Protein Alignment Pde9 and Pde9a

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_612552.1
• Gene: Pde9a / 191569
• RGDID: 621035
• Length: 534
• Species: Rattus norvegicus
• Alignment Length: 394
• Identity: 185/394 - (46%)
• Similarity: 246/394 - (62%)
• Gaps: 24/394 - (6%)

  Fly   628 DLKRKVE----YTERMNWLC----LSKRPLGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRAAL 684
            |:|:..|    ...|.|..|    |..:.|.|.....:.||:             ..|.|...||
  Rat   144 DIKKMREELAARNNRTNCPCKYSFLDNKKLTPRRDVPTYPKY-------------LLSPETIEAL 195

  Fly   685 RLPAFDSYEWSDADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVA 749
            |.|.||.:.|...:::..::.|:.:||.:..|||...|||.||..|:.:|...|||||||||||.
  Rat   196 RKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLCVHDNYRSNPFHNFRHCFCVT 260

  Fly   750 QMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHC 814
            ||||::.....|..:...::.|:|:.:.||||||||||||.||||||||||:|||||||||||||
  Rat   261 QMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHC 325

  Fly   815 SIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITPIFDYSNRAHIN 879
            :|||::|..||||||.:...:.|..||:|:|..|||||||||.||:..|.|....|||||..|:.
  Rat   326 AIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHLT 390

  Fly   880 LLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRF 944
            ||.|||||..|||||.|||:|||||:|.||:|:|.||..||||||||.||||.|||:|..:|:.|
  Rat   391 LLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGF 455

  Fly   945 IGLVLLPLFEALGELVPELTELIIIPVRIALEYY---RRLNDAQTKTRKSVADSNTSATSDSNSG 1006
            |..||:|:||.:.:|.|.:.|.::.|:..:.|:|   ::|:||..:.:|...:..:.||.::...
  Rat   456 IKFVLIPMFETVTKLFPIVEETMLRPLWESREHYEELKQLDDAMKELQKKTENLTSGATENAPEK 520

  Fly  1007 TIDS 1010
            |.|:
  Rat   521 TRDA 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	140/227 (62%)
Pde9a	NP_612552.1	PDEase_I	250..478	CDD:459723	140/227 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..534		5/25 (20%)