- 927
             |..|.........| |:..::||.||::|..||:|:...|..|:.:|:|||:..||.:||||.
Mouse   756 CECNPTGKNFPENQI-LIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVM 819

  Fly   928 PFMDPDKVSKPGSQVRFIGLVLLPLFEA------LGELVPELTELIIIPVRIALEYYRRLNDAQT 986
            |..|.:..|.|.||:.||...:..:|:|      |..|:..|.:        ..::::.|:|.:.
Mouse   820 PVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLAD--------NYKHWKTLDDLKC 876

  Fly   987 KTRKSVADS 995
            ||.:..:||
Mouse   877 KTLRLPSDS 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	83/251 (33%)
Pde8b	NP_001360932.1	PDE8	1..47	CDD:285793	3/25 (12%)
		PAS	167..375	CDD:225112	41/252 (16%)
		PAS_9	280..377	CDD:379177	22/134 (16%)
		PDEase_I	614..861	CDD:365964	82/247 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950