Protein Alignment Pde9 and Pde2a

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_006507586.1
• Gene: Pde2a / 207728
• MGIID: 2446107
• Length: 953
• Species: Mus musculus
• Alignment Length: 636
• Identity: 146/636 - (22%)
• Similarity: 240/636 - (37%)
• Gaps: 157/636 - (24%)

  Fly   379 FYEEQDHRSNLTVIRHHHHQ---------QHQQHQQ--------------------------QQR 408
            |.:|.:|     ||:|..|.         ..|:.|:                          |:.
Mouse   371 FTDEDEH-----VIQHCFHYTGTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEI 430

  Fly   409 ITNNNNNNNN--CN-SIQNNNNMSNPAATAAATATPSVE--QPATSGTTNIHLQPT----SLPDG 464
            ||...|.:|.  |: .:.:.|.:.............|.|  .||..|... |:..|    ::||.
Mouse   431 ITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAG-HVATTGQILNIPDA 494

  Fly   465 SDNPRRRRASDCSAVQAALQNQLHCITLKNNNCGKAMPFHRGSCGAAGEHLLAANSIANRATIIL 529
            ..:|...|..|.|.  ......:.|..:||.|                :.::....:.|:   |.
Mouse   495 YAHPLFYRGVDDST--GFRTRNILCFPIKNEN----------------QEVIGVAELVNK---IN 538

  Fly   530 SKSCSNVDGDATATAATALSSTVGGGIGGIGGSIKMRASATDIETNALNGARDAIVASNNGNNGN 594
            ....|..|.|    .|||.|...|..|            |..:....:|.|
Mouse   539 GPWFSKFDED----LATAFSIYCGISI------------AHSLLYKKVNEA-------------- 573

  Fly   595 NGNNGNNEYSILQLNNTIIQCHF--NDDDFRALVKDLKRKVEYTERMNWLCLSKRPLGPPHRKSS 657
                   :|. ..|.|.::..|.  :||::..|:.|                ..:|:.
Mouse   574 -------QYR-SHLANEMMMYHMKVSDDEYTKLLHD----------------GIQPVA------- 607

  Fly   658 LPKHQEVKRRFLEICDTTFSEEVRAALRLPAFDSYEWSDADVIHLMQTMFVELGFIEKFSIPVDT 722
                         ..|:.|:........||        :.|....:.:|..::.||..:.|...|
Mouse   608 -------------AIDSNFANFTYTPRSLP--------EDDTSMAILSMLQDMNFINNYKIDCPT 651

  Fly   723 LREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGY 787
            |..:...|.|.|.:.|:||:.|.|.|:...|.:.:...|.:.|.|:|...|.:||:||||||.|.
Mouse   652 LARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELSNYLEDIEIFALFISCMCHDLDHRGT 716

  Fly   788 NNIYQINARTELALRY-NDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILAT 851
            ||.:|:.:::.||..| ::.|.:|.||.:.|..:|....||||.:|||..:..:.:.:...||||
Mouse   717 NNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILAT 781

  Fly   852 DMARHNEILTQFMEITPI-FDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQ 915
            |:|.|..|.....::..: :|.:||.|..||..:|:...|:|::.:.........:.:.:|||:|
Mouse   782 DLAHHLRIFKDLQKMAEVGYDRNNRQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQ 846

  Fly   916 SAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTEL 966
            ...||:.|......||.:|...|..|:.|:..:.:|:::.|.:|.|:..||
Mouse   847 GDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAEL 897

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	75/230 (33%)
Pde2a	XP_006507586.1	GAF	253..400	CDD:214500	8/33 (24%)
		GAF	422..571	CDD:214500	36/186 (19%)
		PDEase_I	668..901	CDD:365964	75/230 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820