DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde9 and Pde9a

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	XP_036016291.1	Gene:	Pde9a / 18585	MGIID:	1277179	Length:	536	Species:	Mus musculus

Alignment Length:	385	Identity:	182/385 - (47%)
Similarity:	242/385 - (62%)	Gaps:	29/385 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   628 DLKRKVE----YTERMNWLC----LSKRPLGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRAAL 684
            |:|:..|    ...|.|..|    |..:.|.|.....:.||:             ..|.|...||
Mouse   144 DIKKMREELAARNSRTNCPCKYSFLDNKKLTPRRDVPTYPKY-------------LLSPETIEAL 195

  Fly   685 RLPAFDSYEWSDADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVA 749
            |.|.||.:.|...:::..::.|:.:||.:..|||...|||.||..|:.:|...|||||||||||.
Mouse   196 RKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLCVHDNYRNNPFHNFRHCFCVT 260

  Fly   750 QMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHC 814
            ||||::.....|..:...::.|:|:.:.||||||||||||.||||||||||:|||||||||||||
Mouse   261 QMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHC 325

  Fly   815 SIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITPIFDYSNRAHIN 879
            :|||::|..||||||.:...:.|..||:|:|..|||||||||.||:..|.|....|||||..|:.
Mouse   326 AIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHLT 390

  Fly   880 LLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRF 944
            ||.|||||..|||||.|||:|||||:|.||:|:|.||..||||||||.||||.|||:|..:|:.|
Mouse   391 LLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGF 455

  Fly   945 IGLVLLPLFEALGELVPELTELIIIPVRIALEYY---RRLNDAQTKTR-----KSVADSN 996
            |..||:|:||.:.:|.|.:.|.::.|:..:.|:|   ::|:||..:.:     ::||:.:
Mouse   456 IKFVLIPMFETVTKLFPVVEETMLRPLWESREHYEELKQLDDAMKEVKAVQRVQAVAEED 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	140/227 (62%)
Pde9a	XP_036016291.1	PDEase_I	250..478	CDD:395177	140/227 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	296	1.000	Domainoid score	I1476
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0004612
OrthoInspector	1	1.000	-	-		oto93281
orthoMCL	1	0.900	-	-		OOG6_103870
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	1	1.000	-	-		X3819
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.750